scholarly journals Computational Modeling of Single Neuron Extracellular Electric Potentials and Network Local Field Potentials using LFPsim

2016 ◽  
Vol 10 ◽  
Author(s):  
Harilal Parasuram ◽  
Bipin Nair ◽  
Egidio D'Angelo ◽  
Michael Hines ◽  
Giovanni Naldi ◽  
...  
Keyword(s):  
Computational Modeling ◽  
Local Field ◽  
Single Neuron ◽  
Local Field Potentials ◽  
Field Potentials ◽  
Electric Potentials

Concomitant Single Neuron Activity, Local Field Potentials, and Cerebral Microdialysis in Neurosurgical Patients

Neurosurgery ◽  
1998 ◽  
Vol 43 (3) ◽  
pp. 706-706 ◽  
Author(s):  
Itzhak Fried ◽  
Eric Behnke ◽  
Nigel Maidment ◽  
Anatole Bragin ◽  
Katherine MacDonald ◽  
...  
Keyword(s):  
Local Field ◽  
Single Neuron ◽  
Local Field Potentials ◽  
Cerebral Microdialysis ◽  
Neuron Activity ◽  
Field Potentials ◽  
Neurosurgical Patients ◽  
Single Neuron Activity

scholarly journals Modelling unitary fields and the single‐neuron contribution to local field potentials in the hippocampus

2020 ◽  
Vol 598 (18) ◽  
pp. 3957-3972 ◽  
Author(s):  
Maria Teleńczuk ◽  
Bartosz Teleńczuk ◽  
Alain Destexhe
Keyword(s):  
Local Field ◽  
Single Neuron ◽  
Local Field Potentials ◽  
Field Potentials

scholarly journals Altered Emotional Phenotypes in Chronic Kidney Disease Following 5/6 Nephrectomy

2021 ◽  
Vol 11 (7) ◽  
pp. 882
Author(s):  
Yeon Hee Yu ◽  
Seong-Wook Kim ◽  
Dae-Kyoon Park ◽  
Ho-Yeon Song ◽  
Duk-Soo Kim ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Local Field ◽  
Smooth Muscle Actin ◽  
Local Field Potentials ◽  
Renal Tissue ◽  
Field Potentials ◽  
Wild Type ◽  
Sprague Dawley ◽  
Rat Models

Increased prevalence of chronic kidney disease (CKD) and neurological disorders including cerebrovascular disease, cognitive impairment, peripheral neuropathy, and dysfunction of central nervous system have been reported during the natural history of CKD. Psychological distress and depression are serious concerns in patients with CKD. However, the relevance of CKD due to decline in renal function and the pathophysiology of emotional deterioration is not clear. Male Sprague Dawley rats were divided into three groups: sham control, 5/6 nephrectomy at 4 weeks, and 5/6 nephrectomy at 10 weeks. Behavior tests, local field potentials, and histology and laboratory tests were conducted and investigated. We provided direct evidence showing that CKD rat models exhibited anxiogenic behaviors and depression-like phenotypes, along with altered hippocampal neural oscillations at 1–12 Hz. We generated CKD rat models by performing 5/6 nephrectomy, and identified higher level of serum creatinine and blood urea nitrogen (BUN) in CKD rats than in wild-type, depending on time. In addition, the level of α-smooth muscle actin (α-SMA) and collagen I for renal tissue was markedly elevated, with worsening fibrosis due to renal failures. The level of anxiety and depression-like behaviors increased in the 10-week CKD rat models compared with the 4-week rat models. In the recording of local field potentials, the power of delta (1–4 Hz), theta (4–7 Hz), and alpha rhythm (7–12 Hz) was significantly increased in the hippocampus of CKD rats compared with wild-type rats. Together, our findings indicated that anxiogenic behaviors and depression can be induced by CKD, and these abnormal symptoms can be worsened as the onset of CKD was prolonged. In conclusion, our results show that the hippocampus is vulnerable to uremia.

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