scholarly journals High Frequency Migraine Is Associated with Lower Acute Pain Sensitivity and Abnormal Insula Activity Related to Migraine Pain Intensity, Attack Frequency, and Pain Catastrophizing

Author(s):  
Vani A. Mathur ◽  
Massieh Moayedi ◽  
Michael L. Keaser ◽  
Shariq A. Khan ◽  
Catherine S. Hubbard ◽  
...  
PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262076
Author(s):  
Michal Granot ◽  
Einav Srulovici ◽  
Yelena Granovsky ◽  
David Yarnitsky ◽  
Pora Kuperman

Pain variability can be partially attributed to psycho-cognitive features involved in its processing. However, accumulating research suggests that simple linear correlation between situational and dispositional factors may not be sufficiently explanatory, with some positing a role for mediating influences. In addition, acute pain processing studies generally focus on a post-operative model with less attention provided to post-traumatic injury. As such, this study aimed to investigate a more comprehensive pain processing model that included direct and indirect associations between acute pain intensity in the head and neck, pain catastrophizing (using pain catastrophizing scale (PCS)), and pain sensitivity (using the pain sensitivity questionnaire (PSQ)), among 239 patients with post-motor vehicle collision pain. The effect of personality traits (using Ten Items Personality Inventory (TIPI)) and emotional status (using Hospital Anxiety and Depression Scale (HADS) and Perceived Stress Scale (PSS)) on that model was examined as well. To this end, three Structural Equation Modeling (SEM) analyses were conducted. Overall, the data had good fit to all the models, with only PSQ found to have a direct correlation with acute pain intensity. The SEM analyses conversely revealed several mediations. Specifically, that: first, PSQ fully mediated the relationship between PCS and pain intensity; second, PCS and PSQ together fully mediated the relationship between conscientiousness (personality trait) and pain intensity; and finally, emotional status had direct and indirect links with PSQ and pain intensity. In conclusion, these models suggest that during the acute post-collision phase, pain sensitivity intermediates between emotional states and personality traits, partially via elevated pain catastrophizing thoughts.


2020 ◽  
Vol 9 (11) ◽  
pp. 3564
Author(s):  
Luis Ceballos-Laita ◽  
María Teresa Mingo-Gómez ◽  
Francisco Navas-Cámara ◽  
Elena Estébanez-de-Miguel ◽  
Santos Caudevilla-Polo ◽  
...  

Background: We compared the effects of therapeutic exercise (TE) combined with pain neurophysiology education (PNE) to those of TE in isolation on pain intensity, general fibromyalgia impact, mechanical pain sensitivity, pain catastrophizing, psychological distress and quality of life in women with fibromyalgia syndrome (FMS). Methods: A feasibility study with a 3 month follow-up was designed. Thirty-two patients with FMS were randomly assigned to PNE + TE group (n = 16) or to TE group (n = 16). Both groups received 30 sessions of TE (3 per week), and the PNE + TE group received eight face-to-face educational sessions. The measuring instruments used were the visual analogue scale, a standard pressure algometer, the Revised Fibromyalgia Impact Questionnaire, the Pain Catastrophizing Scale, the Hospital Anxiety and Depression Scale and the Health Assessment Questionnaire. Results: The PNE + TE group showed a statistically significant decrease on pain intensity compared to TE group at short term (p = 0.015). No between-groups differences were found for mechanical pain sensitivity, general fibromyalgia impact, pain catastrophizing, psychological distress or quality of life (p > 0.05). Conclusions: The combination of PNE and TE was more effective than TE for reducing pain intensity in the short-term. No differences were found for psychological distress, pain catastrophizing and quality of life after the intervention or at 3 months of follow-up.


PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0253945
Author(s):  
Nadja Strandberg Kristensen ◽  
Emma Hertel ◽  
Camilla Hoffmeyer Skadhauge ◽  
Sissel Højsted Kronborg ◽  
Kristian Kjær Petersen ◽  
...  

Musculoskeletal pain affects approximately 20% of the population worldwide and represents one of the leading causes of global disability. As yet, precise mechanisms underlying the development of musculoskeletal pain and transition to chronicity remain unclear, though individual factors such as sleep quality, physical activity, affective state, pain catastrophizing and psychophysical pain sensitivity have all been suggested to be involved. This study aimed to investigate whether factors at baseline could predict musculoskeletal pain intensity to an experimental delayed onset of muscle soreness (DOMS) pain model. Demographics, physical activity, pain catastrophizing, affective state, sleep quality, isometric force production, temporal summation of pain, and psychophysical pain sensitivity using handheld and cuff algometry were assessed at baseline (Day-0) and two days after (Day-2) in 28 healthy participants. DOMS was induced on Day-0 by completing eccentric calf raises on the non-dominant leg to fatigue. On Day-2, participants rated pain on muscle contraction (visual analogue scale, VAS, 0-10cm) and function (Likert scale, 0–6). DOMS resulted in non-dominant calf pain at Day-2 (3.0±2.3cm), with significantly reduced isometric force production (P<0.043) and handheld pressure pain thresholds (P<0.010) at Day-2 compared to Day-0. Linear regression models using backward selection predicted from 39.3% (P<0.003) of VAS to 57.7% (P<0.001) of Likert score variation in DOMS pain intensity and consistently included cuff pressure pain tolerance threshold (P<0.01), temporal summation of pain (P<0.04), and age (P<0.02) as independent predictive factors. The findings indicate that age, psychological and central pain mechanistic factors are consistently associated with pain following acute muscle injury.


2012 ◽  
Vol 108 (8) ◽  
pp. 2276-2281 ◽  
Author(s):  
Emanuel N. van den Broeke ◽  
Casper H. van Heck ◽  
Linda A. J. M. Ceelen ◽  
Clementina M. van Rijn ◽  
Harry van Goor ◽  
...  

High-frequency conditioning electrical stimulation (HFS) of human skin induces an increased pain sensitivity to mechanical stimuli in the surrounding nonconditioned skin. The aim of this study was to investigate the effect of HFS on reported pain sensitivity to single electrical stimuli applied within the area of conditioning stimulation. We also investigated the central nervous system responsiveness to these electrical stimuli by measuring event-related potentials (ERPs). Single electrical test stimuli were applied in the conditioned area before and 30 min after HFS. During electrical test stimulation, the reported pain intensity (numerical rating scale) and EEG (ERPs) were measured. Thirty minutes after conditioning stimulation, we observed a decrease of reported pain intensity at both the conditioned and control (opposite arm) skin site in response to the single electrical test stimuli. In contrast, we observed enhanced ERP amplitudes after HFS at the conditioned skin site, compared with control site, in response to the single electrical test stimuli. Recently, it has been proposed that ERPs, at least partly, reflect a saliency detection system. Therefore, the enhanced ERPs might reflect enhanced saliency to potentially threatening stimuli.


Author(s):  
Ignacio Hernando-Garijo ◽  
Luis Ceballos-Laita ◽  
María Teresa Mingo-Gómez ◽  
Ricardo Medrano-de-la-Fuente ◽  
Elena Estébanez-de-Miguel ◽  
...  

Background: We analyzed the immediate effects of a Telerehabilitation Program (TP) based on aerobic exercise in women with fibromyalgia (FM) syndrome during the lockdown declared in Spain due to the COVID-19 pandemic. Methods: A single-blind randomized controlled trial was designed. Thirty-four women with FM were randomized into two groups: TP group and Control group. The intervention lasted 15 weeks, with 2 sessions per week. The TP based on aerobic exercise was guided by video and the intensity of each session was monitored using the Borg scale. Pain intensity (Visual Analogue Scale), mechanical pain sensitivity (algometer), number of tender points, FM impact (Revised Fibromyalgia Impact Questionnaire), pain catastrophizing (Pain Catastrophizing Scale), physiological distress (Hospital Anxiety and Depression Scale), upper (Arm Curl Test) and lower-limb physical function (6-min Walk Test) were measured at baseline and after the intervention. Results: The TP group improved pain intensity (p = 0.022), mechanical pain sensitivity (p < 0.05), and psychological distress (p = 0.005), compared to the Control group. The Control group showed no statistically significant changes in any variable (p > 0.05). Conclusions: A TP based on aerobic exercise achieved improvements on pain intensity, mechanical pain sensitivity, and psychological distress compared to a Control group during the lockdown declared in Spain due to COVID-19 pandemic.


2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 3-4
Author(s):  
Maria E Lou ◽  
Yuzhi Li ◽  
Beth Ventura

Abstract Castration without the use of analgesia is routinely performed on male piglets. The objective of this study was to assess acute pain during castration through behavioral indicators. Piglets (n=88) were randomly allocated to one of two treatments: castration without the use of analgesia (C) and sham-castration (S). Within 24 hours after birth (birth weight = 1.78kg ±0.71), identical procedures were followed for both treatment groups, except sham piglets were not castrated. Struggle behavior (curl ups, leg kicks, and body flailing) and vocalizations were collected via continuous video recording as piglets received treatment from start (first application of scalpel) to end (application of iodine). Vocalization parameters (duration and peak frequency) were analyzed using the Raven Pro: Interactive Sound Analysis Software (Version 1.5). Peak frequency was defined as low (&lt; 1000 Hz) and high (≥ 1000 Hz). Data were analyzed using the Glimmix Procedure of SAS. For struggle behavior, treatment did not affect curl up frequency. However, castrated piglets kicked more frequently than did sham piglets (C=28.8±0.9 vs. S=21.3±0.9 kicks/min; P=0.02). Additionally, 52% of castrated piglets displayed body flailing, whereas only 4.4% of sham piglets displayed the same behavior (Chi-Square = 24.2; P &lt; 0.0001). For vocalizations, no difference was found for duration and peak frequency of low frequency calls. However, castrated piglets responded with more high frequency calls than sham piglets (C=23.6±0.3 vs. S=18.6±0.3 calls/min; P=0.04). High frequency calls tended to be of longer duration for castrated piglets (C=0.45±0.04 vs. S=0.27±0.04 sec/call; P=0.08). Results indicate that castration without the use of analgesia increased the frequency of leg kicks, body failing, and high frequency calls. This suggests that leg kicks, body flailing, and high frequency calls maybe useful behavioral indicators of acute pain in piglets.


2020 ◽  
Vol 2 (1) ◽  
pp. 16-20
Author(s):  
Kimitoshi Noto ◽  
Michiro Yamamoto ◽  
Katsuyuki Iwatsuki ◽  
Shigeru Kurimoto ◽  
Masahiro Tatebe ◽  
...  

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