scholarly journals Decoding Subjective Intensity of Nociceptive Pain from Pre-stimulus and Post-stimulus Brain Activities

2016 ◽  
Vol 10 ◽  
Author(s):  
Yiheng Tu ◽  
Ao Tan ◽  
Yanru Bai ◽  
Yeung Sam Hung ◽  
Zhiguo Zhang
Keyword(s):  
Nociceptive Pain ◽  
Subjective Intensity

Neural and sociocultural mediators of ethnic differences in pain

2020 ◽  
Author(s):  
EAR Losin ◽  
CW Woo ◽  
NA Medina ◽  
JR Andrews-Hanna ◽  
Hedwig Eisenbarth ◽  
...  
Keyword(s):  
African Americans ◽  
Ethnic Differences ◽  
Nociceptive Pain ◽  
Common Belief ◽  
Pain Mechanisms ◽  
Thermal Pain ◽  
Heat Effects ◽  
Pain Report ◽  
And Gender ◽  
Ethnicity And Gender

© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Understanding ethnic differences in pain is important for addressing disparities in pain care. A common belief is that African Americans are hyposensitive to pain compared to Whites, but African Americans show increased pain sensitivity in clinical and laboratory settings. The neurobiological mechanisms underlying these differences are unknown. We studied an ethnicity- and gender-balanced sample of African Americans, Hispanics and non-Hispanic Whites using functional magnetic resonance imaging during thermal pain. Higher pain report in African Americans was mediated by discrimination and increased frontostriatal circuit activations associated with pain rating, discrimination, experimenter trust and extranociceptive aspects of pain elsewhere. In contrast, the neurologic pain signature, a neuromarker sensitive and specific to nociceptive pain, mediated painful heat effects on pain report largely similarly in African American and other groups. Findings identify a brain basis for higher pain in African Americans related to interpersonal context and extranociceptive central pain mechanisms and suggest that nociceptive pain processing may be similar across ethnicities.

Ropivacaine magnetic nanoparticles: An efficient local anesthetic nerve conduction blocker

2021 ◽  
Vol 11 (11) ◽  
pp. 1819-1825
Author(s):  
Junying Su ◽  
Xiaohu Chen ◽  
Huizhang Liu ◽  
Yuhui Luo
Keyword(s):  
Magnetic Nanoparticles ◽  
Postoperative Analgesia ◽  
Local Anesthetic ◽  
Temperature Response ◽  
Nociceptive Pain ◽  
Nerve Blocks ◽  
Anesthetic Effect ◽  
Field Of Vision ◽  
Clinical Anesthesia ◽  
The Stability

Ropivacaine (Rop) is one of the commonly used local nerve blocks in clinical anesthesia and postoperative analgesia and it inhibits the stimulation of peripheral nociceptive pain. However, Rop alone is not effective enough to exert a controllable anesthetic effect in patients with peripheral nociceptive pain. Therefore, there is an urgent need to improve the targeting of the local anesthetic effect of Rop and reduce its potential chronic or acute toxicity. In this study, a novel Rop nanocomposite hydrogel drug, N-isopropylacrylamide-methacrylic acid/ropivacaine magnetic nanoparticles (NIP-MAA/Rop MNPs), was constructed on magnetic iron oxide. The unique pH and temperature response of NIP-MAA can effectively retain magnetic properties, improve the stability and targeting controllability of magnetic nanoparticles, and avoid excessive drug diffusion. Therefore, the NIP-MAA/Rop MNPs is expected to open a new field of vision for the research of clinical anesthesia and postoperative analgesia.

PROMIS® Neuropathic and Nociceptive Pain Quality in Musculoskeletal Pain Presentations

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Brett Vaughan ◽  
Briony Chase ◽  
John Hickey ◽  
Mary Tassoulas ◽  
Harrison Weston ◽  
...  
Keyword(s):  
Musculoskeletal Pain ◽  
Nociceptive Pain

scholarly journals Assessment of subjective intensity of pain during ultrasonic supragingival calculus removal: A comparative study

2014 ◽  
Vol 18 (4) ◽  
pp. 472
Author(s):  
Sachin Malagi ◽  
Kirti Pattanshetti ◽  
Radhika Bharmappa ◽  
AnnajiSreedhara Reddy ◽  
Jagadish Pai ◽  
...  
Keyword(s):  
Comparative Study ◽  
Subjective Intensity

Positron emission tomographic analysis of cerebral structures activated specifically by repetitive noxious heat stimuli

1994 ◽  
Vol 71 (2) ◽  
pp. 802-807 ◽  
Author(s):  
K. L. Casey ◽  
S. Minoshima ◽  
K. L. Berger ◽  
R. A. Koeppe ◽  
T. J. Morrow ◽  
...  
Keyword(s):  
A Priori ◽  
Estimation Procedure ◽  
Subjective Rating ◽  
Positron Emission Tomographic ◽  
Noxious Heat ◽  
Heat Sensation ◽  
Medial Dorsal ◽  
Subjective Intensity ◽  
Positron Emission ◽  
Tomographic Analysis

1. To identify the forebrain and brain stem structures that are active during the perception of acute heat pain in humans, we performed H2 15O positron emission tomographic (PET) analyses of cerebral blood flow (CBF) on nine normal volunteers while they received repetitive noxious (50 degrees C) and innocuous (40 degrees C) 5 s heat pulses to the forearm (average resting temperature of 31.8 degrees C). Each subject rated the subjective intensity of each stimulation series according to a magnitude estimation procedure in which 0 = no heat sensation, 7 = barely painful, and 10 = barely tolerable. 2. Three scans were performed at each temperature. Mean CBF images were created for each experimental condition and oriented onto standardized stereotaxic coordinates. Subtraction images were created between conditions for each subject and averaged across subjects. Volumes of interest (VOI) were chosen, based on a priori hypotheses and the results of previously published PET studies. In addition, a separate statistical summation analysis of individual voxels was performed. Statistical thresholds were established with corrections for multiple comparisons. 3. Significant CBF increases to 50 degrees C stimuli were found in the contralateral thalamus, cingulate cortex, S2 and S1 cortex, and insula. The ipsilateral S2 cortex and thalamus, and the medial dorsal midbrain and cerebellar vermis also showed significant CBF increases. All subjects rated the 50 degrees C stimuli as painful (average subjective rating = 8.9 +/- 0.9 SD) and the 40 degrees C stimuli as warm, but not painful (average subjective rating = 2.1 +/- 1.0).(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Can Prevent Severe Postoperative Pain: A Retrospective Chart Review

Life ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 92
Author(s):  
Rikuhei Tsuchida ◽  
Masahiko Sumitani ◽  
Hiroaki Abe ◽  
Masae Ando ◽  
Kosuke Saita ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Abdominal Surgery ◽  
Chart Review ◽  
Stable State ◽  
Analgesic Efficacy ◽  
Retrospective Chart Review ◽  
Treated Group ◽  
P2y12 Receptor ◽  
Nociceptive Pain ◽  
P Value

The purinergic P2Y12 receptor regulates microglial activation, resulting in persistence and aggravation of pain in neuropathic and nociceptive pain models. We conducted a retrospective chart review to explore the analgesic potency of the P2Y12 receptor-specific antagonist, clopidogrel, for clinical management of postoperative pain in patients who underwent abdominal surgery. Twenty-seven patients with cardiovascular comorbidities, who underwent laparoscopic abdominal surgery and had ceased aspirin (ASP, n = 17) or clopidogrel (CLP, n = 10) for 14 days pre-operatively, were enrolled retrospectively. In both groups, the number of opioids and non-steroidal anti-inflammatory drugs (NSAIDs) consumed for managing postoperative pain was compared using the chi-square test and Mann–Whitney test. Our results showed that from postoperative day (POD) 0 to POD 3, the average numerical rating reflecting the postoperative pain was comparable between the two groups (CLP: 4.0 ± 1.4 vs. ASP: 3.7 ± 0.8, P-value = 0.56). However, at POD 7, opioid consumption in the CLP-treated group (fentanyl-equivalent dose: 0.49 ± 0.56 mg) was significantly lower than that in the ASP-treated group (1.48 ± 1.35 mg, P-value = 0.037). After reaching a stable state by repeated systemic administration, clopidogrel sustained the analgesic efficacy for a certain period. In conclusion, microglial P2Y12 receptors may mediate signal transduction of postoperative nociceptive pain and enhance clinical opioid analgesia.

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