scholarly journals Synaptic Vesicle Proteins and Active Zone Plasticity

2016 ◽  
Vol 8 ◽  
Author(s):  
Robert J. Kittel ◽  
Manfred Heckmann
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
Vesicle Proteins

Amyloid Precursor Protein Knockout Diminishes Synaptic Vesicle Proteins at the Presynaptic Active Zone in Mouse Brain

2014 ◽  
Vol 11 (10) ◽  
pp. 971-980 ◽  
Author(s):  
Melanie Laßek ◽  
Jens Weingarten ◽  
Amparo Acker-Palmer ◽  
Sandra Bajjalieh ◽  
Ulrike Muller ◽  
...  
Keyword(s):  
Amyloid Precursor Protein ◽  
Synaptic Vesicle ◽  
Mouse Brain ◽  
Active Zone ◽  
Precursor Protein ◽  
Presynaptic Active Zone ◽  
Vesicle Proteins

scholarly journals Presynaptic precursor vesicles originate from the trans-Golgi network, promoted by the small GTPase RAB2

2020 ◽  
Author(s):  
Torsten W. B. Götz ◽  
Dmytro Puchkov ◽  
Janine Lützkendorf ◽  
Alexander G. Nikonenko ◽  
Christine Quentin ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
Molecular Mechanisms ◽  
Small Gtpase ◽  
Neuronal Somata ◽  
Synaptic Terminals ◽  
Vesicle Biogenesis ◽  
Lysosomal Membrane Protein ◽  
Golgi Network ◽  
Vesicle Proteins

SummaryReliable delivery of presynaptic material, including active zone and synaptic vesicle proteins from neuronal somata to synaptic terminals is prerequisite for faithful synaptogenesis and neurotransmission. However, molecular mechanisms controlling the somatic assembly of presynaptic precursors remain insufficiently understood. Here we show that in mutants of the small GTPase RAB2 active zone and synaptic vesicle proteins accumulated in the neuronal somata at the trans-Golgi network and were consequently depleted at synaptic terminals, provoking neurotransmission deficits. The ectopic presynaptic material accumulations consisted of heterogeneous vesicles and short tubules of 40×60 nm and segregated in subfractions either positive for active zone proteins or co-positive for synaptic vesicle proteins and LAMP1, a lysosomal membrane protein. Genetically, rab2 behaved epistatic over arl8, a lysosomal adaptor controlling axonal export of precursors. Collectively, we here identified a Golgi-associated assembly sequence in presynaptic precursor vesicle biogenesis controlled by RAB2 dependent membrane remodelling and protein sorting at the trans-Golgi.

scholarly journals Rab2 regulates presynaptic precursor vesicle biogenesis at the trans-Golgi

2021 ◽  
Vol 220 (5) ◽  
Author(s):  
Torsten W.B. Götz ◽  
Dmytro Puchkov ◽  
Veronika Lysiuk ◽  
Janine Lützkendorf ◽  
Alexander G. Nikonenko ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
Molecular Mechanisms ◽  
Neuronal Cell ◽  
Small Gtpase ◽  
Neuronal Cell Body ◽  
Synaptic Terminals ◽  
Vesicle Biogenesis ◽  
Lysosomal Membrane Protein ◽  
Vesicle Proteins

Reliable delivery of presynaptic material, including active zone and synaptic vesicle proteins from neuronal somata to synaptic terminals, is prerequisite for successful synaptogenesis and neurotransmission. However, molecular mechanisms controlling the somatic assembly of presynaptic precursors remain insufficiently understood. We show here that in mutants of the small GTPase Rab2, both active zone and synaptic vesicle proteins accumulated in the neuronal cell body at the trans-Golgi and were, consequently, depleted at synaptic terminals, provoking neurotransmission deficits. Ectopic presynaptic material accumulations consisted of heterogeneous vesicles and short tubules of 40 × 60 nm, segregating in subfractions either positive for active zone or synaptic vesicle proteins and LAMP1, a lysosomal membrane protein. Genetically, Rab2 acts upstream of Arl8, a lysosomal adaptor controlling axonal export of precursors. Collectively, we identified a Golgi-associated assembly sequence of presynaptic precursor biogenesis dependent on a Rab2-regulated protein export and sorting step at the trans-Golgi.

scholarly journals Coordinated bi-directional trafficking of synaptic vesicle and active zone proteins in peripheral nerves

2021 ◽  
Vol 559 ◽  
pp. 92-98
Author(s):  
Judyta K. Juranek ◽  
Konark Mukherjee ◽  
Reinhard Jahn ◽  
Jia-Yi Li
Keyword(s):  
Synaptic Vesicle ◽  
Peripheral Nerves ◽  
Active Zone

scholarly journals The DISABLED protein functions in CLATHRIN-mediated synaptic vesicle endocytosis and exoendocytic coupling at the active zone

2011 ◽  
Vol 108 (25) ◽  
pp. E222-E229 ◽  
Author(s):  
F. Kawasaki ◽  
J. Iyer ◽  
L. L. Posey ◽  
C. E. Sun ◽  
S. E. Mammen ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Active Zone ◽  
The Disabled ◽  
Protein Functions
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