scholarly journals Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise

2019 ◽  
Vol 10 ◽  
Author(s):  
Wanbo Tai ◽  
Denis Voronin ◽  
Jiawei Chen ◽  
Weili Bao ◽  
Debra A. Kessler ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Tissue Tropism ◽  
Fetal Demise ◽  
Zika Virus Infection ◽  
Pregnant Mice

scholarly journals Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Diogo M. Magnani ◽  
Thomas F. Rogers ◽  
Nicholas J. Maness ◽  
Nathan D. Grubaugh ◽  
Nathan Beutler ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Antibody Therapy ◽  
Fetal Demise ◽  
Zika Virus Infection

scholarly journals Transfer of convalescent serum to pregnant mice prevents Zika virus infection and microcephaly in offspring

Cell Research ◽  
2016 ◽  
Vol 27 (1) ◽  
pp. 158-160 ◽  
Author(s):  
Shuo Wang ◽  
Shuai Hong ◽  
Yong-Qiang Deng ◽  
Qing Ye ◽  
Ling-Zhai Zhao ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Zika Virus Infection ◽  
Pregnant Mice

scholarly journals Pregnancy alters innate immune responses to Zika virus infection in the genital tract

2019 ◽  
Author(s):  
Kelsey E. Lesteberg ◽  
Dana S. Fader ◽  
J. David Beckham
Keyword(s):  
Virus Infection ◽  
Immune Responses ◽  
Zika Virus ◽  
Immune Cell ◽  
Innate Immune ◽  
Innate Immune Cells ◽  
Innate Immune Responses ◽  
Zikv Infection ◽  
Zika Virus Infection ◽  
Pregnant Mice

AbstractRecent outbreaks of Zika virus (ZIKV) have been associated with birth defects, including microcephaly and neurological impairment. However, the mechanisms which confer increased susceptibility to ZIKV during pregnancy remain unclear. We hypothesized that poor outcomes from ZIKV infection during pregnancy are due in part to pregnancy-induced alteration of innate immune cell frequencies and cytokine expression. To examine the impact of pregnancy on innate immune responses, we inoculated pregnant and non-pregnant female C57BL/6 mice with 5×105 FFU of ZIKV intravaginally. Innate immune cell frequencies and cytokine expression were measured by flow cytometry at day 3 post infection. Compared to non-pregnant mice, pregnant mice exhibited higher frequencies of uterine macrophages (CD68+) and tolerogenic dendritic cells (CD11c+ CD103+ and CD11c+ CD11b+). Additionally, ZIKV-infected pregnant mice had lower frequencies of CD45+ IL-12+ and CD11b+ IL-12+ cells in the uterus and spleen. These data show that pregnancy results in an altered innate immune response to ZIKV infection in the genital tract of mice and that pregnancy-associated immune modulation may play an important role in the severity of acute ZIKV infection.ImportancePregnant females longer duration that viremia following infection with Zika virus but the mechanism of this is not established. Innate immune cellular responses are important for controlling virus infection and are important for development and maintenance of pregnancy. Thus, the acute immune response to Zika virus during pregnancy may be altered so that the pregnancy can be maintained. To examine this interaction, we utilized a mouse model of Zika virus infection during pregnancy using intravaginal inoculation. We found that following Zika virus infection, pregnant mice exhibited increased expression of tolerant or non-inflammatory dendritic cells. Additionally, we found that pregnant mice have significantly depressed ability to secrete the cytokine IL-12 from innate immune cells in the uterus and the spleen while maintaining MHCII expression. These findings show that pregnancy-induced changes in the innate immune cells are biased towards tolerance and can result in decreased antigen-dependent stimulation of immune responses.

scholarly journals Zika virus infection in immunocompetent pregnant mice causes fetal damage and placental pathology in the absence of fetal infection

2018 ◽  
Vol 14 (4) ◽  
pp. e1006994 ◽  
Author(s):  
Frank M. Szaba ◽  
Michael Tighe ◽  
Lawrence W. Kummer ◽  
Kathleen G. Lanzer ◽  
Jerrold M. Ward ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Placental Pathology ◽  
Zika Virus Infection ◽  
Fetal Infection ◽  
Pregnant Mice

scholarly journals Zika Virus Infection and Stillbirths: A Case of Hydrops Fetalis, Hydranencephaly and Fetal Demise

2016 ◽  
Vol 10 (2) ◽  
pp. e0004517 ◽  
Author(s):  
Manoel Sarno ◽  
Gielson A. Sacramento ◽  
Ricardo Khouri ◽  
Mateus S. do Rosário ◽  
Federico Costa ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Hydrops Fetalis ◽  
Fetal Demise ◽  
Zika Virus Infection

scholarly journals Zika Virus Infection during Pregnancy in Mice Causes Placental Damage and Fetal Demise

Cell ◽  
2016 ◽  
Vol 165 (5) ◽  
pp. 1081-1091 ◽  
Author(s):  
Jonathan J. Miner ◽  
Bin Cao ◽  
Jennifer Govero ◽  
Amber M. Smith ◽  
Estefania Fernandez ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Fetal Demise ◽  
Zika Virus Infection

scholarly journals A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Yufeng Yu ◽  
Yong-Qiang Deng ◽  
Peng Zou ◽  
Qian Wang ◽  
Yanyan Dai ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Zika Virus Infection ◽  
Pregnant Mice
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