scholarly journals Neural Mechanisms Underlying Perilesional Transcranial Direct Current Stimulation in Aphasia: A Feasibility Study

2015 ◽  
Vol 9 ◽  
Author(s):  
Lena Ulm ◽  
Katie McMahon ◽  
David Copland ◽  
Greig I. de Zubicaray ◽  
Marcus Meinzer
Keyword(s):  
Feasibility Study ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Neural Mechanisms ◽  
Direct Current Stimulation

scholarly journals Exploring the neural, behavioural, and clinical effects of transcranial direct current stimulation in patients with a Prolonged Disorder of Consciousness; protocol for a double-blind randomised crossover feasibility study

2020 ◽  
Author(s):  
Davinia Fernández-Espejo ◽  
Davide Aloi ◽  
Antonio Incisa della Rocchetta ◽  
Damon Hoad ◽  
Richard Greenwood ◽  
...  
Keyword(s):  
Individual Differences ◽  
Feasibility Study ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Brain Activity ◽  
Brain Structures ◽  
Clinical Effects ◽  
Disorder Of Consciousness ◽  
Double Blind ◽  
Direct Current Stimulation

Abstract Background: Therapeutic options for patients with prolonged disorders of consciousness (PDOC) are very limited, and patients often show little to no progress over time. It is widely recognized that some PDOC patients retain a higher level of cognition that may be apparent on the basis of their external responses, and simply are unable to produce purposeful motor behaviours. This dissociation has been linked to specific impairments in the motor network that lead to a reduction in thalamo-cortical coupling. Here, we will assess whether transcranial direct current stimulation (tDCS) can modulate thalamo-cortical coupling and improve patients’ responsiveness. We will focus on characterising the mechanisms of action of tDCS and the bases for potential individual differences in responsiveness to the stimulation across participants.Methods: This is a multi-centre double-blind randomised crossover feasibility study. It is divided into two streams: (a) MRI stream: 5 PDOC patients will complete 5 anodal, cathodal, and sham stimulation sessions (paired with passive mobilisation of the thumb) in separate weeks. We will measure brain activity and connectivity with functional magnetic resonance imaging and electroencephalography (EEG). We will look at brain structures to assess differences associated with responsiveness. (b) Bedside stream: 10 patients will complete one session of anodal or cathodal stimulation and one session of sham. We will measure brain activity and connectivity with EEG and we will conduct follow up assessments at 3 and 6 months. In both streams we will also look at changes in the clinical profile of patients with the Coma Recovery Scale Revised and in command following behaviour with electromyography and motion tracking. We will assess feasibility on measures of eligibility, recruitment, retention, and completion of tests.Discussion: This feasibility study is the first step towards developing personalised tDCS interventions to restore external responsiveness in PDOC patients. Our results will inform the design of a future trial fully powered for characterising neural, behavioural, and clinical effects of tDCS in PDOC as well as the mechanisms underlying individual differences in responsiveness.

scholarly journals Transcranial direct current stimulation for online gamers: A prospective single-arm feasibility study

2018 ◽  
Vol 7 (4) ◽  
pp. 1166-1170 ◽  
Author(s):  
Sang Hoon Lee ◽  
Jooyeon Jamie Im ◽  
Jin Kyoung Oh ◽  
Eun Kyoung Choi ◽  
Sujung Yoon ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

scholarly journals Transcranial direct current stimulation to the parietal cortex in hemispatial neglect: A feasibility study

2015 ◽  
Vol 74 ◽  
pp. 152-161 ◽  
Author(s):  
Miranda Smit ◽  
Dennis J.L.G. Schutter ◽  
Tanja C.W. Nijboer ◽  
Johanna M.A. Visser-Meily ◽  
L. Jaap Kappelle ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Parietal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Hemispatial Neglect ◽  
Direct Current Stimulation

Abstract #111: Transcranial Direct Current Stimulation (tDCS) in Cerebral Palsy: Open-label Safety and Feasibility Study

2019 ◽  
Vol 12 (2) ◽  
pp. e38
Author(s):  
Leon Morales-Quezada ◽  
Mirret M. El-Hagrassy ◽  
Cristina Russo ◽  
Ana Luiza Zaninotto ◽  
Camila Bonin Pinto ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Feasibility Study ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Open Label ◽  
Direct Current Stimulation
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