scholarly journals Copy Number Variation in Fungi and Its Implications for Wine Yeast Genetic Diversity and Adaptation

2018 ◽  
Vol 9 ◽  
Author(s):  
Jacob L. Steenwyk ◽  
Antonis Rokas
Keyword(s):  
Genetic Diversity ◽  
Copy Number Variation ◽  
Copy Number ◽  
Wine Yeast ◽  
Number Variation ◽  
Yeast Genetic

scholarly journals Copy number variation in fungi and its implications for wine yeast genetic diversity and adaptation

2017 ◽  
Author(s):  
Jacob L. Steenwyk ◽  
Antonis Rokas
Keyword(s):  
Genetic Diversity ◽  
Copy Number ◽  
Molecular Mechanisms ◽  
Phenotypic Diversity ◽  
Wine Yeast ◽  
Nucleotide Polymorphisms ◽  
Wide Range ◽  
Number Variation ◽  
Fungal Populations ◽  
Yeast Genetic

AbstractIn recent years, copy number (CN) variation has emerged as a new and significant source of genetic polymorphisms contributing to the phenotypic diversity of populations. CN variants are defined as genetic loci that, due to duplication and deletion, vary in their number of copies across individuals in a population. CN variants range in size from 50 base pairs to whole chromosomes, can influence gene activity, and are associated with a wide range of phenotypes in diverse organisms, including the budding yeastSaccharomyces cerevisiae.In this review, we introduce CN variation, discuss the genetic and molecular mechanisms implicated in its generation, how they can contribute to genetic and phenotypic diversity in fungal populations, and consider how CN variants may influence wine yeast adaptation in fermentation-related processes. In particular, we focus on reviewing recent work investigating the contribution of changes in CN of fermentation-related genes associated with the adaptation and domestication of yeast wine strains and offer notable illustrations of such changes, including the high levels of CN variation among theCUPgenes, which confer resistance to copper, and the preferential deletion and duplication of theMALIandMAL3loci, respectively, which are responsible for metabolizing maltose and sucrose. Based on the available data, we propose that CN variation is a substantial dimension of yeast genetic diversity that occurs largely independent of single nucleotide polymorphisms. As such, CN variation harbors considerable potential for understanding and manipulating yeast strains in the wine fermentation environment and beyond.

scholarly journals Genetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation

2020 ◽  
Vol Volume 13 ◽  
pp. 4531-4545
Author(s):  
Christina S Saghaug ◽  
Christian Klotz ◽  
Juha P Kallio ◽  
Toni Aebischer ◽  
Nina Langeland ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Copy Number Variation ◽  
Giardia Lamblia ◽  
Copy Number ◽  
Number Variation

scholarly journals Copy number variation and genetic diversity of MHC Class IIb alleles in an alien population of Xenopus laevis

2015 ◽  
Vol 67 (10) ◽  
pp. 591-603 ◽  
Author(s):  
Barbara K. Mable ◽  
Elizabeth Kilbride ◽  
Mark E. Viney ◽  
Richard C. Tinsley
Keyword(s):  
Genetic Diversity ◽  
Xenopus Laevis ◽  
Copy Number Variation ◽  
Copy Number ◽  
Number Variation ◽  
Mhc Class Iib ◽  
Class Iib

scholarly journals SLA-1 Genetic Diversity in Pigs: Extensive Analysis of Copy Number Variation, Heterozygosity, Expression, and Breed Specificity

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Minh Thong Le ◽  
Hojun Choi ◽  
Hyejeong Lee ◽  
Van Chanh Quy Le ◽  
Byeongyong Ahn ◽  
...  
Keyword(s):  
Genetic Diversity ◽  
Copy Number Variation ◽  
Copy Number ◽  
Extensive Analysis ◽  
Number Variation

Identification of Novel Germline and Tumor-Specific Nucleotide Variants and Copy Number Variation in Clival Chordomas by Exome Sequencing

2015 ◽  
Vol 76 (S 01) ◽  
Author(s):  
Georgios Zenonos ◽  
Peter Howard ◽  
Maureen Lyons-Weiler ◽  
Wang Eric ◽  
William LaFambroise ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Exome Sequencing ◽  
Copy Number ◽  
Number Variation ◽  
Specific Nucleotide

The impact of paralog genes: detection of copy number variation in spinal muscle atrophy patients

BIOCELL ◽  
2018 ◽  
Vol 42 (3) ◽  
pp. 87-91 ◽  
Author(s):  
Sergio LAURITO ◽  
Juan A. CUETO ◽  
Jimena PEREZ ◽  
Mar韆 ROQU�
Keyword(s):  
Copy Number Variation ◽  
Muscle Atrophy ◽  
Copy Number ◽  
Number Variation ◽  
The Impact
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