scholarly journals Rutin and Its Combination With Inulin Attenuate Gut Dysbiosis, the Inflammatory Status and Endoplasmic Reticulum Stress in Paneth Cells of Obese Mice Induced by High-Fat Diet

2018 ◽  
Vol 9 ◽  
Author(s):  
Xiulan Guo ◽  
Renyong Tang ◽  
Shiyong Yang ◽  
Yurong Lu ◽  
Jing Luo ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Paneth Cells ◽  
Obese Mice ◽  
High Fat ◽  
Gut Dysbiosis ◽  
Inflammatory Status

scholarly journals Supplementation of quinoa regulates glycolipid metabolism and endoplasmic reticulum stress in the high-fat diet-induced female obese mice

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Tian An ◽  
Jia-Xian Liu ◽  
Xiu-yan Yang ◽  
Bo-han Lv ◽  
Yan-xiang Wu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Blood Glucose ◽  
Endoplasmic Reticulum Stress ◽  
Er Stress ◽  
High Fat Diet ◽  
Liver Tissue ◽  
Obese Mice ◽  
High Fat ◽  
Glycolipid Metabolism

Abstract Objective To explore the effects of the quinoa diet on glycolipid metabolism and endoplasmic reticulum (ER) stress in an obese mouse model. Methods Six-week-old C57BL/6J female mice have received a high-fat diet (HFD) to induce obesity and subsequently were treated with a quinoa diet for 12 weeks. During this period, fasting blood glucose, body fat and insulin resistance were measured regularly. At the end of the experiment, mouse serum and liver tissue were collected. The differences in glucose and lipid metabolism were analyzed, and liver tissue pathological morphology, liver endoplasmic reticulum stress-related mRNA and protein levels, and serum oxidative stress levels were measured. Results Quinoa diet could significantly reduce the level of blood glucose, triglyceride, cholesterol, low-density lipoprotein, improve glucose tolerance, as well as improve histological changes of liver tissues in obese mice (P < 0.05 or < 0.01). Besides, quinoa could improve oxidative stress indicators such as GSH, and MDA (P < 0.05 or < 0.01). Furthermore, quinoa can down-regulate mRNA expression of ER stress markers eIF2α, GRP78, and CHOP in the liver of obese mice (P < 0.05 or < 0.01). Conclusions Quinoa supplementation can improve glycolipid metabolism, regulate ER stress, and alleviate obesity in HFD-induced mice.

Su2125 High Fat Diet Induced Activation of Autophagy in Paneth Cells Is Responsible for Gut Dysbiosis and Intestinal Inflammation in Rats

2013 ◽  
Vol 144 (5) ◽  
pp. S-564
Author(s):  
Shi-Yi Zhou ◽  
Pornchai Leelasinjaroen ◽  
Merritt Gillilland ◽  
Hui Zhou ◽  
Chung Owyang
Keyword(s):  
High Fat Diet ◽  
Intestinal Inflammation ◽  
Paneth Cells ◽  
High Fat ◽  
Gut Dysbiosis

scholarly journals Inhibition of endoplasmic reticulum stress prevents high‐fat diet mediated atrial fibrosis and fibrillation

2020 ◽  
Vol 24 (23) ◽  
pp. 13660-13668
Author(s):  
Yan Zhang ◽  
Shuwen Yang ◽  
Jing Fu ◽  
Annan Liu ◽  
Deping Liu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
High Fat Diet ◽  
Atrial Fibrosis ◽  
High Fat

scholarly journals Palmitic Acid–Rich High-Fat Diet Exacerbates Experimental Pulmonary Fibrosis by Modulating Endoplasmic Reticulum Stress

2019 ◽  
Vol 61 (6) ◽  
pp. 737-746 ◽  
Author(s):  
Sarah G. Chu ◽  
Julian A. Villalba ◽  
Xiaoliang Liang ◽  
Kevin Xiong ◽  
Konstantin Tsoyi ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Pulmonary Fibrosis ◽  
Endoplasmic Reticulum Stress ◽  
Palmitic Acid ◽  
High Fat Diet ◽  
High Fat
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