scholarly journals Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1

2018 ◽  
Vol 9 ◽  
Author(s):  
Celestino Velásquez ◽  
Yutaka Amako ◽  
Alexis Harold ◽  
Tuna Toptan ◽  
Yuan Chang ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Merkel Cell Polyomavirus ◽  
Carcinoma Cell Line ◽  
Merkel Cell

Establishment and characterization of a merkel cell carcinoma cell line

1993 ◽  
Vol 6 (1) ◽  
pp. 65
Author(s):  
Tadashi Karashima ◽  
Hiroshi Hachisuka ◽  
Yoichiro Sasai
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Merkel Cell

Establishment and characterization of a merkel cell carcinoma cell line

1993 ◽  
Vol 6 (1) ◽  
pp. 65
Author(s):  
Hikaru Eto ◽  
Kohzoh Yonemoto ◽  
Takao Fujimura ◽  
Yuko Hamada ◽  
Shigeo Nishiyama ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Merkel Cell

scholarly journals Activation of the MAP Kinase Pathway Induces Apoptosis in the Merkel Cell Carcinoma Cell Line UISO

2007 ◽  
Vol 127 (9) ◽  
pp. 2116-2122 ◽  
Author(s):  
Roland Houben ◽  
Sonja Ortmann ◽  
David Schrama ◽  
Marco J. Herold ◽  
Ingolf Berberich ◽  
...  
Keyword(s):  
Map Kinase ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Merkel Cell Carcinoma ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Merkel Cell ◽  
Map Kinase Pathway ◽  
Kinase Pathway

scholarly journals Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Kashif Rasheed ◽  
Baldur Sveinbjørnsson ◽  
Ugo Moens
Keyword(s):  
High Risk ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Merkel Cell Carcinoma ◽  
Transcriptional Activity ◽  
Carcinoma Cell ◽  
Merkel Cell ◽  
Late Promoter ◽  
Tumor Viruses ◽  
E6 And E7

Abstract Background Approximately 15% of human cancers are attributed to viruses. Numerous studies have shown that high-risk human polyomaviruses (HR-HPV) and Merkel cell polyomavirus (MCPyV) are two human tumor viruses associated with anogenetal and oropharyngeal cancers, and with Merkel cell carcinoma, respectively. MCPyV has been found in HR-HPV positive anogenetal and oropharyngeal tumors, suggesting that MCPyV can act as a co-factor in HR-HPV induced oncogenesis. This prompted us to investigate whether the oncoproteins large T-antigen (LT) and small antigen (sT) of MCPyV could affect the transcriptional activity HPV16 and HPV18 and vice versa whether HPV16 and HPV18 E6 and E7 oncoproteins affected the expression of MCPyV LT and sT. Reciprocal stimulation of these viral oncoproteinscould enhance the oncogenic processes triggered by these tumor viruses. Methods Transient co-transfection studies using a luciferase reporter plasmid with the long control region of HPV16 or HPV18, or the early or late promoter of MCPyV and expression plasmids for LT and sT, or E6 and E7, respectively were performed in the HPV-negative cervical cancer cell line C33A, in the keratinocyte cell line HaCaT, and in the oral squamous cell carcinoma cell line HSC-3. Transfections were also performed with deletion mutants of all these promoters and with mutants of all four oncoproteins. Finally, the effect of E6 and E7 on LT and sT expression in the MCPyV-positive Merkel cell carcinoma cell line WaGa and the effect of LT and sT on the expression of E6 and E7 was monitored by Western blotting. Results LT and sT stimulated the transcriptional activity of the HPV16 and HPV18 LCR and v.v. E6 and E7 potentiated the MCPyV early and late promoter in all cell lines. Induction by E6 and E7 was p53- and pRb-independent, and transactivation by LT did not require DNA binding, nuclear localization and HSC70/pRb interaction, whereas sT stimulated the HPV16/18 LCR activity in a PP2A- and DnaJ-independent manner. Conclusions These results indicate that the co-infection of MCPyV may act as a co-factor in the initiation and/or progression of HPV-induced cancers.

Establishment and characterization of a clear cell carcinoma cell line, designated NOCC, derived from human ovary

Human Cell ◽  
2016 ◽  
Vol 29 (4) ◽  
pp. 188-196 ◽  
Author(s):  
Akihiro Ohyama ◽  
Junko Toyomura ◽  
Toshiaki Tachibana ◽  
Seiji Isonishi ◽  
Haruka Takahashi ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Clear Cell ◽  
Carcinoma Cell ◽  
Clear Cell Carcinoma ◽  
Carcinoma Cell Line ◽  
Human Ovary

Characterization of a Renal Cell Carcinoma Cell Line Suitable as a Target for Immunological Studies in Vitro and in the NU/NU Mouse

1985 ◽  
Vol 134 (6) ◽  
pp. 1271-1275 ◽  
Author(s):  
Martin H. Goldrosen ◽  
Robert Huben ◽  
Glenn A. Miller ◽  
David A. Lewis ◽  
Hisako Ochi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Renal Cell ◽  
Carcinoma Cell ◽  
Carcinoma Cell Line ◽  
Renal Cell Carcinoma Cell
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