scholarly journals Changes in Motor-Related Cortical Activity Following Deep Brain Stimulation for Parkinson’s Disease Detected by Functional Near Infrared Spectroscopy: A Pilot Study

2016 ◽  
Vol 10 ◽  
Author(s):  
Takashi Morishita ◽  
Masa-aki Higuchi ◽  
Kazuya Saita ◽  
Yoshio Tsuboi ◽  
Hiroshi Abe ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Infrared Spectroscopy ◽  
Deep Brain Stimulation ◽  
Pilot Study ◽  
Near Infrared Spectroscopy ◽  
Brain Stimulation ◽  
Near Infrared ◽  
Cortical Activity ◽  
Functional Near Infrared Spectroscopy ◽  
Deep Brain

scholarly journals Cortical hemodynamic mapping of subthalamic nucleus deep brain stimulation in Parkinsonian patients, using high-density functional near-infrared spectroscopy

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245188
Author(s):  
Mahdi Mahmoudzadeh ◽  
Fabrice Wallois ◽  
Mélissa Tir ◽  
Pierre Krystkowiak ◽  
Michel Lefranc
Keyword(s):  
Infrared Spectroscopy ◽  
Deep Brain Stimulation ◽  
Near Infrared Spectroscopy ◽  
Brain Stimulation ◽  
Near Infrared ◽  
Hand Movement ◽  
Functional Near Infrared Spectroscopy ◽  
Dorsolateral Prefrontal ◽  
Stn Dbs ◽  
Deep Brain

Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for idiopathic Parkinson’s disease. Despite recent progress, the mechanisms responsible for the technique’s effectiveness have yet to be fully elucidated. The purpose of the present study was to gain new insights into the interactions between STN-DBS and cortical network activity. We therefore combined high-resolution functional near-infrared spectroscopy with low-resolution electroencephalography in seven Parkinsonian patients on STN-DBS, and measured cortical haemodynamic changes at rest and during hand movement in the presence and absence of stimulation (the ON-stim and OFF-stim conditions, respectively) in the off-drug condition. The relative changes in oxyhaemoglobin [HbO], deoxyhaemoglobin [HbR], and total haemoglobin [HbT] levels were analyzed continuously. At rest, the [HbO], [HbR], and [HbT] over the bilateral sensorimotor (SM), premotor (PM) and dorsolateral prefrontal (DLPF) cortices decreased steadily throughout the duration of stimulation, relative to the OFF-stim condition. During hand movement in the OFF-stim condition, [HbO] increased and [HbR] decreased concomitantly over the contralateral SM cortex (as a result of neurovascular coupling), and [HbO], [HbR], and [HbT] increased concomitantly in the dorsolateral prefrontal cortex (DLPFC)—suggesting an increase in blood volume in this brain area. During hand movement with STN-DBS, the increase in [HbO] was over the contralateral SM and PM cortices was significantly lower than in the OFF-stim condition, as was the decrease in [HbO] and [HbT] in the DLPFC. Our results indicate that STN-DBS is associated with a reduction in blood volume over the SM, PM and DLPF cortices, regardless of whether or not the patient is performing a task. This particular effect on cortical networks might explain not only STN-DBS’s clinical effectiveness but also some of the associated adverse effects.

scholarly journals What Does Sleeping Brain Tell About Stress? A Pilot Functional Near-Infrared Spectroscopy Study Into Stress-Related Cortical Hemodynamic Features During Sleep

2021 ◽  
Vol 3 ◽  
Author(s):  
Zilu Liang
Keyword(s):  
Prefrontal Cortex ◽  
Infrared Spectroscopy ◽  
Pilot Study ◽  
Near Infrared Spectroscopy ◽  
Dorsolateral Prefrontal Cortex ◽  
Near Infrared ◽  
Functional Near Infrared Spectroscopy ◽  
Stress Indicators ◽  
Measured Stress ◽  
Dorsolateral Prefrontal

People with mental stress often experience disturbed sleep, suggesting stress-related abnormalities in brain activity during sleep. However, no study has looked at the physiological oscillations in brain hemodynamics during sleep in relation to stress. In this pilot study, we aimed to explore the relationships between bedtime stress and the hemodynamics in the prefrontal cortex during the first sleep cycle. We tracked the stress biomarkers, salivary cortisol, and secretory immunoglobulin A (sIgA) on a daily basis and utilized the days of lower levels of measured stress as natural controls to the days of higher levels of measured stress. Cortical hemodynamics was measured using a cutting-edge wearable functional near-infrared spectroscopy (fNIRS) system. Time-domain, frequency-domain features as well as nonlinear features were derived from the cleaned hemodynamic signals. We proposed an original ensemble algorithm to generate an average importance score for each feature based on the assessment of six statistical and machine learning techniques. With all channels counted in, the top five most referred feature types are Hurst exponent, mean, the ratio of the major/minor axis standard deviation of the Poincaré plot of the signal, statistical complexity, and crest factor. The left rostral prefrontal cortex (RLPFC) was the most relevant sub-region. Significantly strong correlations were found between the hemodynamic features derived at this sub-region and all three stress indicators. The dorsolateral prefrontal cortex (DLPFC) is also a relevant cortical area. The areas of mid-DLPFC and caudal-DLPFC both demonstrated significant and moderate association to all three stress indicators. No relevance was found in the ventrolateral prefrontal cortex. The preliminary results shed light on the possible role of the RLPCF, especially the left RLPCF, in processing stress during sleep. In addition, our findings echoed the previous stress studies conducted during wake time and provides supplementary evidence on the relevance of the dorsolateral prefrontal cortex in stress responses during sleep. This pilot study serves as a proof-of-concept for a new research paradigm to stress research and identified exciting opportunities for future studies.

Deep brain stimulation in Parkinson's disease: A multicentric, long-term, observational pilot study

2019 ◽  
Vol 405 ◽  
pp. 116411 ◽  
Author(s):  
Emma Scelzo ◽  
Ettore Beghi ◽  
Manuela Rosa ◽  
Serena Angrisano ◽  
Angelo Antonini ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Pilot Study ◽  
Brain Stimulation ◽  
Deep Brain
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