scholarly journals Whole-Brain Atrophy Differences between Progressive Supranuclear Palsy and Idiopathic Parkinson’s Disease

2016 ◽  
Vol 8 ◽  
Author(s):  
Carlos Guevara ◽  
Katherina Bulatova ◽  
Gareth J. Barker ◽  
Guido Gonzalez ◽  
Nicolas A. Crossley ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progressive Supranuclear Palsy ◽  
Brain Atrophy ◽  
Idiopathic Parkinson’S Disease ◽  
Whole Brain ◽  
Idiopathic Parkinson's Disease

scholarly journals Whole-Brain Atrophy Rate in Idiopathic Parkinson’s Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
C. Guevara ◽  
K. Bulatova ◽  
G. J. Barker ◽  
G. Gonzalez ◽  
N. Crossley ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Trials ◽  
Multiple System Atrophy ◽  
Progressive Supranuclear Palsy ◽  
Brain Atrophy ◽  
Idiopathic Parkinson’S Disease ◽  
Whole Brain ◽  
Atrophy Rate ◽  
Idiopathic Parkinson's Disease

In multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), the absence of surrogate endpoints makes clinical trials long and expensive. We aim to determine annualized whole-brain atrophy rates (a-WBAR) in idiopathic Parkinson’s disease (IPD), MSA, and PSP. Ten healthy controls, 20 IPD, 12 PSP, and 8 MSA patients were studied using a volumetric MRI technique (SIENA). In controls, the a-WBAR was0.37%±0.28(CI 95% 0.17–0.57), while in IPD a-WBAR was0.54%±0.38(CI 95% 0.32–0.68). The IPD patients did not differ from the controls. In PSP, the a-WBAR was1.26%±0.51(CI 95%: 0.95–1.58). In MSA, a-WBAR was1.65%±1.12(CI 95%: 0.71–2.59). MSA did not differ from PSP. The a-WBAR in PSP and MSA were significantly higher than in the IPD group (p=0.004andp<0.001, resp.). In PSP, the use of a-WBAR required one-half of the patients needed for clinical scales to detect a 50% reduction in their progression. In MSA, one-quarter of the patients would be needed to detect the same effect. a-WBAR is a reasonable candidate to consider as a surrogate endpoint in short clinical trials using smaller sample sizes. The confidence intervals for a-WBAR may add a potential retrospective application for a-WBAR to improve the diagnostic accuracy of MSA and PSP versus IPD.

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