scholarly journals Altered Resting-State Functional Activity in Medication-Naive Patients With First-Episode Major Depression Disorder vs. Healthy Control: A Quantitative Meta-Analysis

2019 ◽  
Vol 13 ◽  
Author(s):  
Xiaoyue Ma ◽  
Jia Liu ◽  
Taiyuan Liu ◽  
Lun Ma ◽  
Wenhui Wang ◽  
...  
Keyword(s):  
Major Depression ◽  
Resting State ◽  
Functional Activity ◽  
Meta Analysis ◽  
First Episode ◽  
Major Depression Disorder ◽  
Healthy Control ◽  
Depression Disorder

scholarly journals Potential biomarkers of major depression diagnosis and chronicity

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257251
Author(s):  
Ana Cecília de Menezes Galvão ◽  
Raíssa Nobrega Almeida ◽  
Geovan Menezes de Sousa Júnior ◽  
Mário André Leocadio-Miguel ◽  
Fernanda Palhano-Fontes ◽  
...  
Keyword(s):  
Major Depression ◽  
Rating Scale ◽  
Serum Cortisol ◽  
First Episode ◽  
Major Depression Disorder ◽  
Reactive Protein ◽  
Mature Brain ◽  
Healthy Control ◽  
Depression Disorder ◽  
Potential Use

Background Molecular biomarkers are promising tools to be routinely used in clinical psychiatry. Among psychiatric diseases, major depression disorder (MDD) has gotten attention due to its growing prevalence and morbidity. Methods We tested some peripheral molecular parameters such as serum mature Brain-Derived Neurotrophic Factor (mBDNF), plasma C-Reactive Protein (CRP), serum cortisol (SC), and the salivary Cortisol Awakening Response (CAR), as well as the Pittsburgh sleep quality inventory (PSQI), as part of a multibiomarker panel for potential use in MDD diagnosis and evaluation of disease’s chronicity using regression models, and ROC curve. Results For diagnosis model, two groups were analyzed: patients in the first episode of major depression (MD: n = 30) and a healthy control (CG: n = 32). None of those diagnosis models tested had greater power than Hamilton Depression Rating Scale-6. For MDD chronicity, a group of patients with treatment-resistant major depression (TRD: n = 28) was tested across the MD group. The best chronicity model (p < 0.05) that discriminated between MD and TRD included four parameters, namely PSQI, CAR, SC, and mBDNF (AUC ROC = 0.99), with 96% of sensitivity and 93% of specificity. Conclusion These results indicate that changes in specific biomarkers (CAR, SC, mBDNF and PSQI) have potential on the evaluation of MDD chronicity, but not for its diagnosis. Therefore, these findings can contribute for further studies aiming the development of a stronger model to be commercially available and used in psychiatry clinical practice.

scholarly journals Antidepressants for major depression disorder in older people: a network meta-analysis

2019 ◽  
Author(s):  
Lindsay Robertson ◽  
Federico Bertolini ◽  
Nicholas Meader ◽  
Simon JC Davies ◽  
Corrado Barbui ◽  
...  
Keyword(s):  
Major Depression ◽  
Older People ◽  
Meta Analysis ◽  
Major Depression Disorder ◽  
Depression Disorder

Sub-regional hippocampal volumes in first-episode drug-naïve major depression disorder

2021 ◽  
pp. 136178
Author(s):  
Mu-N Liu ◽  
Jakobus Gerick Pantouw ◽  
Kai-Chun Yang ◽  
Li-Yu Hu ◽  
Ying-Jay Liou ◽  
...  
Keyword(s):  
Major Depression ◽  
First Episode ◽  
Major Depression Disorder ◽  
Drug Naïve ◽  
Depression Disorder

scholarly journals Depressive symptoms and neurotrophin levels in ostomy patients

2018 ◽  
Vol 67 (3) ◽  
pp. 166-173
Author(s):  
Daniela Vicente Bavaresco ◽  
Mágada Tessmann Schwalm ◽  
Luciano Kurtz Jornada ◽  
Luiz Felipe Andrade Quadros ◽  
Bruna Simon ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Major Depression ◽  
Peripheral Blood ◽  
Healthy Controls ◽  
Major Depression Disorder ◽  
Significant Difference ◽  
Healthy Control ◽  
Axis I ◽  
Cortisol Levels ◽  
Depression Disorder

ABSTRACT Objective: The aim of the present study was to investigate the depressive symptoms and changes in neurotrophins (BDNF, NGF, NT-3), and cortisol levels in serum of peripheral blood from ostomy patients compared to healthy control group. Methods: We evaluated ostomy (n = 29) and healthy control (n = 30) patients. The neurotrophin (BDNF, NGF, NT-3), and cortisol levels were assessed by ELISA in serum of peripheral blood. Depressive symptoms were defined based on the Hamilton Depression Rating Scale (HDRS), and major depression disorder was based on clinical interviews and was confirmed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I). Results: The results showed a significant decrease in BDNF levels and, a significant increase in NT-3 levels in serum of peripheral blood from ostomy patients when compared to healthy controls. The levels of NGF and cortisol showed no significant differences between groups. The depressive symptom evaluations by HDRS demonstrated a significant increase in ostomy patients when compared to healthy controls. The major depression disorder diagnosis by SCID-I showed no significant difference between groups. Conclusion: Our results suggest ostomy triggers significant depressive symptoms and alterations in neurotrophins levels in serum of peripheral blood samples collected from these patients.

scholarly journals The Altered Triple Networks Interaction in Depression under Resting State Based on Graph Theory

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Hongna Zheng ◽  
Lele Xu ◽  
Fufang Xie ◽  
Xiaojuan Guo ◽  
Jiacai Zhang ◽  
...  
Keyword(s):  
Graph Theory ◽  
Network Model ◽  
Resting State ◽  
Neural Mechanism ◽  
Anterior Insula ◽  
Major Depression Disorder ◽  
Common Framework ◽  
Healthy Control ◽  
Connectivity Degree ◽  
Depression Disorder

The triple network model (Menon, 2011) has been proposed, which helps with finding a common framework for understanding the dysfunction in core neurocognitive network across multiple disorders. The alteration of the triple networks in the major depression disorder (MDD) is not clear. In our study, the altered interaction of the triple networks, which include default model network (DMN), central executive network (CEN), and salience network (SN), was examined in the MDD by graph theory method. The results showed that the connectivity degree of right anterior insula (rAI) significantly increased in MDD compared with healthy control (HC), and the connectivity degree between DMN and CEN significantly decreased in MDD. These results not only supported the proposal of the triple network model, but also prompted us to understand the dysfunction of neural mechanism in MDD.

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