scholarly journals Amino Acid Substitutions Associated with Avian H5N6 Influenza A Virus Adaptation to Mice

2017 ◽  
Vol 8 ◽  
Author(s):  
Chunmao Zhang ◽  
Zongzheng Zhao ◽  
Zhendong Guo ◽  
Jiajie Zhang ◽  
Jiaming Li ◽  
...  
Keyword(s):  
Amino Acid ◽  
Influenza A Virus ◽  
Influenza A ◽  
Amino Acid Substitutions ◽  
Virus Adaptation

scholarly journals Effects of single-point amino acid substitutions on the structure and function neuraminidase proteins in influenza A virus

2008 ◽  
Vol 52 (4) ◽  
pp. 216-223 ◽  
Author(s):  
Takuya Yano ◽  
Eri Nobusawa ◽  
Alexander Nagy ◽  
Setsuko Nakajima ◽  
Katsuhisa Nakajima
Keyword(s):  
Amino Acid ◽  
Influenza A Virus ◽  
Influenza A ◽  
Single Point ◽  
Structure And Function ◽  
Amino Acid Substitutions ◽  
And Function

scholarly journals Genetic diversification of H5N1 highly pathogenic avian influenza A virus during replication in wild ducks

2011 ◽  
Vol 92 (9) ◽  
pp. 2105-2110 ◽  
Author(s):  
Yohei Watanabe ◽  
Madiha S. Ibrahim ◽  
Hany F. Ellakany ◽  
Hatem S. Abd El-Hamid ◽  
Kazuyoshi Ikuta
Keyword(s):  
Amino Acid ◽  
Avian Influenza ◽  
Influenza A Virus ◽  
Influenza A ◽  
Highly Pathogenic Avian Influenza ◽  
Amino Acid Substitutions ◽  
Highly Pathogenic ◽  
Pathogenic Avian Influenza ◽  
Novel Variants ◽  
Avian Influenza A Virus

Highly pathogenic avian influenza A virus subtype H5N1 can potentially generate novel variants during replication of infected hosts. To determine which H5N1 variants predominate in wild birds, we determined the sequences of RT-PCR amplified viral genes from several organs of infected chickens and ducks from Egypt, where H5N1 outbreaks in birds are endemic. Comparison of the sequences in viruses from trachea, lung, brain and liver revealed diversification with different amino acid substitutions in different ducks, but no diversification in chickens. These specific amino acid substitutions were rare among viruses currently circulating in Egypt. In addition, the H5N1 variants showed distinct growth kinetics in duck, canine and human cells. Our findings suggested that ducks can generate H5N1 variants with novel amino acid substitutions that might serve as aetiological agents for new influenza virus outbreaks and epidemics.

Effects of hemagglutinin amino acid substitutions in H9 influenza A virus escape mutants

2016 ◽  
Vol 161 (12) ◽  
pp. 3515-3520 ◽  
Author(s):  
Irina A. Rudneva ◽  
Tatiana A. Timofeeva ◽  
Anna V. Ignatieva ◽  
Aleksandr A. Shilov ◽  
Natalia A. Ilyushina
Keyword(s):  
Amino Acid ◽  
Influenza A Virus ◽  
Influenza A ◽  
Amino Acid Substitutions ◽  
Virus Escape ◽  
Escape Mutants

scholarly journals Biological properties of influenza A virus mutants with amino acid substitutions in the HA2 glycoprotein of the HA1/HA2 interaction region

2019 ◽  
Vol 100 (9) ◽  
pp. 1282-1292
Author(s):  
L. Jakubcová ◽  
M. Vozárová ◽  
J. Hollý ◽  
K. Tomčíková ◽  
M. Fogelová ◽  
...  
Keyword(s):  
Amino Acid ◽  
Influenza A Virus ◽  
Influenza A ◽  
Biological Properties ◽  
Interaction Region ◽  
Amino Acid Substitutions
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