scholarly journals Alterations of Resting-State Static and Dynamic Functional Connectivity of the Dorsolateral Prefrontal Cortex in Subjects with Internet Gaming Disorder

2018 ◽  
Vol 12 ◽  
Author(s):  
Xu Han ◽  
Xiaowei Wu ◽  
Yao Wang ◽  
Yawen Sun ◽  
Weina Ding ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Dorsolateral Prefrontal Cortex ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Dynamic Functional Connectivity ◽  
Internet Gaming ◽  
Dorsolateral Prefrontal

scholarly journals Differences in resting-state functional connectivity according to the level of impulsiveness in patients with internet gaming disorder

2021 ◽  
Vol 10 (1) ◽  
pp. 88-98
Author(s):  
Soo-Jeong Kim ◽  
Min-Kyeong Kim ◽  
Yu-Bin Shin ◽  
Hesun Erin Kim ◽  
Jun Hee Kwon ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
Inferior Frontal Gyrus ◽  
Internet Gaming Disorder ◽  
Healthy Controls ◽  
Gaming Disorder ◽  
Resting State Functional Connectivity ◽  
Brain Functions ◽  
Internet Gaming

AbstractBackground and aimsImpulsiveness is an important factor in the pathophysiology of Internet gaming disorder (IGD), and regional brain functions can be different depending on the level of impulsiveness. This study aimed to demonstrate that different brain mechanisms are involved depending on the level of impulsiveness among patients with IGD.MethodsResting-state functional MRI data were obtained from 23 IGD patients with high impulsivity, 27 IGD patients with low impulsivity, and 22 healthy controls, and seed-based functional connectivity was compared among the three groups. The seed regions were the ventromedial prefrontal cortex (vmPFC), dorsolateral prefrontal cortex, nucleus accumbens (NAcc), and amygdala.ResultsConnectivity of the vmPFC with the left temporo-parietal junction (TPJ) and NAcc-left insula connectivity were significantly decreased in the patients with high impulsivity, compared with the patients with low impulsivity and healthy controls. On the other hand, amygdala-based connectivity with the left inferior frontal gyrus showed decreases in both patient groups, compared with the healthy controls.ConclusionThese findings may suggest a potential relationship between impulsivity and deficits in reward-related social cognition processes in patients with IGD. In particular, certain interventions targeted at vmPFC-TPJ connectivity, found to be impulsivity-specific brain connectivity, are likely to help with addiction recovery among impulsive patients with IGD.

scholarly journals Mechanisms of transcranial magnetic stimulation in the treatment of anorexia nervosa

BJPsych Open ◽  
2021 ◽  
Vol 7 (S1) ◽  
pp. S49-S50
Author(s):  
Lydia Shackshaft
Keyword(s):  
Anorexia Nervosa ◽  
Prefrontal Cortex ◽  
Functional Connectivity ◽  
Resting State ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Resting State Functional Connectivity ◽  
Dorsolateral Prefrontal ◽  
Neurophysiological Mechanisms

AimsSevere and Enduring Anorexia Nervosa (SE-AN) is a challenging condition to treat, with limited therapeutic options, high morbidity, and the highest mortality rates of any psychiatric illness. Repetitive Transcranial Magnetic Stimulation (rTMS) is an emerging treatment option, as evidence demonstrates promising efficacy in improving mood and reducing core Anorexia Nervosa symptoms, as well as safety and tolerability to patients. We aimed to investigate the neurophysiological mechanisms of rTMS use in SE-AN patients by assessing changes in resting state functional connectivity, in the first functional neuroimaging analysis investigating rTMS effects in Anorexia Nervosa patients.Method26 females with a current diagnosis of SE-AN received 20 sessions of sham or real high frequency rTMS (10 hertz) to the left dorsolateral prefrontal cortex in a randomised double-blind trial. Resting-state functional magnetic resonance imaging was performed before and after rTMS. Neural correlates of rTMS treatment were identified using a seed-based functional connectivity analysis with the left dorsolateral prefrontal cortex and bilateral amygdalae as regions of interest. Functional connectivity differences were analysed using t-contrasts in a mixed ANOVA (flexible factorial analysis) to assess interactions between treatment group (real rTMS vs sham) and time-point (pre or post TMS).ResultNo statistically significant changes in resting-state functional connectivity were observed post-rTMS compared to baseline in participants receiving active rTMS compared to sham. Increased functional connectivity between the left amygdala and left pre-supplementary motor area was observed to reach cluster-wise significance (PFWE < 0.05). However, after Bonferroni correction for multiple comparisons (3 seed regions), this did not reach the significance threshold PFWE <0.017.ConclusionThis study highlights the need for further investigation of neurophysiological mechanisms, including resting-state functional connectivity modulation, resulting from rTMS to the dorsolateral prefrontal cortex in SE-AN patients. This requires higher powered studies to account for heterogeneity in treatment response. We have provided some indication that high frequency rTMS may have therapeutic benefit in SE-AN by modification of functional connectivity between prefrontal and limbic brain regions, resulting in improved top-down cognitive control over emotional processing and ability to enact goal-directed behaviours, enabling secondary reductions in eating disorder behaviours.

scholarly journals Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder

2015 ◽  
Vol 21 (3) ◽  
pp. 743-751 ◽  
Author(s):  
Jin-Tao Zhang ◽  
Yuan-Wei Yao ◽  
Chiang-Shan R. Li ◽  
Yu-Feng Zang ◽  
Zi-Jiao Shen ◽  
...  
Keyword(s):  
Young Adults ◽  
Functional Connectivity ◽  
Resting State ◽  
Internet Gaming Disorder ◽  
Gaming Disorder ◽  
Resting State Functional Connectivity ◽  
Internet Gaming
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