scholarly journals Large-Scale Analysis of Gene Expression and Connectivity in the Rodent Brain: Insights through Data Integration

2011 ◽  
Vol 5 ◽  
Author(s):  
Leon French ◽  
Powell Patrick Cheng Tan ◽  
Paul Pavlidis
Keyword(s):  
Gene Expression ◽  
Data Integration ◽  
Large Scale ◽  
Scale Analysis ◽  
Rodent Brain ◽  
Large Scale Analysis

Sex differences in viral entry protein expression and host transcript responses to SARS-CoV-2

2020 ◽  
Author(s):  
Mengying Sun ◽  
Rama Shankar ◽  
Meehyun Ko ◽  
Christopher Daniel Chang ◽  
Shan-Ju Yeh ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sex Differences ◽  
Viral Entry ◽  
Large Scale ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Scale Analysis ◽  
Transcriptional Responses ◽  
Deconvolution Analysis ◽  
Large Scale Analysis

Abstract Epidemiological studies suggest that men exhibit a higher mortality rate to COVID-19 than women, yet the underlying biology is largely unknown. Here, we seek to delineate sex differences in the gene expression of viral entry proteins ACE2 and TMPRSS2, and host transcriptional responses to SARS-CoV-2 through large-scale analysis of genomic and clinical data. We first compiled 220,000 human gene expression profiles from three databases and completed the meta-information through machine learning and manual annotation. Large scale analysis of these profiles indicated that male samples show higher expression levels of ACE2 and TMPRSS2 than female samples, especially in the older group (>60 years) and in the kidney. Subsequent analysis of 6,031 COVID-19 patients at Mount Sinai Health System revealed that men have significantly higher creatinine levels, an indicator of impaired kidney function. Further analysis of 782 COVID-19 patient gene expression profiles taken from upper airway and blood suggested men and women present distinct expression changes. Computational deconvolution analysis of these profiles revealed male COVID-19 patients have enriched kidney-specific mesangial cells in blood compared to healthy patients. Together, this study suggests biological differences in the kidney between sexes may contribute to sex disparity in COVID-19.

scholarly journals Large-Scale Analysis of Putative Soybean Regulatory Gene Expression Identifies a Myb Gene Involved in Soybean Nodule Development

2009 ◽  
Vol 151 (3) ◽  
pp. 1207-1220 ◽  
Author(s):  
Marc Libault ◽  
Trupti Joshi ◽  
Kaori Takahashi ◽  
Andrea Hurley-Sommer ◽  
Kari Puricelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Large Scale ◽  
Regulatory Gene ◽  
Nodule Development ◽  
Scale Analysis ◽  
Myb Gene ◽  
Large Scale Analysis ◽  
Soybean Nodule

A new tool for rheumatology: large-scale analysis of gene expression

2003 ◽  
Vol 70 (4) ◽  
pp. 248-256 ◽  
Author(s):  
Thierry Lequerré ◽  
Cédric Coulouarn ◽  
Céline Derambure ◽  
Grégory Lefebvre ◽  
Olivier Vittecoq ◽  
...  
Keyword(s):  
Gene Expression ◽  
Large Scale ◽  
Scale Analysis ◽  
Large Scale Analysis

Use of Spotted Oligonucleotide Arrays for Large-Scale Analysis of Mammalian Gene Expression

CHEST Journal ◽  
2002 ◽  
Vol 121 (3) ◽  
pp. 80S ◽  
Author(s):  
David J. Erle ◽  
Laura Koth ◽  
Oren Abramson ◽  
Madeleine W. Rodriguez ◽  
Andrea Barczak
Keyword(s):  
Gene Expression ◽  
Large Scale ◽  
Scale Analysis ◽  
Oligonucleotide Arrays ◽  
Mammalian Gene ◽  
Large Scale Analysis ◽  
Mammalian Gene Expression
Sign in / Sign up

Export Citation Format

Share Document