scholarly journals Niflumic Acid Reverses Airway Mucus Excess and Improves Survival in the Rat Model of Steroid-Induced Pneumocystis Pneumonia

2019 ◽  
Vol 10 ◽  
Author(s):  
Francisco J. Pérez ◽  
Pablo A. Iturra ◽  
Carolina A. Ponce ◽  
Fabien Magne ◽  
Víctor Garcia-Angulo ◽  
...  
Keyword(s):  
Rat Model ◽  
Pneumocystis Pneumonia ◽  
Niflumic Acid ◽  
Airway Mucus

scholarly journals Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR

2020 ◽  
Vol 202 (9) ◽  
pp. 1271-1282 ◽  
Author(s):  
Susan E. Birket ◽  
Joy M. Davis ◽  
Courtney M. Fernandez-Petty ◽  
Alexander G. Henderson ◽  
Ashley M. Oden ◽  
...  
Keyword(s):  
Rat Model ◽  
Airway Mucus

scholarly journals New Rat Model of Pneumocystis Pneumonia Induced by Anti-CD4+ T-Lymphocyte Antibodies

2003 ◽  
Vol 71 (11) ◽  
pp. 6292-6297 ◽  
Author(s):  
Timothy D. Thullen ◽  
Alan D. Ashbaugh ◽  
Kieran R. Daly ◽  
Michael J. Linke ◽  
Paul E. Steele ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
T Cell ◽  
Host Defense ◽  
T Lymphocyte ◽  
Rat Model ◽  
Cell Function ◽  
Opportunistic Infections ◽  
Pneumocystis Pneumonia ◽  
Cell Number ◽  
Limited Attention

ABSTRACT The CD4+ T lymphocyte plays a central role in host defense against Pneumocystis pneumonia but has received only limited attention in rats. CD4+ T-cell-depleting (OX-38) and nondepleting (W3/25) monoclonal antibodies, which recognize an identical or adjacent epitope, were administered for up to 14 weeks to Lewis rats that had been exposed to Pneumocystis. While OX-38 produced a greater decrease in circulating CD4+ cells than W3/25, both antibody treatments resulted in similar effects on the health of the rats and the levels of Pneumocystis pneumonia, which were milder than those found with corticosteroids. W3/25 also did not enhance the severity of Pneumocystis pneumonia achieved with corticosteroids alone. We conclude that CD4+ cell function is more important than CD4+ cell number in host defense against Pneumocystis in the rat and that this new model permits study of opportunistic infections in the rat without the confounding effects of corticosteroids.

1045: Pioglitazone Ameliorates Penile Corpora Veno-Occlusive Dysfunction (CVOD) in a Rat Model of Type 2 Diabetes

2005 ◽  
Vol 173 (4S) ◽  
pp. 283-284
Author(s):  
Istvan Kovanecz ◽  
Monica G. Ferrini ◽  
Hugo H. Davila ◽  
Jacob Rajfer ◽  
Nestor F. Gonzalez-Cadavid
Keyword(s):  
Type 2 Diabetes ◽  
Rat Model

V1341: The Rat Model of Cavernous Nerve Injury: Practical Aspects

2005 ◽  
Vol 173 (4S) ◽  
pp. 364-365
Author(s):  
John F. Donohue ◽  
Michael Mullerad ◽  
Philip S. Li ◽  
Peter T. Scardino ◽  
John P. Mulhall
Keyword(s):  
Nerve Injury ◽  
Rat Model ◽  
Cavernous Nerve ◽  
Cavernous Nerve Injury

1441: Experimental Success of Biodegradable Conduit Graft for Regeneration and Reconnection of Transected Cavernous Nerves in a Rat Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 379-380
Author(s):  
Shinichi Hisasue ◽  
Ryuichi Kato ◽  
Yoshikazu Sato ◽  
Takahiro Suetomi ◽  
Atsushi Takahashi ◽  
...  
Keyword(s):  
Rat Model ◽  
Cavernous Nerves

1713: Effect of Botulinum Toxin on Overactive Bladder Contractions Induced by Intra Vesical ATP and Capsaicin in the RAT Model

2004 ◽  
Vol 171 (4S) ◽  
pp. 453-453
Author(s):  
Humphrey O. Atiemo ◽  
Jacob Wynes ◽  
James Chuo ◽  
Lisa Nipkow ◽  
Geoffrey N. Sklar ◽  
...  
Keyword(s):  
Botulinum Toxin ◽  
Overactive Bladder ◽  
Rat Model
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