scholarly journals Comparative Genome Analysis and Phenotypic Characterization of Clostridium gasigenes CGAS001 Isolated From Chilled Vacuum-Packed Lamb Meat

2020 ◽  
Vol 11 ◽  
Author(s):  
Joseph Wambui ◽  
Nicole Cernela ◽  
Sabrina Corti ◽  
Roger Stephan
Keyword(s):  
Genome Analysis ◽  
Phenotypic Characterization ◽  
Comparative Genome Analysis ◽  
Comparative Genome ◽  
Lamb Meat

Phenotypic characterization and comparative genome analysis of two strains of thermophilic, anaerobic, cellulolytic-xylanolytic bacterium Herbivorax saccincola

2020 ◽  
Vol 136 ◽  
pp. 109517
Author(s):  
Shimpei Aikawa ◽  
Phakhinee Thianheng ◽  
Sirilak Baramee ◽  
Umbhorn Ungkulpasvich ◽  
Chakrit Tachaapaikoon ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Phenotypic Characterization ◽  
Comparative Genome Analysis ◽  
Comparative Genome

scholarly journals Comparative genome analysis and characterization of a MDR Klebsiella variicola

Genomics ◽  
2020 ◽  
Vol 112 (5) ◽  
pp. 3179-3190
Author(s):  
Vijaya Bharathi Srinivasan ◽  
Govindan Rajamohan
Keyword(s):  
Genome Analysis ◽  
Comparative Genome Analysis ◽  
Comparative Genome

Comparative genome analysis of monocots and dicots, toward characterization of angiosperm diversity

2004 ◽  
Vol 15 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Andrew H Paterson ◽  
John E Bowers ◽  
Brad A Chapman ◽  
Daniel G Peterson ◽  
Junkang Rong ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Comparative Genome Analysis ◽  
Comparative Genome

scholarly journals High Permissiveness for Genetic Exchanges between Enteroviruses of Species A, including Enterovirus 71, Favors Evolution through Intertypic Recombination in Madagascar

2019 ◽  
Vol 93 (6) ◽  
Author(s):  
Romain Volle ◽  
Richter Razafindratsimandresy ◽  
Marie-Line Joffret ◽  
Maël Bessaud ◽  
Sendraharimanana Rabemanantsoa ◽  
...  
Keyword(s):  
Genome Analysis ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Genetic Exchange ◽  
Neurological Manifestations ◽  
Comparative Genome Analysis ◽  
Local Circulation ◽  
Comparative Genome ◽  
Different Types

ABSTRACTHuman enteroviruses of species A (EV-A) are the leading cause of hand-foot-and-mouth disease (HFMD). EV-A71 is frequently implicated in HFMD outbreaks and can also cause severe neurological manifestations. We investigated the molecular epidemiological processes at work and the contribution of genetic recombination to the evolutionary history of EV-A in Madagascar, focusing on the recently described EV-A71 genogroup F in particular. Twenty-three EV-A isolates, collected mostly in 2011 from healthy children living in various districts of Madagascar, were characterized by whole-genome sequencing. Eight different types were identified, highlighting the local circulation and diversity of EV-A. Comparative genome analysis revealed evidence of frequent recent intra- and intertypic genetic exchanges between the noncapsid sequences of Madagascan EV-A isolates. The three EV-A71 isolates had different evolutionary histories in terms of recombination, with one isolate displaying a mosaic genome resulting from recent genetic exchanges with Madagascan coxsackieviruses A7 and possibly A5 and A10 or common ancestors. The engineering and characterization of recombinants generated from progenitors belonging to different EV-A types or EV-A71 genogroups with distantly related nonstructural sequences indicated a high level of permissiveness for intertypic genetic exchange in EV-A. This permissiveness suggests that the primary viral functions associated with the nonstructural sequences have been highly conserved through the diversification and evolution of the EV-A species. No outbreak of disease due to EV-A has yet been reported in Madagascar, but the diversity, circulation, and evolution of these viruses justify surveillance of EV-A circulation and HFMD cases to prevent possible outbreaks due to emerging strains.IMPORTANCEHuman enteroviruses of species A (EV-A), including EV-A71, are the leading cause of hand-foot-and-mouth disease (HFMD) and may also cause severe neurological manifestations. We investigated the circulation and molecular evolution of EV-A in Madagascar, focusing particularly on the recently described EV-A71 genogroup F. Eight different types, collected mostly in 2011, were identified, highlighting the local circulation and diversity of EV-A. Comparative genome analysis revealed evidence of frequent genetic exchanges between the different types of isolates. The three EV-A71 isolates had different evolutionary histories in terms of recombination. The engineering and characterization of recombinants involving progenitors belonging to different EV-A types indicated a high degree of permissiveness for genetic exchange in EV-A. No outbreak of disease due to EV-A has yet been reported in Madagascar, but the diversity, circulation, and evolution of these viruses justify the surveillance of EV-A circulation to prevent possible HFMD outbreaks due to emerging strains.

Synteny Conservation and Chromosome Rearrangements During Mammalian Evolution

Genetics ◽  
1997 ◽  
Vol 147 (1) ◽  
pp. 289-296 ◽  
Author(s):  
Jason Ehrlich ◽  
David Sankoff ◽  
Joseph H Nadeau
Keyword(s):  
Genome Analysis ◽  
Systematic Errors ◽  
Chromosome Rearrangements ◽  
Mammalian Evolution ◽  
Comparative Genome Analysis ◽  
Reciprocal Translocations ◽  
Comparative Genome ◽  
Strong Selection ◽  
Synteny Conservation

Abstract An important problem in comparative genome analysis has been defining reliable measures of synteny conservation. The published analytical measures of synteny conservation have limitations. Nonindependence of comparisons, conserved and disrupted syntenies that are as yet unidentified, and redundant rearrangements lead to systematic errors that tend to overestimate the degree of conservation. We recently derived methods to estimate the total number of conserved syntenies within the genome, counting both those that have already been described and those that remain to be discovered. With this method, we show that ~65% of the conserved syntenies have already been identified for humans and mice, that rates of synteny disruption vary ~25-fold among mammalian lineages, and that despite strong selection against reciprocal translocations, inter-chromosome rearrangements occurred approximately fourfold more often than inversions and other intra-chromosome rearrangements, at least for lineages leading to humans and mice.

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