scholarly journals Long-Term Sertraline Intake Reverses the Behavioral Changes Induced by Prenatal Stress in Rats in a Sex-Dependent Way

2017 ◽  
Vol 11 ◽  
Author(s):  
Inês Pereira-Figueiredo ◽  
Orlando Castellano ◽  
Adelaida S. Riolobos ◽  
Graça Ferreira-Dias ◽  
Dolores E. López ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Behavioral Changes

Prenatal stress in rats attenuates hippocampal long-term potentiation and induces deficits in synaptic plasticity

2006 ◽  
Vol 16 ◽  
pp. S52
Author(s):  
S. Salomon ◽  
Y. Nachum-Biala ◽  
Y. Bogush ◽  
M. Lineal ◽  
H. Matzner ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Prenatal Stress ◽  
Long Term Potentiation ◽  
Term Potentiation

Hunter-Gatherer Mobility and Versatility: A Consideration of Long-Term Lithic Supply in the Midwest

2019 ◽  
Vol 85 (1) ◽  
pp. 113-131
Author(s):  
Mark F. Seeman ◽  
Amanda N. Colucci ◽  
Charles Fulk
Keyword(s):  
Social Change ◽  
North America ◽  
Behavioral Changes ◽  
Size And Shape ◽  
Historical Sequences

Hunter-gatherer societies held sway in midwestern North America for at least 11,000 years. Those at the end of this period were more complex and less mobile, and they supported larger populations than those at the beginning, but there are relatively few general conceptions as to when and how this took place. Here we examine the fit of gradual, one-way social change as it relates to the size and shape of lithic supply zones for Upper Mercer and Flint Ridge flint as well as the inflow of exotic materials. Our results show no singular cline either in the size of successive lithic supply zones or in the inflow of exotic materials. Hunter-gatherer societies can make remarkable behavioral changes through time and not necessarily in any consistent (unilineal) direction. Such differences impose more contingency—and less directionality—into particular historical sequences.

scholarly journals Deficits in motor and cognitive functions in an adult mouse model of hypoxia-ischemia induced stroke

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Li Feng ◽  
Chun-Xia Han ◽  
Shu-Yu Cao ◽  
He-Ming Zhang ◽  
Gang-Yi Wu
Keyword(s):  
Cognitive Deficits ◽  
Neuronal Loss ◽  
Behavioral Changes ◽  
Morris Water Maze Test ◽  
Functional Deficits ◽  
Stroke Research ◽  
Ipsilateral Striatum ◽  
Histological Data ◽  
The Right

AbstractIschemic strokes cause devastating brain damage and functional deficits with few treatments available. Previous studies have shown that the ischemia-hypoxia rapidly induces clinically similar thrombosis and neuronal loss, but any resulting behavioral changes are largely unknown. The goal of this study was to evaluate motor and cognitive deficits in adult HI mice. Following a previously established procedure, HI mouse models were induced by first ligating the right common carotid artery and followed by hypoxia. Histological data showed significant long-term neuronal losses and reactive glial cells in the ipsilateral striatum and hippocampus of the HI mice. Whereas the open field test and the rotarod test could not reliably distinguish between the sham and HI mice, in the tapered beam and wire-hanging tests, the HI mice showed short-term and long-term deficits, as evidenced by the increased number of foot faults and decreased hanging time respectively. In cognitive tests, the HI mice swam longer distances and needed more time to find the platform in the Morris water maze test and showed shorter freezing time in fear contextual tests after fear training. In conclusion, this study demonstrates that adult HI mice have motor and cognitive deficits and could be useful models for preclinical stroke research.

Propranolol failed to prevent severe stress-induced long-term behavioral changes in male rats

2020 ◽  
pp. 110079
Author(s):  
Mariella Bodemeier Loayza Careaga ◽  
Carlos Eduardo Neves Girardi ◽  
Deborah Suchecki
Keyword(s):  
Behavioral Changes ◽  
Male Rats ◽  
Severe Stress

New Insights into Prenatal Stress: Immediate- and Long-Term Effects on the Fetus and Their Timing

Neonatal Pain ◽  
2017 ◽  
pp. 75-85
Author(s):  
Kieran J. O’Donnell ◽  
Nadja Reissland ◽  
Vivette Glover
Keyword(s):  
Prenatal Stress ◽  
Long Term Effects

scholarly journals Explosive-driven double-blast exposure: molecular, histopathological, and behavioral consequences

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Erin K. Murphy ◽  
Diego Iacono ◽  
Hongna Pan ◽  
Jamie B. Grimes ◽  
Steven Parks ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Protein Level ◽  
Tau Phosphorylation ◽  
Behavioral Changes ◽  
Phosphorylated Tau ◽  
Total Tau ◽  
Blast Exposure ◽  
Psychiatric Sequelae ◽  
Relevant Finding

Abstract Traumatic brain injury generated by blast may induce long-term neurological and psychiatric sequelae. We aimed to identify molecular, histopathological, and behavioral changes in rats 2 weeks after explosive-driven double-blast exposure. Rats received two 30-psi (~ 207-kPa) blasts 24 h apart or were handled identically without blast. All rats were behaviorally assessed over 2 weeks. At Day 15, rats were euthanized, and brains removed. Brains were dissected into frontal cortex, hippocampus, cerebellum, and brainstem. Western blotting was performed to measure levels of total-Tau, phosphorylated-Tau (pTau), amyloid precursor protein (APP), GFAP, Iba1, αII-spectrin, and spectrin breakdown products (SBDP). Kinases and phosphatases, correlated with tau phosphorylation were also measured. Immunohistochemistry for pTau, APP, GFAP, and Iba1 was performed. pTau protein level was greater in the hippocampus, cerebellum, and brainstem and APP protein level was greater in cerebellum of blast vs control rats (p < 0.05). GFAP, Iba1, αII-spectrin, and SBDP remained unchanged. No immunohistochemical or neurobehavioral changes were observed. The dissociation between increased pTau and APP in different regions in the absence of neurobehavioral changes 2 weeks after double blast exposure is a relevant finding, consistent with human data showing that battlefield blasts might be associated with molecular changes before signs of neurological and psychiatric disorders manifest.

scholarly journals Prenatal stress causes intrauterine inflammation and serotonergic dysfunction, and long-term behavioral deficits through microbe- and CCL2-dependent mechanisms

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Helen J. Chen ◽  
Adrienne M. Antonson ◽  
Therese A. Rajasekera ◽  
Jenna M. Patterson ◽  
Michael T. Bailey ◽  
...  
Keyword(s):  
Prenatal Stress ◽  
Behavioral Deficits ◽  
Serotonergic Dysfunction
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