scholarly journals Current Affairs of Microbial Genome-Wide Association Studies: Approaches, Bottlenecks and Analytical Pitfalls

2020 ◽  
Vol 10 ◽  
Author(s):  
James Emmanuel San ◽  
Shakuntala Baichoo ◽  
Aquillah Kanzi ◽  
Yumna Moosa ◽  
Richard Lessells ◽  
...  
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Microbial Genome ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Current Affairs

scholarly journals Microbial Genome-Wide Association Studies: Lessons from Human GWAS

2016 ◽  
Author(s):  
Robert A. Power ◽  
Julian Parkhill ◽  
Tulio de Oliveira
Keyword(s):  
Disease Transmission ◽  
Drug Targets ◽  
Association Studies ◽  
Genome Wide Association ◽  
Microbial Genome ◽  
Genome Wide Association Studies ◽  
Genome Wide ◽  
Disease Aetiology ◽  
Number Of Microorganisms ◽  
Potential Drug Targets

AbstractThe reduced costs of sequencing have led to the availability of whole genome sequences for a large number of microorganisms, enabling the application of microbial genome wide association studies (GWAS). Given the successes of human GWAS in understanding disease aetiology and identifying potential drug targets, microbial GWAS is likely to further advance our understanding of infectious diseases. By building on the success of GWAS, microbial GWAS have the potential to rapidly provide important insights into pressing global health problems, such as antibiotic resistance and disease transmission. In this review, we outline the methodologies of GWAS, the state of the field of microbial GWAS today, and how lessons from GWAS can direct the future of the field.

scholarly journals Microbial genome-wide association studies: lessons from human GWAS

2016 ◽  
Vol 18 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Robert A. Power ◽  
Julian Parkhill ◽  
Tulio de Oliveira
Keyword(s):  
Association Studies ◽  
Genome Wide Association ◽  
Microbial Genome ◽  
Genome Wide Association Studies ◽  
Genome Wide
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