scholarly journals Activated Microglia Induce Bone Marrow Mesenchymal Stem Cells to Produce Glial Cell-Derived Neurotrophic Factor and Protect Neurons Against Oxygen-Glucose Deprivation Injury

2016 ◽  
Vol 10 ◽  
Author(s):  
Bingke Lv ◽  
Feng Li ◽  
Jie Fang ◽  
Limin Xu ◽  
Chengmei Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Glial Cell ◽  
Neurotrophic Factor ◽  
Glucose Deprivation ◽  
Oxygen Glucose Deprivation ◽  
Activated Microglia ◽  
Marrow Mesenchymal Stem Cells

scholarly journals Effects of neuritin on the migration, senescence and proliferation of human bone marrow mesenchymal stem cells

2015 ◽  
Vol 20 (3) ◽  
Author(s):  
Xuhui Wang ◽  
Chunyan Liu ◽  
Fen Xu ◽  
Lijuan Cui ◽  
Siwei Tan ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
Cell Migration ◽  
Cell Lines ◽  
Neurotrophic Factor ◽  
Theoretical Basis ◽  
Comprehensive Evaluation ◽  
Marrow Mesenchymal Stem Cells

AbstractNeuritin is a neurotrophic factor associated with neuroplasticity. Most studies on neuritin focus on the nervous system; however, there has been no comprehensive evaluation of neuritin in non-neuronal cells. In this study, we screened 11 cell lines and found that neuritin was not expressed in bone marrowderived mesenchymal stem cells (BMSCs). Neuritin-expressing BMSCs were obtained by transfection. In the neuritin-expressing BMSC model, we observed significantly greater cell migration and improved anti-senescence protection, in addition to reduced proliferation and viability. In conclusion, neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells. This study provides a theoretical basis for understanding the function of neuritin.

In vitro effect of prolactin on the osteogenic potential of bone marrow mesenchymal stem cells of rats

2013 ◽  
Author(s):  
Melo Ocarino Natalia de ◽  
Silvia Silva Santos ◽  
Lorena Rocha ◽  
Juneo Freitas ◽  
Reis Amanda Maria Sena ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Osteogenic Potential ◽  
Marrow Mesenchymal Stem Cells ◽  
Vitro Effect
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