scholarly journals The Role of Frontal-Subcortical Circuitry in Neuropsychological Deficit of Attention: Hypothesis and Results in Two Coagulation Disorders

2016 ◽  
Vol 10 ◽  
Author(s):  
Silvia Riva ◽  
Serena Oliveri ◽  
Chiara Fioretti ◽  
Marianna Masiero ◽  
Gabriella Pravettoni
Keyword(s):  
Coagulation Disorders ◽  
Neuropsychological Deficit ◽  
Attention Hypothesis

IX international curse of continuing formation in haemophilia and other congenital coagulopathies. The role of the Laboratory in coagulation disorders. Diagnosis of von Willebrand disease

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Javier Batlle ◽  
Almudena Pérez-Rodríguez ◽  
Irene Corrales ◽  
Nina Borràs ◽  
Joana Costa Pinto ◽  
...  
Keyword(s):  
Von Willebrand Disease ◽  
Coagulation Disorders ◽  
Von Willebrand

Impact of Exercise/Sport on Well-being in Congenital Bleeding Disorders

2018 ◽  
Vol 44 (08) ◽  
pp. 796-801
Author(s):  
Silvia Fasoli ◽  
Giorgio Gandini ◽  
Anna Giuffrida ◽  
Massimo Franchini
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Well Being ◽  
The Other ◽  
Bleeding Disorders ◽  
Coagulation Disorders ◽  
Sporting Activity ◽  
The Impact

AbstractPhysical activity provides many benefits in patients with congenital bleeding disorders. Patients with hemophilia are encouraged to participate in exercise and sports, especially those patients receiving prophylaxis. Several publications and guidelines have explored this issue in hemophilia patients, evaluating in particular the impact of physical activity on patients' well-being and quality of life. The other rare congenital bleeding disorders are less studied; they are heterogeneous in terms of clinical bleeding phenotype, incidence of hemarthrosis, and arthropathy. Furthermore, prophylaxis in these patients is less common than in hemophilia patients, which must be considered when choosing the type of physical and sporting activity. In this review, the authors have analyzed the literature focusing their attention on those rare coagulation disorders that may be complicated by arthropathy and the role of exercise and sports in this context.

scholarly journals The role of coagulation disorders in patients with retinal vein occlusion

QJM ◽  
2015 ◽  
Vol 109 (2) ◽  
pp. 97-102 ◽  
Author(s):  
J.J. Napal ◽  
S. Neila ◽  
R. Pérez-Montes ◽  
I. Sierra ◽  
S. Ruiz ◽  
...  
Keyword(s):  
Retinal Vein Occlusion ◽  
Coagulation Disorders ◽  
Vein Occlusion

scholarly journals Coagulation Disorders in COVID-19: Role of Toll-like Receptors

2020 ◽  
Vol Volume 13 ◽  
pp. 823-828 ◽  
Author(s):  
Indranil Biswas ◽  
Gausal A Khan
Keyword(s):  
Coagulation Disorders ◽  
Toll Like Receptors

scholarly journals Role of COVID-19 in Hepatic Damage and Its Cellular Entrance and Mechanism of Action: A Mini-Review

2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Ali Akbar Oroojan
Keyword(s):  
Mechanism Of Action ◽  
Tissue Damage ◽  
Liver Tissue ◽  
Cellular Mechanism ◽  
Coagulation Disorders ◽  
Hepatocyte Apoptosis ◽  
Cardiorespiratory Failure ◽  
Pulmonary System ◽  
Review Study

Context: COVID-19 induces damage to the liver in addition to the pulmonary system. This event can alter hepatic biochemical and histological variables. Therefore, the present mini-review study investigated the effect of COVID-19 on hepatic damages and its cellular mechanism of action. Evidence Acquisition: In this mini-review study, the effects of COVID-19 on liver cells were sought in PubMed without restriction. The related components were searched in the Me SH term system and also used in two groups of COVID-19 and hepatocytes in combination with each other. Then, the titles and abstracts of the selected articles were assessed, and unrelated articles were removed. Results and Conclusion: COVID-19 leads to liver tissue damage and hepatocyte apoptosis by inducing increased cytokines, ischemia, and hepatic hypoxia following cardiorespiratory failure, coagulation disorders, and intracellular calcium. The SARS-CoV-2 virus exerts this effect through the ACE2 receptor and increasing its expression in cholangiocytes.

The role of recombinant activated factor VII in neurosurgery: hope or hype?

2006 ◽  
Vol 105 (6) ◽  
pp. 859-868 ◽  
Author(s):  
Gregory W. J. Hawryluk ◽  
Michael D. Cusimano
Keyword(s):  
Safety Information ◽  
Factor Vii ◽  
Coagulation Disorders ◽  
Clotting Factors ◽  
Recombinant Activated Factor Vii ◽  
Activated Factor Vii ◽  
Neurosurgical Patients ◽  
Perioperative Hemorrhage ◽  
Major Impediment

✓ Recombinant activated factor VII (rFVIIa) is a relatively new pharmaceutical agent developed for use in patients with hemophilia in whom inhibitors to clotting factors VIII or IX have developed. Use of this drug has become common in recent years because of its efficacy and safety in patients with coagulation disorders as well as in patients who are at high risk for thromboembolism, even when other means of establishing hemostasis have failed. The use of rFVIIa in neurosurgery has lagged behind its use in other fields, although there is a growing body of literature on such uses. In this article the authors review the history and science of rFVIIa as well as dosing and safety information. Various uses pertinent to the neurosurgeon are reviewed, including the treatment of patients with coagulation disorders, those suffering trauma, and those with perioperative hemorrhage, intracerebral hemorrhage, or subarachnoid hemorrhage. Based on their review of the uses of rFVIIa, the authors conclude that rFVIIa is a safe and effective agent with the potential to revolutionize the treatment of neurosurgical patients with hemorrhage. Cost is a major impediment to the widespread use of rFVIIa, and there is some evidence that its use in the neurosurgical population may be subject to higher risk than in other populations studied thus far. Although further study is needed to better delineate the safety and efficacy of the drug in many nonlicensed uses, it is clear that rFVIIa is an agent with tremendous promise.

scholarly journals Role of coagulopathy in glucocorticoid-induced osteonecrosis of the femoral head

2017 ◽  
Vol 46 (6) ◽  
pp. 2141-2148 ◽  
Author(s):  
Qiankun Zhang ◽  
Jin L v ◽  
Lie Jin
Keyword(s):  
Endothelial Cell ◽  
Femoral Head ◽  
Blood Supply ◽  
Fat Embolism ◽  
Aetiological Factor ◽  
Traditional Theory ◽  
Coagulation Disorders ◽  
Cell Dysfunction ◽  
Common Causes

The two major theories of glucocorticoid (GC)-induced osteonecrosis of the femoral head (ONFH) are apoptosis and ischaemia. The traditional theory implicates ischaemia as the main aetiological factor because the final common pathway of ONFH is interruption of blood supply to the bone. The most common causes of interruption of blood supply include fat embolism and coagulation disorders. GCs can directly or indirectly lead to coagulation disorders, producing a hypercoagulable state, followed by poor blood flow, ischaemia, and eventually ONFH. This review summarizes the existing knowledge on coagulation disorders in the context of GC-induced ONFH, including hypofibrinolysis and thrombophilia, endothelial cell dysfunction and damage, endothelial cell apoptosis, lipid metabolism, platelet activation, and the effect of anticoagulant treatment.

Role of dactinomycin in the improved survival of children with Wilms' tumor

JAMA ◽  
1966 ◽  
Vol 195 (12) ◽  
pp. 1005-1009 ◽  
Author(s):  
D. J. Fernbach
Keyword(s):  
Wilms Tumor
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