scholarly journals Evaluation of High-Pressure Processing in Inactivation of the Hepatitis E Virus

2020 ◽  
Vol 11 ◽  
Author(s):  
Neda Nasheri ◽  
Tanushka Doctor ◽  
Angela Chen ◽  
Jennifer Harlow ◽  
Alexander Gill
Keyword(s):  
High Pressure ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
High Pressure Processing

scholarly journals Evaluation of High-Pressure Processing in Inactivation of the Hepatitis E Virus

2019 ◽  
Author(s):  
Neda Nasheri ◽  
Tanushka Doctor ◽  
Angela Chen ◽  
Jennifer Harlow ◽  
Alexander Gill
Keyword(s):  
High Pressure ◽  
Hepatitis E Virus ◽  
Foodborne Pathogen ◽  
Hepatitis E ◽  
Developed Countries ◽  
High Pressure Processing ◽  
Pathogen Inactivation ◽  
Genotype 3 ◽  
Similar Treatment ◽  
Log Reduction

Hepatitis E virus (HEV) causes acute hepatitis with approximately 20 million cases per year globally. While HEV is endemic in certain regions of Asia, Africa and South America, it is considered an emerging foodborne pathogen in developed countries. Based on genetic diversity, HEV is classified into different genotypes, with genotype 3 (HEV-3) being most prevalent in Europe and North America. The transmission of HEV-3 has been shown to be zoonotic and mainly associated with the consumption of raw or undercooked pork products. Herein, we investigated the efficacy of high-pressure processing (HPP) in the inactivation of HEV-3 using a cell culture system. HPP has been indicated as a promising nonthermal pathogen inactivation strategy for treatment of certain high-risk food commodities, without any noticeable changes in their nature. For this purpose, we treated HEV-3 in media as well as in artificially inoculated pork pâté, with different conditions of HPP: 400 MPa for 1 and 5 minutes, as well as 600 MPa for 1 and 5 minutes, at ambient temperature. In general, we observed approximately a 2-log reduction in HEV load by HPP treatments in media; however, similar treatment in the pork pâté resulted in a much lower reduction in viral load. Therefore, the efficacy of HPP treatment in the inactivation of HEV-3 is matrix-dependent.

Hepatitis E Virus in LeberBiopsien von Patienten mit akuter Hepatitis unbekannter Ätiologie

2011 ◽  
Vol 49 (01) ◽  
Author(s):  
C Dorloff ◽  
J Hemberger ◽  
M Odenthal ◽  
H Holzmann ◽  
S Aberle ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E

Severe course of Hepatitis E Virus infection in a patient with pre-existing autoimmune liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
S Schlosser ◽  
J Pflaum ◽  
K Weigand ◽  
JJ Wenzel ◽  
W Jilg ◽  
...  
Keyword(s):  
Liver Disease ◽  
Virus Infection ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Autoimmune Liver Disease

Transfusion-transmitted hepatitis E virus infections: a risk for immunosuppressed patients

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
D Westhölter ◽  
J Hartl ◽  
J Hiller ◽  
U Denzer ◽  
S Peine ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Virus Infections ◽  
Immunosuppressed Patients

Hepatitis E Virus: No Evidence of Parenteral Transmission in Finland

1995 ◽  
Vol 74 (05) ◽  
pp. 1385-1386 ◽  
Author(s):  
Pirkko Pohjanpelto ◽  
Freja Ebeling ◽  
Vesa Rasi ◽  
Hartmut Hampl
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Parenteral Transmission

Infection of Pigs with Avian Hepatitis E Virus (HEV)

2005 ◽  
Author(s):  
C. Kasorndorkbua ◽  
P. J. Thomas ◽  
Patrick G. Halbur ◽  
D. K. Guenette ◽  
F. F. Huang ◽  
...  
Keyword(s):  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Avian Hepatitis E Virus
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