scholarly journals Cerebellum to motor cortex paired associative stimulation induces bidirectional STDP-like plasticity in human motor cortex

2012 ◽  
Vol 6 ◽  
Author(s):  
Ming-Kuei Lu ◽  
Chon-Haw Tsai ◽  
Ulf Ziemann
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor

scholarly journals Effect of Serotonin on Paired Associative Stimulation-Induced Plasticity in the Human Motor Cortex

2013 ◽  
Vol 38 (11) ◽  
pp. 2260-2267 ◽  
Author(s):  
Giorgi Batsikadze ◽  
Walter Paulus ◽  
Min-Fang Kuo ◽  
Michael A Nitsche
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor

scholarly journals Efficacy and Interindividual Variability in Motor-Cortex Plasticity following Anodal tDCS and Paired-Associative Stimulation

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Wolfgang Strube ◽  
Tilmann Bunse ◽  
Berend Malchow ◽  
Alkomiet Hasan
Keyword(s):  
Motor Cortex ◽  
Cortical Excitability ◽  
Response Variability ◽  
Significant Group ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Excitability Change ◽  
Human Motor ◽  
Baseline Values

Interindividual response variability to various motor-cortex stimulation protocols has been recently reported. Comparative data of stimulation protocols with different modes of action is lacking. We aimed to compare the efficacy and response variability of two LTP-inducing stimulation protocols in the human motor cortex: anodal transcranial direct current stimulation (a-tDCS) and paired-associative stimulation (PAS25). In two experiments 30 subjects received 1mA a-tDCS and PAS25. Data analysis focused on motor-cortex excitability change and response defined as increase in MEP applying different cut-offs. Furthermore, the predictive pattern of baseline characteristics was explored. Both protocols induced a significant increase in motor-cortical excitability. In the PAS25 experiments the likelihood to develop a MEP response was higher compared to a-tDCS, whereas for intracortical facilitation (ICF) the likelihood for a response was higher in the a-tDCS experiments. Baseline ICF (12 ms) correlated positively with an increase in MEPs only following a-tDCS and responders had significantly higher ICF baseline values. Contrary to recent studies, we showed significant group-level efficacy following both stimulation protocols confirming older studies. However, we also observed a remarkable amount of nonresponders. Our findings highlight the need to define sufficient physiological read-outs for a given plasticity protocol and to develop predictive markers for targeted stimulation.

scholarly journals Inducing LTD-Like Effect in the Human Motor Cortex with Low Frequency and Very Short Duration Paired Associative Stimulation: An Exploratory Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Prachaya Srivanitchapoom ◽  
Jung E. Park ◽  
Nivethida Thirugnanasambandam ◽  
Pattamon Panyakaew ◽  
Vesper Fe Marie Ramos ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Motor Cortex ◽  
Short Duration ◽  
Repeated Measures ◽  
Low Frequency ◽  
Long Term Potentiation ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor

Introduction.Paired associative stimulation (PAS) is an established technique to investigate synaptic plasticity in the human motor cortex (M1). Classically, to induce long-term depression- (LTD-) or long-term potentiation-like effects in the human M1, studies have used low frequency and long duration trains of PAS. In the present study, we explored an LTD-like effect using very short duration and low frequency ofPAS10 msprotocols in human M1.Methods.Six protocols of low frequencyPAS10 ms(ranging from 0.2 Hz to 1 Hz) were investigated with very short durations of 1 and 2 minutes stimulation. Six healthy volunteers were included in each protocol. We obtained motor-evoked potentials from right abductor pollicis brevis muscle before and after applyingPAS10 msup to 30 minutes. After we foundPAS10 msprotocol which induced an LTD-like effect, we tested that protocol on additional 5 subjects.Results.One-way repeated-measures ANOVA showed that only the group of 1-minute stimulation of 0.25 Hz induced an LTD-like effect. When adding the additional subjects, the effect remained and lasted for 30 minutes.Conclusion.Low frequency and very short duration ofPAS10 mspotentially induced an LTD-like effect in human M1. With further verification, this method might be useful for research relating to synaptic plasticity by reducing the duration of study and minimizing subject discomfort.

P14.6 Intracortical paired associative stimulation in the human motor cortex

2011 ◽  
Vol 122 ◽  
pp. S122
Author(s):  
M. Hamada ◽  
N. Murase ◽  
A. Hasan ◽  
M. Balaratnam ◽  
J. Rothwell
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor

scholarly journals Augmenting LTP-Like Plasticity in Human Motor Cortex by Spaced Paired Associative Stimulation

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0131020 ◽  
Author(s):  
Florian Müller-Dahlhaus ◽  
Caroline Lücke ◽  
Ming-Kuei Lu ◽  
Noritoshi Arai ◽  
Anna Fuhl ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor

scholarly journals Paired Associative Stimulation of Left and Right Human Motor Cortex Shapes Interhemispheric Motor Inhibition based on a Hebbian Mechanism

2008 ◽  
Vol 19 (4) ◽  
pp. 907-915 ◽  
Author(s):  
V. Rizzo ◽  
H.S. Siebner ◽  
F. Morgante ◽  
C. Mastroeni ◽  
P. Girlanda ◽  
...  
Keyword(s):  
Motor Cortex ◽  
Motor Inhibition ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Human Motor ◽  
Left And Right ◽  
Stimulation Of

scholarly journals Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation

2002 ◽  
Vol 543 (2) ◽  
pp. 699-708 ◽  
Author(s):  
Katja Stefan ◽  
Erwin Kunesch ◽  
Reiner Benecke ◽  
Leonardo G. Cohen ◽  
Joseph Classen
Keyword(s):  
Motor Cortex ◽  
Paired Associative Stimulation ◽  
Human Motor Cortex ◽  
Motor Cortex Excitability ◽  
Human Motor
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