scholarly journals Desynchronizing electrical and sensory coordinated reset neuromodulation

2012 ◽  
Vol 6 ◽  
Author(s):  
Oleksandr V. Popovych ◽  
Peter A. Tass
Keyword(s):  
Coordinated Reset

scholarly journals Treatment Tone Spacing and Acute Effects of Acoustic Coordinated Reset Stimulation in Tinnitus Patients

2021 ◽  
Vol 1 ◽  
Author(s):  
Tina Munjal ◽  
Alexander N. Silchenko ◽  
Kristina J. Pfeifer ◽  
Summer S. Han ◽  
Jessica K. Yankulova ◽  
...  
Keyword(s):  
Animal Studies ◽  
Symptomatic Improvement ◽  
Center Frequency ◽  
Acute Effects ◽  
Stimulus Amplitude ◽  
Neuronal Populations ◽  
Experimental Protocols ◽  
Relationship Of ◽  
The Impact ◽  
Coordinated Reset

Acoustic coordinated reset (aCR) therapy for tinnitus aims to desynchronize neuronal populations in the auditory cortex that exhibit pathologically increased coincident firing. The original therapeutic paradigm involves fixed spacing of four low-intensity tones centered around the frequency of a tone matching the tinnitus pitch, fT, but it is unknown whether these tones are optimally spaced for induction of desynchronization. Computational and animal studies suggest that stimulus amplitude, and relatedly, spatial stimulation profiles, of coordinated reset pulses can have a major impact on the degree of desynchronization achievable. In this study, we transform the tone spacing of aCR into a scale that takes into account the frequency selectivity of the auditory system at each therapeutic tone’s center frequency via a measure called the gap index. Higher gap indices are indicative of more loosely spaced aCR tones. The gap index was found to be a significant predictor of symptomatic improvement, with larger gap indices, i.e., more loosely spaced aCR tones, resulting in reduction of tinnitus loudness and annoyance scores in the acute stimulation setting. A notable limitation of this study is the intimate relationship of hearing impairment with the gap index. Particularly, the shape of the audiogram in the vicinity of the tinnitus frequency can have a major impact on tone spacing. However, based on our findings we suggest hypotheses-based experimental protocols that may help to disentangle the impact of hearing loss and tone spacing on clinical outcome, to assess the electrophysiologic correlates of clinical improvement, and to elucidate the effects following chronic rather than acute stimulation.

scholarly journals Rebuttal to reply by G. Rücker and G. Antes on Tass et al. “Counteracting tinnitus by acoustic coordinated reset neuromodulation”, Restorative Neurology and Neuroscience Vol. 30(2), 2012

2013 ◽  
Vol 31 (3) ◽  
pp. 235-237 ◽  
Author(s):  
Peter A. Tass ◽  
Ilya Adamchic ◽  
Hans-Joachim Freund ◽  
Tatjana von Stackelberg ◽  
Christian Hauptmann
Keyword(s):  
Coordinated Reset

Sustained Reduction of Parkinsonian Symptoms After “Coordinated Reset” Neuromodulation

Neurosurgery ◽  
2013 ◽  
Vol 72 (4) ◽  
pp. N22-N23
Author(s):  
Nathan T. Zwagerman ◽  
Robert S. Turner ◽  
R. Mark Richardson
Keyword(s):  
Sustained Reduction ◽  
Coordinated Reset

scholarly journals Coordinated reset neuromodulation for Parkinson's disease: Proof‐of‐concept study

2014 ◽  
Vol 29 (13) ◽  
pp. 1679-1684 ◽  
Author(s):  
Ilya Adamchic ◽  
Christian Hauptmann ◽  
Utako Brigit Barnikol ◽  
Norbert Pawelczyk ◽  
Oleksandr Popovych ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Proof Of Concept ◽  
Concept Study ◽  
Coordinated Reset

scholarly journals Acoustic Coordinated Reset Neuromodulation in a Real Life Patient Population with Chronic Tonal Tinnitus

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Christian Hauptmann ◽  
Armin Ströbel ◽  
Mark Williams ◽  
Nitesh Patel ◽  
Hannes Wurzer ◽  
...  
Keyword(s):  
Real Life ◽  
Negative Influence ◽  
Tinnitus Questionnaire ◽  
Open Label ◽  
Safety And Efficacy ◽  
Life Conditions ◽  
Real Life Setting ◽  
Clinically Significant ◽  
Coordinated Reset

Purpose. Primary tinnitus has a severe negative influence on the quality of life of a significant portion of the general population. Acoustic coordinated reset neuromodulation is designed to induce a long-lasting reduction of tinnitus symptoms. To test acoustic coordinated reset neuromodulation as a treatment for chronic, tonal tinnitus under real life conditions, an outpatient study “RESET Real Life” was commissioned by ANM GmbH. Herein we present the results of this study.Methods. In a prospective, open-label, nonrandomized, noncontrolled multicenter clinical study with 200 chronic tinnitus patients, tinnitus questionnaire TBF-12 and Global Clinical Improvement-Impression Scale (CGI-I7) are used to study the safety and efficacy of acoustic coordinated reset neuromodulation. 189 patients completed the last 12-month visit, 11 patients dropped out (8 because of nontreatment related reasons; 2 because tinnitus did not change; and 1 because tinnitus got louder).Results. Acoustic coordinated reset neuromodulation caused a statistically and clinically significant decrease in TBF-12 scores as well as in CGI-I7 after 12 months of therapy under real life conditions. There were no persistent adverse events reported that were related to the therapy.Conclusion. The field study “RESET Real Life” provides evidence for safety and efficacy of acoustic coordinated reset neuromodulation in a prospective, open-label, real life setting.

scholarly journals Multi-frequency activation of neuronal networks by coordinated reset stimulation

2010 ◽  
Vol 1 (1) ◽  
pp. 75-85 ◽  
Author(s):  
Borys Lysyansky ◽  
Oleksandr V. Popovych ◽  
Peter A. Tass
Keyword(s):  
Firing Rate ◽  
Neuronal Networks ◽  
Epileptic Seizures ◽  
Neuronal Population ◽  
Arnold Tongues ◽  
Clustering Pattern ◽  
Coordinated Reset

We computationally study whether it is possible to stimulate a neuronal population in such a way that its mean firing rate increases without an increase of the population's net synchronization. For this, we use coordinated reset (CR) stimulation, which has previously been developed to desynchronize populations of oscillatory neurons. Intriguingly, delivered to a population of predominantly silent FitzHugh–Nagumo or Hindmarsh–Rose neurons at sufficient stimulation amplitudes, CR robustly causes a multi-frequency activation: different Arnold tongues such as 1 : 1 or n  :  m entrained neuronal clusters emerge, which consist of phase-shifted sub clusters. Owing to the clustering pattern the neurons' timing is well balanced, so that in total there is no synchronization. Our findings may contribute to the development of novel and safe stimulation treatments that specifically counteract cerebral hypo-activity without promoting pathological synchronization or inducing epileptic seizures.

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