scholarly journals N-methyl-D-aspartate receptor-mediated glutamate transmission in nucleus accumbens plays a more important role than that in dorsal striatum in cognitive flexibility

2014 ◽  
Vol 8 ◽  
Author(s):  
Xuekun Ding ◽  
Yanhua Qiao ◽  
Chengji Piao ◽  
Xigeng Zheng ◽  
Zhengkui Liu ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Cognitive Flexibility ◽  
Dorsal Striatum ◽  
Aspartate Receptor ◽  
Glutamate Transmission

scholarly journals Increased glutamate transmission onto dorsal striatum spiny projection neurons in Pink1 knockout rats

2021 ◽  
Vol 150 ◽  
pp. 105246
Author(s):  
Rose B. Creed ◽  
Rosalinda C. Roberts ◽  
Charlene B. Farmer ◽  
Lori L. McMahon ◽  
Matthew S. Goldberg
Keyword(s):  
Dorsal Striatum ◽  
Projection Neurons ◽  
Glutamate Transmission

scholarly journals Dopamine Release Neuroenergetics in Mouse Striatal Slices

2020 ◽  
Author(s):  
Msema Msackyi ◽  
Yuanxin Chen ◽  
Wangchen Tsering ◽  
Ninghan Wang ◽  
Jingyu Zhao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Nucleus Accumbens ◽  
Oxidative Phosphorylation ◽  
Neurodegenerative Disorder ◽  
Dorsal Striatum ◽  
Striatal Slices ◽  
Axonal Projections ◽  
Specific Vulnerability ◽  
Da Release

AbstractParkinson’s disease (PD) is the second most common neurodegenerative disease. Dopamine (DA) neurons in the substantia nigra par compacta with axonal projections to the dorsal striatum (dSTR) degenerate in PD while in contrast, DA neurons in the ventral tegmental area with axonal projections to the ventral striatum including the nucleus accumbens (NAcc) shell, are largely spared. To understand the pathogenesis of PD, it is important to study the neuroenergetics of DA neurons. This study aims to uncover the relative contribution of glycolysis and oxidative phosphorylation (OxPhos) to evoked DA release in the striatum. We measured evoked DA release in mouse striatal brain slices by fast-scan cyclic voltammetry every 2 minutes. Blocking OxPhos caused a greater reduction in evoked DA release in the dSTR compared to the NAcc shell, and blocking glycolysis caused a greater reduction in evoked DA release in the NAcc shell than in the dSTR. Furthermore, when glycolysis was bypassed in favor of direct OxPhos, evoked DA release in the NAcc shell was decreased by ∼50% over 40 minutes whereas evoked DA release in the dSTR was largely unaffected. These results demonstrated that the dSTR relies primarily on OxPhos for energy production to maintain evoked DA release whereas the NAcc shell relies more on glycolysis. Using two-photon imaging, we consistently found that the oxidation level of the DA terminals was higher in the dSTR than in the NAcc shell. Together, these findings partially explain the specific vulnerability of DA terminals in the dSTR to degeneration in PD.Significant statementThe neuroenergetics of dopaminergic neuron is important to understand Parkinson’s disease (PD), a neurodegenerative disorder associated with mitochondrial dysfunctions. However, the relative contributions of glycolysis and oxidative phosphorylation (OxPhos) to presynaptic energy demands in DA terminals are unclear. We addressed this question by measuring DA release in the dorsal striatum and nucleus accumbens (NAcc) shell of mouse brain using FSCV under reagents blocking different energy systems. We found that the NAcc shell relies on both glycolysis and OxPhos to maintain DA release while the dSTR relies heavily on OxPhos. We demonstrate the different neuroenergetics of DA terminals in these two brain areas, providing new fundamentally important insight into the specific vulnerability of DA terminals in the dSTR to degeneration in PD.

scholarly journals Contributions of nucleus accumbens dopamine to cognitive flexibility

2018 ◽  
Vol 50 (3) ◽  
pp. 2023-2035 ◽  
Author(s):  
Anna K. Radke ◽  
Adrina Kocharian ◽  
Dan P. Covey ◽  
David M. Lovinger ◽  
Joseph F. Cheer ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Cognitive Flexibility

scholarly journals Endogenous enkephalin is necessary for cocaine‐induced alteration in glutamate transmission within the nucleus accumbens

2020 ◽  
Author(s):  
Bethania Mongi‐Bragato ◽  
María Paula Avalos ◽  
Andrea S. Guzmán ◽  
Constanza García‐Keller ◽  
Flavia A. Bollati ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Glutamate Transmission

scholarly journals Altered levels of dopamine transporter in the frontal pole and dorsal striatum in schizophrenia

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Hirotaka Sekiguchi ◽  
Geoff Pavey ◽  
Brian Dean
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Transporter ◽  
Molecular Mechanisms ◽  
Radioligand Binding ◽  
Dorsal Striatum ◽  
Synaptic Cleft ◽  
Human Brain Tissue ◽  
Frontal Pole ◽  
Postmortem Human Brain ◽  
Mazindol Binding

AbstractThe dopamine hypothesis proposes that there is a hypodopaminergic state in the prefrontal cortex and a hyperdopaminergic state in the striatum of patients with schizophrenia. Evidence suggests the hyperdopaminergic state in the striatum is due to synaptic dopamine elevation, particularly in the dorsal striatum. However, the molecular mechanisms causing disrupted dopaminergic function in schizophrenia remains unclear. We postulated that the dopamine transporter (DAT), which regulates intra-synaptic dopamine concentrations by transporting dopamine from the synaptic cleft into the pre-synaptic neuron, could be involved in dopaminergic dysfunction in schizophrenia. Therefore, we measured levels of DAT in the cortex and striatum from patients with schizophrenia and controls using postmortem human brain tissue. Levels of desmethylimipramine-insensitive mazindol-sensitive [3H]mazindol binding to DAT were measured using in situ radioligand binding and autoradiography in gray matter from Brodmann’s area (BA) 10, BA 17, the dorsal striatum, and nucleus accumbens from 15 patients with schizophrenia and 15 controls. Levels of desmethylimipramine-insensitive mazindol-sensitive [3H]mazindol binding were significantly higher in BA 10 from patients with schizophrenia (p = 0.004) and significantly lower in the dorsal striatum (dorsal putamen p = 0.005; dorsal caudate p = 0.007) from those with the disorder. There were no differences in levels of desmethylimipramine-insensitive [3H]mazindol binding in BA 17 or nucleus accumbens. These data raise the possibility that high levels of DAT in BA 10 could be contributing to lower synaptic cortical dopamine, whereas lower levels of DAT could be contributing to a hyperdopaminergic state in the dorsal striatum.

Author response for "Endogenous enkephalin is necessary for cocaine‐induced alteration in glutamate transmission within the nucleus accumbens"

2020 ◽  
Author(s):  
Bethania Mongi‐Bragato ◽  
María Paula Avalos ◽  
Andrea S. Guzmán ◽  
Constanza García‐Keller ◽  
Flavia A. Bollati ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Author Response ◽  
Glutamate Transmission
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