scholarly journals Membrane-Interactive Compounds From Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence

2020 ◽  
Vol 11 ◽  
Author(s):  
Ali Tahrioui ◽  
Sergio Ortiz ◽  
Onyedikachi Cecil Azuama ◽  
Emeline Bouffartigues ◽  
Nabiha Benalia ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Pistacia Lentiscus ◽  
Membrane Interactive

scholarly journals Membrane-Interactive Compounds from Pistacia lentiscus L. Thwart Pseudomonas aeruginosa Virulence

2020 ◽  
Author(s):  
Ali Tahrioui ◽  
Sergio Ortiz ◽  
Onyedikachi Cecil Azuama ◽  
Emeline Bouffartigues ◽  
Nabiha Benalia ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Virulence Factors ◽  
Wall Stress ◽  
Host Immune System ◽  
Pistacia Lentiscus ◽  
Regulatory Pathways ◽  
Ginkgolic Acid ◽  
Host Infection ◽  
Promising Perspective ◽  
Membrane Interactive

ABSTRACTPseudomonas aeruginosa is capable to deploy a collection of virulence factors that are not only essential for host infection and persistence, but also to escape from the host immune system and to become more resistant to drug therapies. Thus, developing anti-virulence agents that may directly counteract with specific virulence factors or disturb higher regulatory pathways controlling the production of virulence armories are urgently needed. In this regard, this study reports that Pistacia lentiscus L. fruit cyclohexane extract (PLFE1) thwarts P. aeruginosa virulence by targeting mainly the pyocyanin pigment production by interfering with 4-hydroxy-2-alkylquinolines molecules production. Importantly, the anti-virulence activity of PLFE1 appears to be associated with membrane homeostasis alteration through the modulation of SigX, an extracytoplasmic function sigma factor involved in cell wall stress response. A thorough chemical analysis of PLFE1 allowed us to identify the ginkgolic acid (C17:1) and hydroginkgolic acid (C15:0) as the main bioactive membrane-interactive compounds responsible for the observed increased membrane stiffness and anti-virulence activity against P. aeruginosa. This study delivers a promising perspective for the potential future use of PLFE1 or ginkgolic acid molecules as an adjuvant therapy to fight against P. aeruginosa infections.

scholarly journals Antibacterial Activity of the Essential Oils of Pistacia lentiscus Used in Moroccan Folkloric Medicine

2011 ◽  
Vol 6 (10) ◽  
pp. 1934578X1100601 ◽  
Author(s):  
Fatima Zohra Mharti ◽  
Badiaa Lyoussi ◽  
Abdelfattah Abdellaoui
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Essential Oil ◽  
Essential Oils ◽  
Klebsiella Pneumonia ◽  
Pistacia Lentiscus ◽  
Oil Composition ◽  
Strong Activity ◽  
Middle Atlas

The essential oil of the leaves of Pistacia lentiscus, collected from the middle Atlas in Morocco, was analyzed by GC and GC–MS. Altogether 43 components in concentrations of more than 0.2% were identified representing 97.4% of the oil composition. The main constituents were germanicol (12.8%), thunbergol (8.8%), himachalene (7.4%), trans-squalene (6.7%), terpinyl propionate (6.7%), 3,3-dimenthol (6.2%) and cadina-1.4-diene (5.1%). The oils showed strong activity against Klebsiella pneumonia, but no activity against Pseudomonas aeruginosa.

Pistacia lentiscus L. Fruit Thwart Pseudomonas aeruginosa Virulence Through Membrane Fluidity Alteration

2020 ◽  
Author(s):  
Sylvie Michel ◽  
Raphaël Grougnet ◽  
Smain CHEMAT ◽  
Azuama Onyedikachi Cecil ◽  
Sylvie Chevalier ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Membrane Fluidity ◽  
Pistacia Lentiscus

Effekt von Acetylcystein auf die Pseudomonas aeruginosa-induzierte Mukusexpression

Pneumologie ◽  
2010 ◽  
Vol 64 (01) ◽  
Author(s):  
L Sprenger ◽  
T Goldmann ◽  
E Vollmer ◽  
B Wollenberg ◽  
P Zabel ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa

Effekt von Dexamethason auf die Pseudomonas aeruginosa-induzierte Mukusexpression in humaner Atemwegsmukosa

Pneumologie ◽  
2010 ◽  
Vol 64 (S 03) ◽  
Author(s):  
L Spenger ◽  
T Goldmann ◽  
E Vollmer ◽  
B Wollenberg ◽  
HP Hauber ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa
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