scholarly journals Dopamine Modulates Delta-Gamma Phase-Amplitude Coupling in the Prefrontal Cortex of Behaving Rats

2017 ◽  
Vol 11 ◽  
Author(s):  
Victoria Andino-Pavlovsky ◽  
Annie C. Souza ◽  
Robson Scheffer-Teixeira ◽  
Adriano B. L. Tort ◽  
Roberto Etchenique ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Gamma Phase ◽  
Phase Amplitude

scholarly journals Can Oscillatory Alpha-Gamma Phase-Amplitude Coupling be Used to Understand and Enhance TMS Effects?

2019 ◽  
Vol 13 ◽  
Author(s):  
Johanna Wagner ◽  
Scott Makeig ◽  
David Hoopes ◽  
Mateusz Gola
Keyword(s):  
Gamma Phase ◽  
Phase Amplitude

scholarly journals Shifted phase of EEG cross-frequency coupling in individuals with Phelan-McDermid syndrome

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Michael. G. Mariscal ◽  
◽  
Elizabeth Berry-Kravis ◽  
Joseph D. Buxbaum ◽  
Lauren E. Ethridge ◽  
...  
Keyword(s):  
Repetitive Behavior ◽  
Rare Condition ◽  
Autism Spectrum ◽  
Gamma Phase ◽  
Typically Developing ◽  
Compulsive Behaviors ◽  
Phase Bias ◽  
Frequency Coupling ◽  
Phase Amplitude ◽  
Cross Frequency Coupling

Abstract Background Phelan-McDermid Syndrome (PMS) is a rare condition caused by deletion or mutation of the SHANK3 gene. Individuals with PMS frequently present with intellectual disability, autism spectrum disorder, and other neurodevelopmental challenges. Electroencephalography (EEG) can provide a window into network-level function in PMS. Methods Here, we analyze EEG data collected across multiple sites in individuals with PMS (n = 26) and typically developing individuals (n = 15). We quantify oscillatory power, alpha-gamma phase-amplitude coupling strength, and phase bias, a measure of the phase of cross frequency coupling thought to reflect the balance of feedforward (bottom-up) and feedback (top-down) activity. Results We find individuals with PMS display increased alpha-gamma phase bias (U = 3.841, p < 0.0005), predominantly over posterior electrodes. Most individuals with PMS demonstrate positive overall phase bias while most typically developing individuals demonstrate negative overall phase bias. Among individuals with PMS, strength of alpha-gamma phase-amplitude coupling was associated with Sameness, Ritualistic, and Compulsive behaviors as measured by the Repetitive Behavior Scales-Revised (Beta = 0.545, p = 0.011). Conclusions Increased phase bias suggests potential circuit-level mechanisms underlying phenotype in PMS, offering opportunities for back-translation of findings into animal models and targeting in clinical trials.

Spatiotemporal features of β-γ phase-amplitude coupling in Parkinson’s disease derived from scalp EEG

Brain ◽  
2020 ◽  
Author(s):  
Ruxue Gong ◽  
Mirko Wegscheider ◽  
Christoph Mühlberg ◽  
Richard Gast ◽  
Christopher Fricke ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Prefrontal Cortex ◽  
Somatosensory Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Primary Motor Cortex ◽  
Rating Scale ◽  
Depth Analysis ◽  
Dorsolateral Prefrontal ◽  
Phase Amplitude

Abstract Abnormal phase-amplitude coupling between β and broadband-γ activities has been identified in recordings from the cortex or scalp of patients with Parkinson’s disease. While enhanced phase-amplitude coupling has been proposed as a biomarker of Parkinson’s disease, the neuronal mechanisms underlying the abnormal coupling and its relationship to motor impairments in Parkinson’s disease remain unclear. To address these issues, we performed an in-depth analysis of high-density EEG recordings at rest in 19 patients with Parkinson’s disease and 20 age- and sex-matched healthy control subjects. EEG signals were projected onto the individual cortical surfaces using source reconstruction techniques and separated into spatiotemporal components using independent component analysis. Compared to healthy controls, phase-amplitude coupling of Parkinson’s disease patients was enhanced in dorsolateral prefrontal cortex, premotor cortex, primary motor cortex and somatosensory cortex, the difference being statistically significant in the hemisphere contralateral to the clinically more affected side. β and γ signals involved in generating abnormal phase-amplitude coupling were not strictly phase-phase coupled, ruling out that phase-amplitude coupling merely reflects the abnormal activity of a single oscillator in a recurrent network. We found important differences for couplings between the β and γ signals from identical components as opposed to those from different components (originating from distinct spatial locations). While both couplings were abnormally enhanced in patients, only the latter were correlated with clinical motor severity as indexed by part III of the Movement Disorder Society Unified Parkinson’s Disease Rating Scale. Correlations with parkinsonian motor symptoms of such inter-component couplings were found in premotor, primary motor and somatosensory cortex, but not in dorsolateral prefrontal cortex, suggesting motor domain specificity. The topography of phase-amplitude coupling demonstrated profound differences in patients compared to controls. These findings suggest, first, that enhanced phase-amplitude coupling in Parkinson’s disease patients originates from the coupling between distinct neural networks in several brain regions involved in motor control. Because these regions included the somatosensory cortex, abnormal phase-amplitude coupling is not exclusively tied to the hyperdirect tract connecting cortical regions monosynaptically with the subthalamic nucleus. Second, only the coupling between β and γ signals from different components appears to have pathophysiological significance, suggesting that therapeutic approaches breaking the abnormal lateral coupling between neuronal circuits may be more promising than targeting phase-amplitude coupling per se.

Reduced alpha-gamma phase amplitude coupling over right parietal cortex is associated with implicit visuomotor sequence learning

NeuroImage ◽  
2016 ◽  
Vol 141 ◽  
pp. 60-70 ◽  
Author(s):  
Elinor Tzvi ◽  
Rolf Verleger ◽  
Thomas F. Münte ◽  
Ulrike M. Krämer
Keyword(s):  
Parietal Cortex ◽  
Sequence Learning ◽  
Gamma Phase ◽  
Phase Amplitude

scholarly journals Lack of evidence for cross-frequency phase-phase coupling between theta and gamma oscillations in the hippocampus

2016 ◽  
Author(s):  
Robson Scheffer-Teixeira ◽  
Adriano BL Tort
Keyword(s):  
Phase Locking ◽  
Gamma Oscillations ◽  
Actual Data ◽  
Gamma Phase ◽  
Phase Coupling ◽  
Neuronal Coding ◽  
Theoretical Support ◽  
Hippocampal Activity ◽  
Phase Amplitude ◽  
Phase Phase

AbstractPhase-amplitude coupling between theta and multiple gamma sub-bands hallmarks hippocampal activity and is believed to take part in information routing. More recently, theta and gamma oscillations were also reported to exhibit reliable phase-phase coupling, or n:m phase-locking. The existence of n:m phase-locking suggests an important mechanism of neuronal coding that has long received theoretical support. However, here we show that n:m phase-locking (1) is much lower than previously reported, (2) highly depends on epoch length, (3) does not statistically differ from chance (when employing proper surrogate methods), and that (4) filtered white noise has similar n:m scores as actual data. Moreover, (5) the diagonal stripes in theta-gamma phase-phase histograms of actual data can be explained by theta harmonics. These results point to lack of theta-gamma phase-phase coupling in the hippocampus, and suggest that studies investigating n:m phase-locking should rely on appropriate statistical controls, otherwise they could easily fall into analysis pitfalls.

Alpha-gamma phase amplitude coupling subserves information transfer during perceptual sequence learning

2018 ◽  
Vol 149 ◽  
pp. 107-117 ◽  
Author(s):  
Elinor Tzvi ◽  
Leon J. Bauhaus ◽  
Till U. Kessler ◽  
Matthias Liebrand ◽  
Malte Wöstmann ◽  
...  
Keyword(s):  
Sequence Learning ◽  
Information Transfer ◽  
Gamma Phase ◽  
Phase Amplitude

scholarly journals Theta–gamma coordination between anterior cingulate and prefrontal cortex indexes correct attention shifts

2015 ◽  
Vol 112 (27) ◽  
pp. 8457-8462 ◽  
Author(s):  
Benjamin Voloh ◽  
Taufik A. Valiante ◽  
Stefan Everling ◽  
Thilo Womelsdorf
Keyword(s):  
Prefrontal Cortex ◽  
High Frequency ◽  
Low Frequency ◽  
Irrelevant Information ◽  
Anterior Cingulate ◽  
Gamma Activity ◽  
Phase Reset ◽  
Amplitude Correlation ◽  
Phase Amplitude ◽  
Attention Shifts

Anterior cingulate and lateral prefrontal cortex (ACC/PFC) are believed to coordinate activity to flexibly prioritize the processing of goal-relevant over irrelevant information. This between-area coordination may be realized by common low-frequency excitability changes synchronizing segregated high-frequency activations. We tested this coordination hypothesis by recording in macaque ACC/PFC during the covert utilization of attention cues. We found robust increases of 5–10 Hz (theta) to 35–55 Hz (gamma) phase–amplitude correlation between ACC and PFC during successful attention shifts but not before errors. Cortical sites providing theta phases (i) showed a prominent cue-induced phase reset, (ii) were more likely in ACC than PFC, and (iii) hosted neurons with burst firing events that synchronized to distant gamma activity. These findings suggest that interareal theta–gamma correlations could follow mechanistically from a cue-triggered reactivation of rule memory that synchronizes theta across ACC/PFC.

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