scholarly journals Histopathological Features and Composition of Gut Microbiota in Rhesus Monkey of Alcoholic Liver Disease

2019 ◽  
Vol 10 ◽  
Author(s):  
Hong Wang ◽  
Yaping Yan ◽  
Xiaoyan Yi ◽  
Yanchao Duan ◽  
Junfeng Wang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Rhesus Monkey ◽  
Alcoholic Liver Disease ◽  
Histopathological Features

Gut Microbiota and Alcoholic Liver Disease

2016 ◽  
Vol 11 (3) ◽  
pp. 213-219 ◽  
Author(s):  
Emidio Scarpellini ◽  
Forlino Mariana ◽  
Lupo Marinella ◽  
Rasetti Carlo ◽  
Fava Giammarco ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease

scholarly journals Modulation of gut microbiota mediates berberine‐induced expansion of immuno‐suppressive cells to against alcoholic liver disease

2020 ◽  
Vol 10 (4) ◽  
Author(s):  
Sha Li ◽  
Ning Wang ◽  
Hor‐Yue Tan ◽  
Fan Chueng ◽  
Zhang‐Jin Zhang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease

Regulatory effect of volatile compounds in fermented alcoholic beverages on gut microbiota and serum metabolism in mouse model

2021 ◽  
Author(s):  
Mei Ji ◽  
Cheng Fang ◽  
Wei Jia ◽  
Hai Du ◽  
Yan Xu
Keyword(s):  
Risk Factor ◽  
Liver Disease ◽  
Mouse Model ◽  
Gut Microbiota ◽  
Volatile Compounds ◽  
Alcoholic Liver Disease ◽  
Alcoholic Beverages ◽  
Regulatory Effect ◽  
Main Risk Factor

Ethanol (EtOH) is the main risk factor for alcoholic liver disease. However, fermented alcoholic beverages contain not only ethanol but also various volatile compounds. Currently, effects of volatile compounds in...

Changes in gut microbiota, nutritional and liver parameters in patients with alcoholic liver disease

2021 ◽  
Vol 46 ◽  
pp. S653
Author(s):  
O.S. Dizdar ◽  
V. Lazarevic ◽  
S. Leo ◽  
V.L. Karsegard ◽  
J. Schrenzel ◽  
...  
Keyword(s):  
Liver Disease ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease ◽  
Liver Parameters

scholarly journals Streptococcus, the Predominant Bacterium to Predict the Severity of Liver Injury in Alcoholic Liver Disease

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaodan Zhong ◽  
Ping Cui ◽  
Junjun Jiang ◽  
Chuanyi Ning ◽  
Bingyu Liang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Injury ◽  
Gut Microbiota ◽  
Alcoholic Liver Disease ◽  
Early Stage ◽  
Characteristic Curve ◽  
Hepatic Function ◽  
Rrna Gene ◽  
Alcoholic Fatty Liver ◽  
Predominant Bacterium

BackgroundNew evidence implies that the imbalance of gut microbiota is associated with the progression of alcoholic liver disease (ALD) and that the composition of gut microbiota is altered in ALD patients. However, the predominant bacterium in patients involved in the progress of ALD has not been identified. The purpose of this study is to investigate the predominant bacterium in the early and end-stages of ALD as well as the relationship between the bacterium and the degree of liver injury.MethodsWe enrolled 21 alcoholic fatty liver (AFL) patients, 17 alcoholic liver cirrhosis (ALC) patients and 27 healthy controls, and sequenced the 16S rRNA gene of their fecal microbiota. The gut microbiota composition and its relationship with the indicators of clinical hepatic function were assessed using canonical correspondence analysis (CCA), spearman correlation heatmap and multivariate association with linear (MaAsLin) Models.ResultsThe composition and structure of gut microbiota changed greatly in different stages of ALD, and the degree of disorder was aggravated with the progression of ALD, even in the early stage. Moreover, the relative abundance of Streptococcus was highly enriched only in patients with ALC (P <0.001), and positively correlated with AST level (P = 0.029). The abundance of Streptococcus distinguished the liver injury of ALC patients from the controls with an area under the receiver-operating characteristic curve (AUC) of 0.877 (P < 0.001).ConclusionsThese findings indicate that the imbalance of gut microbiota exists at the early and end-stages of ALD, and the degree of disorder is aggravated with the progression of ALD. Streptococcus, as the predominant bacterium, may be a microbiological marker to evaluate the severity of liver injury in ALD patients.

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