scholarly journals High-Fat Diet Induces Dysbiosis of Gastric Microbiota Prior to Gut Microbiota in Association With Metabolic Disorders in Mice

2018 ◽  
Vol 9 ◽  
Author(s):  
Cong He ◽  
Dandan Cheng ◽  
Chao Peng ◽  
Yanshu Li ◽  
Yin Zhu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
High Fat ◽  
Gastric Microbiota

DHA-enriched phospholipids from large yellow croaker roe regulate lipid metabolic disorders and gut microbiota imbalance on SD rats with a high-fat diet

2021 ◽  
Author(s):  
Xiaodan Lu ◽  
Rongbin Zhong ◽  
Ling Hu ◽  
Luyao Huang ◽  
Lijiao Chen ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Docosahexaenoic Acid ◽  
Gut Microbiota ◽  
Polyunsaturated Fatty Acids ◽  
High Fat Diet ◽  
Nutritional Value ◽  
Metabolic Disorders ◽  
Large Yellow Croaker ◽  
High Fat ◽  
Sd Rats

Abstract Large yellow croaker roe phospholipids (LYCRPLs) has great nutritional value because of containing rich docosahexaenoic acid (DHA), which is a kind of n-3 polyunsaturated fatty acids (n-3 PUFAs). In...

Ethanol extract of Ganoderma lucidum ameliorates lipid metabolic disorders and modulates the gut microbiota composition in high-fat diet fed rats

2018 ◽  
Vol 9 (6) ◽  
pp. 3419-3431 ◽  
Author(s):  
Wei-Ling Guo ◽  
Yu-Yang Pan ◽  
Lu Li ◽  
Tian-Tian Li ◽  
Bin Liu ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Ganoderma Lucidum ◽  
Metabolic Disorders ◽  
Ethanol Extract ◽  
Microbiota Composition ◽  
High Fat ◽  
Gut Microbiota Composition ◽  
Mrna Expression Levels

Ethanol extract from Ganoderma lucidum (GL95), enriched with triterpenoids, has the potential to ameliorate lipid metabolic disorders, in part through modulating specific gut microbiota and regulating the mRNA expression levels of the genes involved in lipid and cholesterol.

Effects of three different mannans on obesity and gut microbiota of high-fat diet-fed C57BL/6J mice

2021 ◽  
Author(s):  
Yajian Song ◽  
Huitao Shen ◽  
Tingting Liu ◽  
Bingju Pan ◽  
Sanduni De Alwis ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Guar Gum ◽  
Konjac Glucomannan ◽  
Locust Bean Gum ◽  
High Fat ◽  
Locust Bean

To compare the effects of three mannans, Konjac glucomannan (KGM), guar gum (GG) and locust bean gum (LBG), on obesity and obesity-related metabolic disorders in high-fat diet-fed (HFD-fed) mice, and...

Monascus yellow, red and orange pigments from red yeast rice ameliorate lipid metabolic disorders and gut microbiota dysbiosis in Wistar rats fed on a high-fat diet

2019 ◽  
Vol 10 (2) ◽  
pp. 1073-1084 ◽  
Author(s):  
Wenbin Zhou ◽  
Rui Guo ◽  
Weiling Guo ◽  
Jiali Hong ◽  
Lu Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Mrna Expression ◽  
High Fat Diet ◽  
Wistar Rats ◽  
Metabolic Disorders ◽  
Cholesterol Metabolism ◽  
Red Yeast Rice ◽  
High Fat ◽  
Red Yeast ◽  
Gut Microbiota Dysbiosis

Monascus yellow, red and orange pigments modulate specific gut microbial phylotypes and regulating mRNA expression involved in glucose, lipid and cholesterol metabolism.

scholarly journals Purple-leaf tea (Camellia sinensis L.) ameliorates high-fat diet induced obesity and metabolic disorder through the modulation of the gut microbiota in mice

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yu-Chun Lin ◽  
Hsu-Feng Lu ◽  
Jui-Chieh Chen ◽  
Hsiu-Chen Huang ◽  
Yu-Hsin Chen ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Gut Microbiota ◽  
Camellia Sinensis ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Metabolic Diseases ◽  
Normal Diet ◽  
High Fat ◽  
Hepatic Diseases ◽  
Purple Leaf

Abstract Background Obesity and its associated diseases have become a major world-wide health problem. Purple-leaf Tea (Camellia sinensis L.) (PLT), that is rich of anthocyanins, has been shown to have preventive effects on obesity and metabolic disorders. The intestinal microbiota has been shown to contribute to inflammation, obesity, and several metabolic disorders. However, whether PLT consumption could prevent obesity and diet-induced metabolic diseases by modulating the gut microbiota, is not clearly understood. Methods In this study, six-week-old male C57BL/6 J mice were fed a normal diet (ND) or a high fat diet (HFD) without or with PLT for 10 weeks. Results PLT modulated the gut microbiota in mice and alleviated the symptoms of HFD-induced metabolic disorders, such as insulin resistance, adipocyte hypertrophy, and hepatic steatosis. PLT increased the diversity of the microbiota and the ratio of Firmicutes to Bacteroidetes. f_Barnesiellaceae, g_Barnesiella, f_Ruminococcaceae, and f_Lachnospiraceae were discriminating faecal bacterial communities of the PLT mice that differed from the HFD mice. Conclusions These data indicate that PLT altered the microbial contents of the gut and prevented microbial dysbiosis in the host, and consequently is involved in the modulation of susceptibility to insulin resistance, hepatic diseases, and obesity that are linked to an HFD.

Sarcodon aspratus polysaccharides ameliorated obesity-induced metabolic disorders and modulated gut microbiota dysbiosis in mice fed a high-fat diet

2020 ◽  
Vol 11 (3) ◽  
pp. 2588-2602 ◽  
Author(s):  
Juan Chen ◽  
Jiaojiao Liu ◽  
Chenchen Yan ◽  
Chan Zhang ◽  
Wenjuan Pan ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
Fruit Body ◽  
High Fat ◽  
Potential Health ◽  
Gut Microbiota Dysbiosis

The polysaccharides isolated from the fruit body of S. aspratus (SATPs) might be a potential health supplement or prebiotic in the prevention of obesity and associated metabolic disorders.

scholarly journals Correlations between α-Linolenic Acid-Improved Multitissue Homeostasis and Gut Microbiota in Mice Fed a High-Fat Diet

mSystems ◽  
2020 ◽  
Vol 5 (6) ◽  
Author(s):  
Xiaoyu Gao ◽  
Songlin Chang ◽  
Shuangfeng Liu ◽  
Lei Peng ◽  
Jing Xie ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Linolenic Acid ◽  
High Fat Diet ◽  
Metabolic Disorders ◽  
The Body ◽  
Metabolic Phenotype ◽  
High Fat ◽  
Strong Negative Correlation ◽  
Correlation Networks ◽  
Metabolic Endotoxemia

ABSTRACT Previous studies have shown that α-linolenic acid (ALA) has a significant regulatory effect on related disorders induced by high-fat diets (HFDs), but little is known regarding the correlation between the gut microbiota and disease-related multitissue homeostasis. We systematically investigated the effects of ALA on the body composition, glucose homeostasis, hyperlipidemia, metabolic endotoxemia and systemic inflammation, white adipose tissue (WAT) homeostasis, liver homeostasis, intestinal homeostasis, and gut microbiota of mice fed an HFD (HFD mice). We found that ALA improved HFD-induced multitissue metabolic disorders and gut microbiota disorders to various degrees. Importantly, we established a complex but clear network between the gut microbiota and host parameters. Several specific differential bacteria were significantly associated with improved host parameters. Rikenellaceae_RC9_gut_group and Parasutterella were positively correlated with HFD-induced “harmful indicators” and negatively correlated with “beneficial indicators.” Intriguingly, Bilophila showed a strong negative correlation with HFD-induced multitissue metabolic disorders and a significant positive correlation with most beneficial indicators, which is different from its previous characterization as a “potentially harmful genus.” Turicibacter might be the key beneficial bacterium for ALA-improved metabolic endotoxemia, while Blautia might play an important role in ALA-improved gut barrier integrity and anti-inflammatory effects. The results suggested that the gut microbiota, especially some specific bacteria, played an important role in the process of ALA-improved multitissue homeostasis in HFD mice, and different bacteria might have different divisions of regulation. IMPORTANCE Insufficient intake of n-3 polyunsaturated fatty acids is an important issue in modern Western-style diets. A large amount of evidence now suggests that a balanced intestinal microecology is considered an important part of health. Our results show that α-linolenic acid administration significantly improved the host metabolic phenotype and gut microbiota of mice fed a high-fat diet, and there was a correlation between the improved gut microbiota and metabolic phenotype. Some specific bacteria may play a unique regulatory role. Here, we have established correlation networks between gut microbiota and multitissue homeostasis, which may provide a new basis for further elucidating the relationship between the gut microbiota and host metabolism.

scholarly journals SUN-643 Potential Contributions of Gut Microbiota-Liver Axis to the Transgenerational Metabolic Reprogramming of Maternal Exercise

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Liyuan Zhou ◽  
Xinhua Xiao ◽  
Qian Zhang ◽  
Ming Li ◽  
Miao Yu
Keyword(s):  
Fatty Acid ◽  
Gut Microbiota ◽  
High Fat Diet ◽  
Early Life ◽  
Metabolic Disorders ◽  
Male Offspring ◽  
Metabolic Reprogramming ◽  
Adult Offspring ◽  
High Fat ◽  
Maternal Exercise

Abstract Background: Early-life overnutrition programs increased risks of metabolic disorders in adulthood. Regular exercise is widely accepted to be an effective measure to maintain metabolic health. However, the transgenerational effects of maternal exercise and the specific mechanism are largely unclear. Aims: Our objective was to investigate whether maternal exercise could alleviate the metabolic disturbances induced by early-life overnutrition in both dams and offspring and to explore the role of gut microbiota-liver axis in mediating the transgenerational metabolic reprogramming. Methods: C57BL/6 females were randomly divided into three groups 3 weeks before mating and during pregnancy: the control group, high-fat group, and high-fat with exercise group (voluntary wheel running training). They received their original diets during lactation. The male offspring had ad libitum access to chow diet from weaning to 24 weeks of age. Glucose tolerance test and serum biochemical parameters were detected. The cecal contents from dams at weaning and 8-week and 24 week of offspring were collected for 16s rDNA sequencing. Hepatic HE staining and transcriptome were performed in adult offspring. Results: The results showed that perinatal high-fat diet resulted in significant glucose intolerance, insulin resistance and lipid profiles disorders in both dams and offspring. Maternal exercise markedly improved insulin sensitivity in dams and metabolic disorders in offspring from young into adulthood, especially the hepatic steatosis. The decrease in harmful bacteria and the persistent enrichment of short chain fatty acid producers from mothers to adult offspring, particularly the genus Odoribacter, were all associated with improvement in metabolism by maternal exercise. In addition, maternal exercise significant upregulated FGF21 and genes involved in the fatty acid oxidation and TCA cycle in adult offspring, which were down-regulated by perinatal high-fat diet and were significantly correlated with the altered microbial species. Conclusion: Overall, maternal exercise could significantly mitigate the detrimental effects of perinatal high-fat diet on metabolism in both dams and male offspring. The continuous alterations in gut microbiota and reprogramming hepatic metabolism might be critical factors in deciphering the transgenerational metabolic benefits of maternal exercise, which provides some novel evidence and targets for combating the metabolic diseases.

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