scholarly journals A Perspective on the Potential Zoonotic Role of Streptococcus agalactiae: Searching for a Missing Link in Alternative Transmission Routes

2018 ◽  
Vol 9 ◽  
Author(s):  
Ana C. N. Botelho ◽  
Ana F. M. Ferreira ◽  
Sergio E. L. Fracalanzza ◽  
Lucia M. Teixeira ◽  
Tatiana C. A. Pinto
Keyword(s):  
Streptococcus Agalactiae ◽  
Missing Link

Osteoporosis Entwined with Cardiovascular Disease: The Implication of Osteoprotegerin and Example of Statins

2020 ◽  
Vol 27 ◽  
Author(s):  
Maria V. Deligiorgi ◽  
Mihalis I. Panayiotidis ◽  
Gerasimos Siasos ◽  
Dimitrios T. Trafalis
Keyword(s):  
Cardiovascular Disease ◽  
Physicochemical Characteristics ◽  
Dual Role ◽  
Present Review ◽  
Vascular Cells ◽  
Molecular Fingerprint ◽  
Missing Link ◽  
Epidemiological Factors ◽  
Outstanding Issue

: Beyond being epiphenomenon of shared epidemiological factors, the integration of osteoporosis (OP) with cardiovascular disease (CVD)− termed "calcification paradox"− reflects a continuum of aberrant cardiometabolic status. The present review provides background knowledge on "calcification paradox", focusing on the endocrine aspect of vasculature orchestrated by the osteoblastic molecular fingerprint of vascular cells, acquired via imbalance among established modulators of mineralization. Osteoprotegerin (OPG)–the well-established osteoprotective cytokine−has recently been shown to exert a vessel-modifying role. Prompted by this notion, the present review interrogates OPG as the potential missing link between OP and CVD. However, so far, the confirmation of this hypothesis is hindered by the equivocal role of OPG in CVD, being both proatherosclerotic and antiatherosclerotic. Further research is needed to illuminate whether OPG could be biomarker of the "calcification paradox". Moreover, the present review brings into prominence the dual role of statins−cardioprotective and osteoprotective− as potential illustration of the integration of CVD with OP. Considering that the statins-induced modulation of OPG is central to the statins-driven osteoprotective signalling, statins could be suggested as illustration of the role of OPG in the bone/vessels crosstalk, if further studies consolidate the contribution of OPG to the cardioprotective role of statins. Another outstanding issue that merits further evaluation is the inconsistency of the osteoprotective role of statins. Further understanding of the varying bone-modifying role of statins, likely attributed to the unique profile of different classes of statins defined by distinct physicochemical characteristics, may yield tangible benefits for treating simultaneously OP and CVD.

scholarly journals Revisiting Bureaucratic Dysfunction: The Role of Bureaucracy in Democratization

2017 ◽  
Vol 32 (1) ◽  
pp. 127-147
Author(s):  
Im Tobin
Keyword(s):  
Developing Countries ◽  
Karl Marx ◽  
Max Weber ◽  
Developmental State ◽  
The Political ◽  
Missing Link

While many studies have focused on the link between economics and democracy in exploring the strategies adopted by developing countries, they have tended to overlook the role of bureaucracy in democratization. This study seeks the missing link between bureaucracy and democratization. What are the conditions necessary for bureaucracy to facilitate the democratization process of a country? This article begins by briefly reviewing the bureaucracy literature from Max Weber and Karl Marx and then argues that despite its shortcomings, bureaucracy in its Weberian form can facilitate the political democratization of a developmental state. This study concludes that although bureaucracy is often regarded as dysfunctional, it can be instrumental in the democratization process in the context of the developmental state.

scholarly journals LEADERSHIP STYLE AND EMPLOYEES’ PERFORMANCE IN PAKISTAN: THE MEDIATING ROLE OF ORGANISATIONAL COMMITMENT

2020 ◽  
Author(s):  
Muhammad Abbas ◽  
Asif Ali ◽  
Muhammad Ahsan Khalid
Keyword(s):  
Conceptual Model ◽  
Leadership Style ◽  
Employee Performance ◽  
Critical Role ◽  
Organisational Commitment ◽  
Organisational Performance ◽  
Missing Link ◽  
Mediating Role ◽  
The Relationship

The paper investigates the critical role of organisational commitment between leadership style and employees’ performance. Generally, the relationship between leadership style and the organisational performance has been discussed widely but ignoring the employees’ performance. It has been accepted that the organisational commitment leads to higher employee performance but the existing literature has not focused much on this view. A conceptual model has been developed which links the constructs together.The model reveals the missing link of organisational commitment between leadership style and employees’ performance. The sample of 242 was collected from the managers and employees of manufacturing and service organisations. The finding confirmed that organisational commitment acted as a mediator between the leadership style and employees’ performance.  

scholarly journals The Missing Link - Likely Pathogenetic Role of GM3 and Other Gangliosides in the Development of Diabetic Nephropathy

2015 ◽  
Vol 40 (3) ◽  
pp. 306-314 ◽  
Author(s):  
Igor Vukovic ◽  
Josko Bozic ◽  
Anita Markotic ◽  
Srecko Ljubicic ◽  
Tina Ticinovic Kurir
Keyword(s):  
Diabetic Nephropathy ◽  
Missing Link ◽  
Pathogenetic Role

Secessionist conflict as diversion from inequality: The missing link between grievance and repression

2021 ◽  
pp. 073889422110553
Author(s):  
Valery Dzutsati
Keyword(s):  
Social Status ◽  
Strong Support ◽  
Self Determination ◽  
Resource Reallocation ◽  
Dominant Group ◽  
National Scale ◽  
Missing Link ◽  
Horizontal Inequality ◽  
Vertical Inequality

Why do some secessionist claims turn violent and others stay peaceful? This study elucidates the role of inequality and diversionary tactics of states in secessionist violence. Horizontal inequality increases the grievances of minorities and fuels rebellion. States with high vertical inequality prefer to suppress peripheries instead of increasing redistribution and alleviating their material grievances. States shun redistributing toward peripheral regions because sharing with one group prompts demands for redistribution among other groups, including the dominant group. Fearing resource reallocation at the national scale and potential loss of their elevated social status, the elites opt for violent solutions for secessionist crises. Using a new dataset on self-determination movements I test these conjectures and find strong support for them.

scholarly journals Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link

2020 ◽  
Vol 21 (14) ◽  
pp. 4822
Author(s):  
Arvand Asghari ◽  
Michihisa Umetani
Keyword(s):  
United States ◽  
Cardiovascular Disease ◽  
Estrogen Receptor ◽  
Risk Factor ◽  
Cause Of Death ◽  
The United States ◽  
Missing Link ◽  
Receptor Modulator ◽  
Obesity And Cancer

Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States. Cancer follows as the second deadliest disease, and a link between obesity and cancer has been suggested. However, it is very hard to establish an exact connection between obesity and cancers due to the multifactorial nature of obesity. Hypercholesterolemia is a comorbidity of obesity and also linked to several cancers. Recently a cholesterol metabolite 27-hydroxycholesterol (27HC) was found to be an endogenous selective estrogen receptor modulator (SERM), which opened new doors toward several interesting studies on the role of this molecule in biological disorders. It is speculated that 27HC might be the missing link in the obesity and cancer chain. Here, we explored the effects of 27-hydroxycholesterol on obesity and cancers with a focus on the SERM capacity of 27HC.

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