scholarly journals In vitro Susceptibility and Evaluation of Techniques for Understanding the Mode of Action of a Promising Non-antibiotic Citrus Fruit Extract Against Several Pathogens

2019 ◽  
Vol 10 ◽  
Author(s):  
Pedro J. G. de Nova ◽  
Ana Carvajal ◽  
Miguel Prieto ◽  
Pedro Rubio
Keyword(s):  
Mode Of Action ◽  
Citrus Fruit ◽  
Fruit Extract ◽  
In Vitro Susceptibility

In vitro susceptibility of Brachyspira hyodysenteriae to a commercial citrus fruit extract

2017 ◽  
Vol 115 ◽  
pp. 318-324 ◽  
Author(s):  
Pedro J.G. de Nova ◽  
Ana Carvajal ◽  
Miguel Prieto ◽  
Pedro Rubio
Keyword(s):  
Citrus Fruit ◽  
Fruit Extract ◽  
In Vitro Susceptibility ◽  
Brachyspira Hyodysenteriae

Antibacterial activity and mode of action of a commercial citrus fruit extract

2013 ◽  
Vol 115 (1) ◽  
pp. 50-60 ◽  
Author(s):  
A. Álvarez-Ordóñez ◽  
A. Carvajal ◽  
H. Arguello ◽  
F.J. Martínez-Lobo ◽  
G. Naharro ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Mode Of Action ◽  
Citrus Fruit ◽  
Fruit Extract

scholarly journals A Citrus Fruit Extract High in Polyphenols Beneficially Modulates the Gut Microbiota of Healthy Human Volunteers in a Validated In Vitro Model of the Colon

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3915
Author(s):  
Mônica Maurer Sost ◽  
Sanne Ahles ◽  
Jessica Verhoeven ◽  
Sanne Verbruggen ◽  
Yala Stevens ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
In Vitro Model ◽  
Citrus Fruit ◽  
Short Chain Fatty Acids ◽  
Overweight And Obesity ◽  
Fruit Extract ◽  
Healthy Human ◽  
Human Volunteers ◽  
Vitro Model

The effect of a Citrus Fruit Extract high in the polyphenols hesperidin and naringin (CFE) on modulation of the composition and activity of the gut microbiota was tested in a validated, dynamic in vitro model of the colon (TIM-2). CFE was provided at two doses (250 and 350 mg/day) for 3 days. CFE led to a dose-dependent increase in Roseburia, Eubacterium ramulus, and Bacteroides eggerthii. There was a shift in production of short-chain fatty acids, where acetate production increased on CFE, while butyrate decreased. In overweight and obesity, acetate has been shown to increase fat oxidation when produced in the distal gut, and stimulate secretion of appetite-suppressive neuropeptides. Thus, the data in the in vitro model point towards mechanisms underlying the effects of the polyphenols in CFE with respect to modulation of the gut microbiota, both in composition and activity. These results should be confirmed in a clinical trial.

Evaluation of antioxidant activity of Artocarpus hirsutus methanolic fruit extract: An in vitro study

2012 ◽  
Vol 2 (12) ◽  
pp. 58-59
Author(s):  
suvarna M N Vinay ◽  
◽  
Ramesh B S Ramesh B S ◽  
Venkatachalapathy R Venkatachalapathy R ◽  
Makari Hanumantappa K ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
In Vitro Study ◽  
Vitro Study ◽  
Fruit Extract

Role of 4-O Galloylchlorogenic Acid in Lung Cancer- An Insilico Approach

2017 ◽  
Vol 9 (5) ◽  
Author(s):  
Jaynthy C. ◽  
N. Premjanu ◽  
Abhinav Srivastava
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
In Silico ◽  
Computational Study ◽  
Regulation Mechanism ◽  
Down Regulation ◽  
Fruit Extract ◽  
In Vitro Techniques ◽  
Discovery Studio

Cancer is a major disease with millions of patients diagnosed each year with high mortality around the world. Various studies are still going on to study the further mechanisms and pathways of the cancer cell proliferation. Fucosylation is one of the most important oligosaccharide modifications involved in cancer and inflammation. In cancer development increased core fucosylation by FUT8 play an important role in cell proliferation. Down regulation of FUT8 expression may help cure lung cancer. Therefore the computational study based on the down regulation mechanism of FUT8 was mechanised. Sapota fruit extract, containing 4-Ogalloylchlorogenic acid was used as the inhibitor against FUT-8 as target and docking was performed using in-silico tool, Accelrys Discovery Studio. There were several conformations of the docked result, and conformation 1 showed 80% dock score between the ligand and the target. Further the amino acids of the inhibitor involved in docking were studied using another tool, Ligplot. Thus, in-silico analysis based on drug designing parameters shows that the fruit extract can be studied further using in-vitro techniques to know its pharmacokinetics.

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