scholarly journals Loss of Ensemble Segregation in Dentate Gyrus, but not in Somatosensory Cortex, during Contextual Fear Memory Generalization

2016 ◽  
Vol 10 ◽  
Author(s):  
Marie Yokoyama ◽  
Naoki Matsuo
Keyword(s):  
Dentate Gyrus ◽  
Somatosensory Cortex ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory

scholarly journals Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity

2015 ◽  
Vol 9 ◽  
Author(s):  
Benjamin Chew ◽  
Jae Ryun Ryu ◽  
Teclise Ng ◽  
Dongliang Ma ◽  
Ananya Dasgupta ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Dentate Gyrus ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Gsk 3Β

scholarly journals Metabolic fingerprints of fear memory consolidation during sleep

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Iyo Koyanagi ◽  
Kazuhiro Sonomura ◽  
Toshie Naoi ◽  
Takaaki Ohnishi ◽  
Naoko Kaneko ◽  
...  
Keyword(s):  
Dentate Gyrus ◽  
Memory Consolidation ◽  
Conditioned Fear ◽  
Fear Memory ◽  
State Transitions ◽  
Contextual Fear ◽  
Memory Processing ◽  
Contextual Fear Memory ◽  
Purine Metabolites ◽  
Wake State

AbstractMetabolites underlying brain function and pathology are not as well understood as genes. Here, we applied a novel metabolomics approach to further understand the mechanisms of memory processing in sleep. As hippocampal dentate gyrus neurons are known to consolidate contextual fear memory, we analyzed real-time changes in metabolites in the dentate gyrus in different sleep–wake states in mice. Throughout the study, we consistently detected more than > 200 metabolites. Metabolite profiles changed dramactically upon sleep–wake state transitions, leading to a clear separation of phenotypes between wakefulness and sleep. By contrast, contextual fear memory consolidation induced less obvious metabolite phenotypes. However, changes in purine metabolites were observed upon both sleep–wake state transitions and contextual fear memory consolidation. Dietary supplementation of certain purine metabolites impaired correlations between conditioned fear responses before and after memory consolidation. These results point toward the importance of purine metabolism in fear memory processing during sleep.

scholarly journals Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer’s disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Christina F. de Veij Mestdagh ◽  
Jaap A. Timmerman ◽  
Frank Koopmans ◽  
Iryna Paliukhovich ◽  
Suzanne S. M. Miedema ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Memory Performance ◽  
Long Term Potentiation ◽  
Fear Memory ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Model Of Alzheimer’S Disease ◽  
Term Potentiation

AbstractHibernation induces neurodegeneration-like changes in the brain, which are completely reversed upon arousal. Hibernation-induced plasticity may therefore be of great relevance for the treatment of neurodegenerative diseases, but remains largely unexplored. Here we show that a single torpor and arousal sequence in mice does not induce dendrite retraction and synapse loss as observed in seasonal hibernators. Instead, it increases hippocampal long-term potentiation and contextual fear memory. This is accompanied by increased levels of key postsynaptic proteins and mitochondrial complex I and IV proteins, indicating mitochondrial reactivation and enhanced synaptic plasticity upon arousal. Interestingly, a single torpor and arousal sequence was also sufficient to restore contextual fear memory in an APP/PS1 mouse model of Alzheimer’s disease. Our study demonstrates that torpor in mice evokes an exceptional state of hippocampal plasticity and that naturally occurring plasticity mechanisms during torpor provide an opportunity to identify unique druggable targets for the treatment of cognitive impairment.

PKMζ maintains remote contextual fear memory by inhibiting GluA2-dependent AMPA receptor endocytosis in the prelimbic cortex

Neuroscience ◽  
2021 ◽  
Author(s):  
Lucas A. Marcondes ◽  
Jociane de C. Myskiw ◽  
Eduarda G. Nachtigall ◽  
Rodrigo F. Narvaes ◽  
Ivan Izquierdo ◽  
...  
Keyword(s):  
Ampa Receptor ◽  
Fear Memory ◽  
Prelimbic Cortex ◽  
Contextual Fear ◽  
Contextual Fear Memory ◽  
Receptor Endocytosis
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