scholarly journals Characterization of Novel Broad-Host-Range Bacteriophage DLP3 Specific to Stenotrophomonas maltophilia as a Potential Therapeutic Agent

2020 ◽  
Vol 11 ◽  
Author(s):  
Danielle L. Peters ◽  
Jaclyn G. McCutcheon ◽  
Jonathan J. Dennis
Keyword(s):  
Host Range ◽  
Stenotrophomonas Maltophilia ◽  
Therapeutic Agent ◽  
Broad Host Range ◽  
Potential Therapeutic Agent

scholarly journals Genetic Characterization of Broad-Host-Range IncQ Plasmids Harboring blaVEB-18 in Vibrio Species

2017 ◽  
Vol 61 (7) ◽  
Author(s):  
Ruichao Li ◽  
Lianwei Ye ◽  
Zhiwei Zheng ◽  
Edward Wai Chi Chan ◽  
Sheng Chen
Keyword(s):  
Host Range ◽  
Genetic Characterization ◽  
Vibrio Species ◽  
Broad Host Range ◽  
Incq Plasmids

scholarly journals Genomic and Proteomic Characterization of the Broad-Host-Range Salmonella Phage PVP-SE1: Creation of a New Phage Genus

2011 ◽  
Vol 85 (21) ◽  
pp. 11265-11273 ◽  
Author(s):  
S. B. Santos ◽  
A. M. Kropinski ◽  
P.-J. Ceyssens ◽  
H.- W. Ackermann ◽  
A. Villegas ◽  
...  
Keyword(s):  
Host Range ◽  
Broad Host Range ◽  
Salmonella Phage

Characterization of Gram-positive broad host-range plasmids carrying a thermophilic replicon

1991 ◽  
Vol 142 (4) ◽  
pp. 389-396 ◽  
Author(s):  
E De Rossi ◽  
P Brigidi ◽  
M Rossi ◽  
D Matteuzzi ◽  
G Riccardi
Keyword(s):  
Host Range ◽  
Broad Host Range ◽  
Gram Positive ◽  
Broad Host Range Plasmids

scholarly journals JD419, a Staphylococcus aureus Phage With a Unique Morphology and Broad Host Range

2021 ◽  
Vol 12 ◽  
Author(s):  
Tingting Feng ◽  
Sebastian Leptihn ◽  
Ke Dong ◽  
Belinda Loh ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Host Range ◽  
Antibiotic Resistance Genes ◽  
Multidrug Resistant ◽  
Complete Characterization ◽  
Resistant Bacteria ◽  
Broad Host Range ◽  
Gene Engineering ◽  
Mrsa Strains

Phage therapy represents a possible treatment option to cure infections caused by multidrug-resistant bacteria, including methicillin and vancomycin-resistant Staphylococcus aureus, to which most antibiotics have become ineffective. In the present study, we report the isolation and complete characterization of a novel phage named JD219 exhibiting a broad host range able to infect 61 of 138 clinical strains of S. aureus tested, which included MRSA strains as well. The phage JD419 exhibits a unique morphology with an elongated capsid and a flexible tail. To evaluate the potential of JD419 to be used as a therapeutic phage, we tested the ability of the phage particles to remain infectious after treatment exceeding physiological pH or temperature. The activity was retained at pH values of 6.0–8.0 and below 50°C. As phages can contain virulence genes, JD419’s complete genome was sequenced. The 45509 bp genome is predicted to contain 65 ORFs, none of which show homology to any known virulence or antibiotic resistance genes. Genome analysis indicates that JD419 is a temperate phage, despite observing rapid replication and lysis of host strains. Following the recent advances in synthetic biology, JD419 can be modified by gene engineering to remove prophage-related genes, preventing potential lysogeny, in order to be deployed as a therapeutic phage.

scholarly journals Isolation and characterization of novel broad host range bacteriophages of Vibrio cholerae O1 from Bengal

2018 ◽  
Vol 10 (2) ◽  
pp. 84
Author(s):  
BanwarilalL Sarkar ◽  
Sounak Sarkar ◽  
Mayukh Das ◽  
TusharSuvra Bhowmick ◽  
Hemanta Koley ◽  
...  
Keyword(s):  
Host Range ◽  
Vibrio Cholerae ◽  
Broad Host Range ◽  
Isolation And Characterization ◽  
Vibrio Cholerae O1
Sign in / Sign up

Export Citation Format

Share Document