scholarly journals SbbR/SbbA, an Important ArpA/AfsA-Like System, Regulates Milbemycin Production in Streptomyces bingchenggensis

2018 ◽  
Vol 9 ◽  
Author(s):  
Hairong He ◽  
Lan Ye ◽  
Chuang Li ◽  
Haiyan Wang ◽  
Xiaowei Guo ◽  
...  
Keyword(s):  
Streptomyces Bingchenggensis

Characterization and analysis of an industrial strain of Streptomyces bingchenggensis by genome sequencing and gene microarray

Genome ◽  
2013 ◽  
Vol 56 (11) ◽  
pp. 677-689 ◽  
Author(s):  
Xiang-Jing Wang ◽  
Bo Zhang ◽  
Yi-Jun Yan ◽  
Jing An ◽  
Ji Zhang ◽  
...  
Keyword(s):  
Natural Products ◽  
Gene Cluster ◽  
Crop Protection ◽  
Gc Content ◽  
Gene Clusters ◽  
High Expression ◽  
Expression Level ◽  
Transcriptional Analysis ◽  
Streptomyces Bingchenggensis ◽  
High Expression Level

Streptomyces bingchenggensis is a soil bacterium that produces milbemycins, a family of macrolide antibiotics that are commercially important in crop protection and veterinary medicine. In addition, S. bingchenggensis produces many other natural products including the polyether nanchangmycin and novel cyclic pentapeptides. To identify the gene clusters involved in the biosynthesis of these compounds, and better clarify the biochemical pathways of these gene clusters, the whole genome of S. bingchenggensis was sequenced, and the transcriptome profile was subsequently investigated by microarray. In comparison with other sequenced genomes in Streptomyces, S. bingchenggensis has the largest linear chromosome consisting of 11 936 683 base pairs (bp), with an average GC content of 70.8%. The 10 023 predicted protein-coding sequences include at least 47 gene clusters correlated with the biosynthesis of known or predicted secondary metabolites. Transcriptional analysis demonstrated an extremely high expression level of the milbemycin gene cluster during the entire growth period and a moderately high expression level of the nanchangmycin gene cluster during the initial hours that subsequently decreased. However, other gene clusters appear to be silent. The genome-wide analysis of the secondary metabolite gene clusters in S. bingchenggensis, coupled with transcriptional analysis, will facilitate the rational development of high milbemycins-producing strains as well as the discovery of new natural products.

Improved milbemycin production by engineering two Cytochromes P450 in Streptomyces bingchenggensis

2020 ◽  
Vol 104 (7) ◽  
pp. 2935-2946 ◽  
Author(s):  
Haiyan Wang ◽  
Xu Cheng ◽  
Yuqing Liu ◽  
Shanshan Li ◽  
Yanyan Zhang ◽  
...  
Keyword(s):  
Cytochromes P450 ◽  
Streptomyces Bingchenggensis

Two new milbemycin derivatives from a genetically engineered strain Streptomyces bingchenggensis

2020 ◽  
pp. 1-6
Author(s):  
Jian-Song Li ◽  
Huan Qi ◽  
Shao-Yong Zhang ◽  
Wen-Sheng Xiang ◽  
Li-Qin Zhang ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Streptomyces Bingchenggensis ◽  
Engineered Strain

ChemInform Abstract: Further New Milbemycin Antibiotics from Streptomyces bingchenggensis.

ChemInform ◽  
2008 ◽  
Vol 39 (13) ◽  
Author(s):  
Wen-Sheng Xiang ◽  
Ji-Dong Wang ◽  
Xiang-Jing Wang ◽  
Ji Zhang ◽  
Ze Wang
Keyword(s):  
Streptomyces Bingchenggensis

ChemInform Abstract: New Seco-Milbemycins from Streptomyces bingchenggensis: Fermentation, Isolation amd Structure Elucidation.

ChemInform ◽  
2008 ◽  
Vol 39 (31) ◽  
Author(s):  
Wen-Sheng Xiang ◽  
Ji-Dong Wang ◽  
Hong-Mei Fan ◽  
Xiang-Jing Wang ◽  
Ji Zhang
Keyword(s):  
Structure Elucidation ◽  
Streptomyces Bingchenggensis

scholarly journals New milbemycins from mutant Streptomyces bingchenggensis X-4

2011 ◽  
Vol 64 (11) ◽  
pp. 753-756 ◽  
Author(s):  
Bao-Xin Zhang ◽  
Hui Zhang ◽  
Xiang-Jing Wang ◽  
Ji-Dong Wang ◽  
Chong-Xi Liu ◽  
...  
Keyword(s):  
Streptomyces Bingchenggensis

New milbemycin metabolites from the genetically engineered strain Streptomyces bingchenggensis BCJ60

2016 ◽  
Vol 31 (7) ◽  
pp. 780-784 ◽  
Author(s):  
Jian-Song Li ◽  
Min-Na Du ◽  
Hui Zhang ◽  
Ji Zhang ◽  
Shao-Yong Zhang ◽  
...  
Keyword(s):  
Genetically Engineered ◽  
Streptomyces Bingchenggensis ◽  
Engineered Strain

scholarly journals Mining and fine-tuning sugar uptake system for titer improvement of milbemycins in Streptomyces bingchenggensis

2020 ◽  
Vol 5 (3) ◽  
pp. 214-221
Author(s):  
Pinjiao Jin ◽  
Shanshan Li ◽  
Yanyan Zhang ◽  
Liyang Chu ◽  
Hairong He ◽  
...  
Keyword(s):  
Fine Tuning ◽  
Sugar Uptake ◽  
Uptake System ◽  
Streptomyces Bingchenggensis
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