scholarly journals Antibacterial Activity of 1-[(2,4-Dichlorophenethyl)amino]-3-Phenoxypropan-2-ol against Antibiotic-Resistant Strains of Diverse Bacterial Pathogens, Biofilms and in Pre-clinical Infection Models

2017 ◽  
Vol 8 ◽  
Author(s):  
Valerie Defraine ◽  
Laure Verstraete ◽  
Françoise Van Bambeke ◽  
Ahalieyah Anantharajah ◽  
Eleanor M. Townsend ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Bacterial Pathogens ◽  
Clinical Infection ◽  
Antibiotic Resistant ◽  
Infection Models ◽  
Resistant Strains

scholarly journals Genome sequence of Vibrio sp. SALL 6 isolated from shellfish

2019 ◽  
Vol 2 (1) ◽  
Author(s):  
Vengadesh Letchumanan ◽  
Hooi-Leng Ser ◽  
Wen-Si Tan ◽  
Kok-Gan Chan ◽  
Nurul-Syakima Ab Mutalib
Keyword(s):  
United States ◽  
Genome Sequence ◽  
East Asian ◽  
Foodborne Pathogen ◽  
Clinical Infection ◽  
Asian Countries ◽  
High Quality ◽  
Antibiotic Resistant ◽  
Resistant Strains ◽  
High Quality Genome

Members of the Vibrionaceae family are well known as foodborne pathogen that cause hazard to human in many forms of clinical infection and also affecting aquaculture via infection to livestock. This pathogen has caused seafood associated gastroenteritis cases in many countries including United States, Asian, and South East Asian countries. Antibiotics are usually used as prophylactic and therapeutic to manage the rising Vibrio infections, however, this in turn led to emergence of antibiotic resistant strains in the environments. Vibrio sp. SALL 6 isolated from shellfish was selected for genome sequencing to further explore its antimicrobial traits. Here, a high-quality genome sequence of Vibrio sp. SALL 6 is reported, while its genome reveals a potential for future antibiotic resistance managements.

Comparison of the activity spectra against pathogens of bacterial strains producing a mutacin or a lantibiotic

2001 ◽  
Vol 47 (4) ◽  
pp. 322-331 ◽  
Author(s):  
Hélène Morency ◽  
Marilaine Mota-Meira ◽  
Gisèle LaPointe ◽  
Christophe Lacroix ◽  
Marc C Lavoie
Keyword(s):  
Drug Resistance ◽  
Campylobacter Jejuni ◽  
Bacterial Pathogens ◽  
The Other ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Major Threat ◽  
Antibiotic Compounds ◽  
Resistant Strains ◽  
Further Development

The increase of drug resistance among bacterial pathogens is currently a major threat in hospital settings. New and more efficient antibiotic compounds have to be developed to fight infectious diseases. In the present work, a deferred antagonism test was used to determine the activity of different bacterial strains producing either a mutacin or a lantibiotic against bacterial pathogens. The mutacins A, B, C, D, I, K, L, M, and nisins A and Z were active against all enterococci tested. Mutacins A and B, and nisins A and Z inhibited all the staphylococci tested. Except for the strains producing mutacins P, Q, and X, all the other producing strains inhibited the streptococci tested. Mutacins A, B, I, J, T, nisins A and Z, and epidermin inhibited the two antibiotic-resistant strains of Neisseria gonorrhoeae tested. Mutacins A, B, C, D, and nisins A and Z inhibited Campylobacter jejuni and Helicobacter pylori. Thus, the wide activity spectra of nisin A and Z are confirmed. These results also indicate that many of the mutacins, especially those of groups A, B, C, D, I, J, K, L, M, and T, could be candidates for further development as useful antibiotics.Key words: mutacin, lantibiotic, bacteriocin, antibiotic.

Antibacterial Activity of HR-756, Cefoxitin and Cefuroxime against Multiply Antibiotic-Resistant Strains of Enterobacteriaceae and Pseudomonas aeruginosa

Chemotherapy ◽  
1980 ◽  
Vol 26 (5) ◽  
pp. 334-343 ◽  
Author(s):  
Nicholas J. Legakis ◽  
Dimitris A. Kafetzis ◽  
Constantine J. Papadatos ◽  
John Th. Papavassiliou
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Antibiotic Resistant ◽  
Resistant Strains

scholarly journals Exploration of antibacterial metabolites producing marine bacteria from Sundarbans, Bangladesh

2015 ◽  
Vol 18 (1) ◽  
pp. 53-60
Author(s):  
Ashish Kumar Sarker ◽  
Md Anwarul Haque ◽  
Mohammad Sayful Islam ◽  
Md Ajijur Rahman ◽  
Md Anwar Ul Islam
Keyword(s):  
Antibacterial Activity ◽  
Marine Bacteria ◽  
Pathogenic Bacteria ◽  
Pharmaceutical Journal ◽  
Soil Samples ◽  
Antibiotic Resistant ◽  
Term Basis ◽  
Resistant Strains ◽  
Marine Soil

To combat the increasing numbers of antibiotic resistant strains of pathogenic bacteria new source of antibacterial agents are desperately needed. This study was aimed to discover new marine bacteria having antibacterial activity from marine soil samples of Sundarbans, Bangladesh. Using starch-casein-nitrate-agar medium thirty nine marine bacteria colonies were isolated as pure isolates from nine marine soil samples. Each of the isolates was preserved in both short term and long term basis. Based on the aerial and substrate mycelia color of the isolates they were grouped into five color series and were screened for their antibacterial activity against a series of test bacteria. Among thirty nine pure isolates twenty four isolates (61.5%) exhibited moderate to high activity against three grampositive and four gram-negative bacteria. This is due to the antibacterial metabolites secreted in the medium by most of the isolates. It suggested that Sundarbans may be an interesting, valuable and potential source for the exploration of novel marine bacteria with the potential to yield useful new antibacterial secondary metabolites of pharmaceutical interest.Bangladesh Pharmaceutical Journal 18(1): 53-60, 2015

scholarly journals Antibacterial Co(II), Cu(II), Ni(II) and Zn(II) Complexes of Thiadiazoles Schiff Bases

2001 ◽  
Vol 8 (2) ◽  
pp. 95-101 ◽  
Author(s):  
Zahid H. Chohan ◽  
Maimoon F. Jaffery ◽  
Claudiu T. Supuran
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Schiff Bases ◽  
Bacterial Species ◽  
Analytical Data ◽  
Bacterial Strains ◽  
Antibiotic Resistant ◽  
Resistant Strains ◽  
New Compounds

Schiff bases were obtained by condensation of 2-amino-l,3,4-thiadiazole with 5-substituted-salicylaldehydes which were further used to obtain complexes of the type [M(L)2]Cl2, where M=Co(II), Cu(II), Ni(II) or Zn(II). The new compounds described here have been characterized by physical, spectral and analytical data, and have been screened for antibacterial activity against several bacterial strains such as Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. The antibacterial potency of these Schiff bases increased upon chelation/complexation, against the tested bacterial species, opening new aproaches in the fight against antibiotic resistant strains.

Antibacterial Properties of Chinese Herbal Medicines against Nosocomial Antibiotic Resistant Strains of Pseudomonas aeruginosa in Taiwan

2007 ◽  
Vol 35 (06) ◽  
pp. 1047-1060 ◽  
Author(s):  
Ching-Shen Liu ◽  
Thau-Ming Cham ◽  
Cheng-Hong Yang ◽  
Hsueh-Wei Chang ◽  
Chia-Hong Chen ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibacterial Activity ◽  
Herbal Medicines ◽  
Diffusion Method ◽  
Resistant Bacteria ◽  
Herbal Extracts ◽  
Chinese Herbal Medicines ◽  
Antibiotic Resistant ◽  
Chinese Herbal ◽  
Resistant Strains

Pseudomonas aeruginosa is well-recognized as a nosocomial pathogen, which exhibits inherent drug resistance. In this study, the antibacterial activity of ethanol extracts of 58 Chinese herbal medicines used in Taiwan were tested against 89 nosocomial antibiotic resistant strains of Pseudomonas aeruginosa. The results gathered by the disc diffusion method showed that 26 out of the 58 herbal extracts exhibited antibacterial activity. Among the 26 herbal extracts, 10 extracts showed broad-spectrum antibacterial activities and were selected for further antibacterial property assay. The minimum inhibitory concentrations (MIC) of the active partition fractions ranged from 0.25 to 11.0 mg/L. The presence of flavonoid compounds in the active fractions of test herbal extracts was observed by the TLC-bioautography. The results from the time-kill assay revealed that most of the herbal extracts completely killed the test organisms within 4 hours. Exposure of the test strains to a sub-MIC level of the herbal extracts for 10 consecutive subcultures did not induce resistance to the active components. A combination of the active herbal fractions with antibiotics showed that one of the herbal medicines, the hexane fraction of Ramulus Cinnamomi, possessed a synergistic effect with tetracycline, gentamycin, and streptomycin. In conclusion, the tested Chinese medical herbs have the potential to be developed into natural antibiotics. This is the first evaluation for screening large amounts of medical plants against nosocomial antibiotic resistant bacteria in Taiwan.

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