scholarly journals Serotonin receptor gene (HTR2A) T102C polymorphism modulates individuals’ perspective taking ability and autistic-like traits

2015 ◽  
Vol 9 ◽  
Author(s):  
Pingyuan Gong ◽  
Jinting Liu ◽  
Philip R. Blue ◽  
She Li ◽  
Xiaolin Zhou
Keyword(s):  
Perspective Taking ◽  
Serotonin Receptor ◽  
Receptor Gene ◽  
T102c Polymorphism

scholarly journals Potential Link between T102C Polymorphism in the Serotonin Receptors (5-HT2A) Gene and Treatment Response of Risperidone on Schizophrenia

2021 ◽  
Vol 9 (T3) ◽  
pp. 288-293
Author(s):  
Saidah Syamsuddin ◽  
Andi Fatimah ◽  
Faisal Idrus ◽  
Sonny T. Lisal
Keyword(s):  
Gene Polymorphism ◽  
Healthy Volunteers ◽  
Treatment Response ◽  
Serotonin Receptors ◽  
Serotonin Receptor ◽  
Receptor Gene ◽  
Significant Difference ◽  
Potential Link ◽  
Allele Specific ◽  
T102c Polymorphism

BACKGROUND: Schizophrenia affects 1% of population and its molecular etiology remains enigmatic despite enormous study. Approximately one-third of patients failed to respond with treatment. The 5-HT2A receptor appears to be one of important site of action of atypical antipsychotic drugs. It also has been suggested that the T102C gene polymorphism alters promoter activity and expression of 5-HT2A receptors and might be responsible for the associations with the efficacy of typical antipsychotics. AIM: In this study, we aimed to evaluate the potential link between T102C polymorphism in the Serotonin Receptors (5-HT2A) and their response to risperidone. METHODS: We studied 100 schizophrenia patients and 100 healthy volunteers as a comparison of 5-HT2A receptors gene polymorphism distribution, which were all Indonesian. The peripheral blood samples were obtained from all participants. The patients assessed by Positive and Negative Scale (PANSS) and Clinical Global Impression Scale (CGI) when admitted to the hospital. Clinical improvements then assessed 5 times in 4 weeks (when transferred to sub-acute ward, at the 1st, the 2nd, the 3rd, and the 4th week). To analyze the T102C polymorphism of 5-HT2A receptor gene, we used an allele specific polymerase chain reaction based restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: In this study, there were three various polymorphisms of T102C in the serotonin receptor (5-HT2A) gene: T/T, C/C, and T/C. The patients who had homozygous for T/T genotypes were found to give better improvement to risperidone than the patients who were C/C and T/C genotypes (P:0.001). Moreover, the patients with C allele genotype T/C and C/C had minimal response (P:0.001). We found no significant difference distribution of genotypes between schizophrenia patients and healthy volunteers (P:0.498). CONCLUSION: Our result supported that there was a potential link between T102C polymorphism in the serotonin receptor (5-HT2A) gene and treatment response of risperidone. It suggested the importance of genetic screening such as examination of the Serotonin Receptor 5-HT2A (T102C) gene polymorphism to be performed to optimize therapeutic strategies with antipsychotic.

scholarly journals The Association between the T102C Polymorphism of the HTR2A Serotonin Receptor Gene and HDL Cholesterol Level in Koreans

BMB Reports ◽  
2005 ◽  
Vol 38 (2) ◽  
pp. 238-242 ◽  
Author(s):  
Jin-Ho Choi ◽  
Shu-Ying Zhang ◽  
Kyung-Woo Park ◽  
Young-Seok Cho ◽  
Byung-Hee Oh ◽  
...  
Keyword(s):  
Cholesterol Level ◽  
Serotonin Receptor ◽  
Receptor Gene ◽  
Hdl Cholesterol ◽  
T102c Polymorphism

Role of 5-HT2A Receptor Gene T102C Polymorphism in Coronary Artery Disease and Serum Lipid Level

2003 ◽  
Vol 33 (4) ◽  
pp. 269
Author(s):  
Jin Ho Choi ◽  
Shu Ying Zhang ◽  
Young Seok Cho ◽  
Kyoung Kook Whang ◽  
Jun Hee Lee ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Lipid ◽  
Lipid Level ◽  
Receptor Gene ◽  
Serum Lipid Level ◽  
T102c Polymorphism ◽  
Artery Disease

T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction

2000 ◽  
Vol 150 (1) ◽  
pp. 143-148 ◽  
Author(s):  
Shinichiro Yamada ◽  
Hozuka Akita ◽  
Kenji Kanazawa ◽  
Tatsuro Ishida ◽  
Ken-ichi Hirata ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Receptor Gene ◽  
T102c Polymorphism

scholarly journals Genetic variation in the serotonin receptor gene affects immune responses

2012 ◽  
Vol 71 (Suppl 1) ◽  
pp. A93-A93
Author(s):  
Omri Snir ◽  
Espen Hesselberg ◽  
Petra Amoudrouz ◽  
Lars Klareskog ◽  
Lars Alfredsson ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Immune Responses ◽  
Serotonin Receptor ◽  
Receptor Gene

Two Naturally Occurring Variants of the Serotonin Receptor Gene HTR3C Are Associated With Nausea in Pregnancy

2011 ◽  
Vol 31 (2) ◽  
pp. 114
Author(s):  
T.W. Goecke ◽  
A.B. Ekici ◽  
B. Niesler ◽  
C.R. Loehberg ◽  
C. Hammer ◽  
...  
Keyword(s):  
Serotonin Receptor ◽  
Receptor Gene ◽  
Naturally Occurring ◽  
In Pregnancy

T102C and –1438 G/A polymorphisms of the 5-HT2A receptor gene in Turkish patients with obsessive–compulsive disorder

2003 ◽  
Vol 18 (5) ◽  
pp. 249-254 ◽  
Author(s):  
Şenel Tot ◽  
M. Emin Erdal ◽  
Kemal Yazıcı ◽  
Aylin Ertekin Yazıcı ◽  
Özmen Metin
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Receptor Gene ◽  
Clinical Severity ◽  
Genotype Distribution ◽  
Healthy Controls ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Increased Risk ◽  
T102c Polymorphism ◽  
Turkish Patients

AbstractObjectiveThis study aimed to investigate the possible association between T102C and –1438 G/A polymorphism in the 5-HT2A receptor gene and susceptibility to and clinical features of obsessive–compulsive disorder (OCD).MethodFifty-eight patients with OCD and 83 healthy controls were included in the study. All patients were interviewed and rated by Yale-Brown Obsessive–Compulsive Scale. T102C and –1438 G/A polymorphisms of 5-HT2A receptor gene were determined by PCR technique in DNAs of peripheral leucocytes.ResultsOCD patients and healthy controls did not show significant differences in genotype distribution for both polymorphisms investigated. We found that frequencies of the TT genotype for T102C polymorphism and the AA genotype for –1438 G/A polymorphism were significantly higher in patients with severe OCD compared to those with moderate or moderate–severe OCD.ConclusionThe –1438 G/A and T102C polymorphisms of the 5-HT2A receptor gene are not associated with an increased risk of OCD. Our data suggest that the TT genotype of T102C and the AA genotype of –1438 G/A polymorphism might be a factor in clinical severity of OCD.

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