scholarly journals Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes

2017 ◽  
Vol 11 ◽  
Author(s):  
Andrea de Bartolomeis ◽  
Elisabetta F. Buonaguro ◽  
Gianmarco Latte ◽  
Rodolfo Rossi ◽  
Federica Marmo ◽  
...  
Keyword(s):  
Immediate Early Genes ◽  
Immediate Early ◽  
Drug Induced ◽  
Early Genes ◽  
Brain Changes

The role of immediate early genes in the stabilization of long-term potentiation

1991 ◽  
Vol 5 (2-4) ◽  
pp. 297-314 ◽  
Author(s):  
Wickliffe C. Abraham ◽  
Michael Dragunow ◽  
Warren P. Tate
Keyword(s):  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation

Immediate-early genes, kindling and long-term potentiation

1989 ◽  
Vol 13 (4) ◽  
pp. 301-313 ◽  
Author(s):  
M. Dragunow ◽  
R.W. Currie ◽  
R.L.M. Faull ◽  
H.A. Robertson ◽  
K. Jansen
Keyword(s):  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation

Injury-induced long-term expression of immediate early genes in the rat superior cervical ganglion

Neuroreport ◽  
1993 ◽  
Vol 4 (1) ◽  
pp. 37-40 ◽  
Author(s):  
Jari Koistinaho ◽  
Markku Pelto-Huikko ◽  
Stephen M. Sagar ◽  
Åke Dagerlind ◽  
Reina Roivainen ◽  
...  
Keyword(s):  
Superior Cervical Ganglion ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Early Genes ◽  
Cervical Ganglion

scholarly journals A negative correlation between the induction of long-term potentiation and activation of immediate early genes

1991 ◽  
Vol 11 (1) ◽  
pp. 89-91 ◽  
Author(s):  
Steven S. Schreiber ◽  
Stephen Maren ◽  
Georges Tocco ◽  
Tracey Jo Shors ◽  
Richard F. Thompson
Keyword(s):  
Negative Correlation ◽  
Immediate Early Genes ◽  
Long Term Potentiation ◽  
Immediate Early ◽  
Early Genes ◽  
Term Potentiation

Noradrenergic influences on the cerebellar cortex: Effects on vestibular reflexes under basic and adaptive conditions

1998 ◽  
Vol 119 (1) ◽  
pp. 93-105 ◽  
Author(s):  
Ottavio Pompeiano
Keyword(s):  
Purkinje Cells ◽  
Immediate Early Genes ◽  
Visual Signals ◽  
Immediate Early ◽  
Vestibular Reflexes ◽  
Opposite Result ◽  
Early Genes ◽  
Ocular Reflex ◽  
Vestibulo Ocular Reflex

Experiments performed either in decerebrate cats or in intact rabbits have shown that functional inactivation of the cerebellar anterior vermis or the flocculus decreased the basic gain of the vestibulospinal or the vestibulo-ocular reflex, respectively. These findings were attributed to the fact that a proportion of the vermal or floccular Purkinje cells, which are inhibitory in function, discharge out of phase with respect to the vestibulospinal or the vestibulo-ocular neurons during sinusoidal animal rotation, thus exerting a facilitatory influence on the gain of the vestibular reflexes. Intravermal injection of a β-noradrenergic agonist slightly increased the gain of the vestibulospinal reflex, whereas the opposite result was obtained after injection of β-antagonists. Similarly, intrafloccular injection of a β-noradrenergic agonist slightly facilitated the gain of the vestibulo-ocular reflex in darkness (but not in light), whereas a small decrease of the reflex occurred after injection of a β-antagonist. It was postulated that the noradrenergic system acts on Purkinje cells by enhancing their amplitude of modulation to a given labyrinth signal, thus increasing the basic gain of the vestibular reflexes. The Purkinje cells of the cerebellar anterior vermis and the flocculus also exert a prominent role on the adaptation of vestibulospinal and vestibulo-ocular reflexes, respectively. In particular, intravermal or intrafloccular injection of β-noradrenergic antagonists decreased or suppressed the adaptive capacity of the vestibulospinal and vestibulo-ocular reflexes that always occurred during sustained out-of-phase neck-vestibular or visual-vestibular stimulation, whereas the opposite result was obtained after local injection of a β-noradrenergic agonist. The noradrenergic innervation of the cere-bellar cortex originates from the locus coeruleus complex, whose neurons respond to vestibular, neck, and visual signals. It was postulated that this structure acts through β-adrenoceptors to increase the expression of immediate-early genes, such as c- fos and Jun-B, in the Purkinje cells during vestibular adaptation. Induction of immediate-early genes could then represent a mechanism by which impulses elicited by sustained neck-vestibular or visuovestibular stimulation are transduced into long-term biochemical changes that are required for cerebellar long-term plasticity. (Otolaryngol Head Neck Surg 1998;119:93-105.)

scholarly journals Deletion of multiple immediate–early genes from herpes simplex virus reduces cytotoxicity and permits long-term gene expression in neurons

Gene Therapy ◽  
1998 ◽  
Vol 5 (12) ◽  
pp. 1593-1603 ◽  
Author(s):  
DM Krisky ◽  
D Wolfe ◽  
WF Goins ◽  
PC Marconi ◽  
R Ramakrishnan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Immediate Early Genes ◽  
Immediate Early ◽  
Early Genes ◽  
Simplex Virus
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