scholarly journals Antimicrobial Resistance of Salmonella enterica Serovar Typhimurium in Shanghai, China

2017 ◽  
Vol 8 ◽  
Author(s):  
Jinyan Wang ◽  
Yongrui Li ◽  
Xuebin Xu ◽  
Beibei Liang ◽  
Fuli Wu ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Serovar Typhimurium

scholarly journals Whole-Genome Sequences of 66 Incompatibility Group FIB Plasmid-Carrying Salmonella enterica Serovar Typhimurium Isolates from Food Animal Sources

2020 ◽  
Vol 9 (5) ◽  
Author(s):  
Nesreen H. Aljahdali ◽  
Steven L. Foley ◽  
Jing Han ◽  
Yasser M. Sanad ◽  
Rajesh Nayak ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Resistance Genes ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Incompatibility Group ◽  
Content Type ◽  
Factors Associated ◽  
Food Animal ◽  
Antimicrobial Resistance Genes ◽  
Serovar Typhimurium

Sixty-six Salmonella enterica serovar Typhimurium isolates carrying incompatibility group FIB (IncFIB) plasmids were sequenced to further characterize the IncFIB plasmid-encoded factors associated with virulence and antimicrobial resistance genes. In addition to the IncFIB plasmid, many of these isolates harbored additional plasmids encoding virulence and antimicrobial resistance genes.

scholarly journals Genotypic and Phenotypic Characterization of Incompatibility Group FIB Positive Salmonella enterica Serovar Typhimurium Isolates from Food Animal Sources

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1307
Author(s):  
Nesreen H. Aljahdali ◽  
Bijay K. Khajanchi ◽  
Kennedi Weston ◽  
Joanna Deck ◽  
Justin Cox ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Salmonella Enterica ◽  
Virulence Genes ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Incompatibility Group ◽  
Cell Counts ◽  
Food Animal ◽  
Animal Populations ◽  
Plasmid Replicon ◽  
Serovar Typhimurium

Salmonella enterica is one of the most common bacterial foodborne pathogens in the United States, causing illnesses that range from self-limiting gastroenteritis to more severe, life threatening invasive disease. Many Salmonella strains contain plasmids that carry virulence, antimicrobial resistance, and/or transfer genes which allow them to adapt to diverse environments, and these can include incompatibility group (Inc) FIB plasmids. This study was undertaken to evaluate the genomic and phenotypic characteristics of IncFIB-positive Salmonella enterica serovar Typhimurium isolates from food animal sources, to identify their plasmid content, assess antimicrobial resistance and virulence properties, and compare their genotypic isolates with more recently isolated S. Typhimurium isolates from food animal sources. Methods: We identified 71 S. Typhimurium isolates that carried IncFIB plasmids. These isolates were subjected to whole genome sequencing and evaluated for bacteriocin production, antimicrobial susceptibility, the ability to transfer resistance plasmids, and a subset was evaluated for their ability to invade and persist in intestinal human epithelial cells. Results: Approximately 30% of isolates (n = 21) displayed bacteriocin inhibition of Escherichia coli strain J53. Bioinformatic analyses using PlasmidFinder software confirmed that all isolates contained IncFIB plasmids along with multiple other plasmid replicon types. Comparative analyses showed that all strains carried multiple antimicrobial resistance genes and virulence factors including iron acquisition genes, such as iucABCD (75%), iutA (94%), sitABCD (76%) and sitAB (100%). In 17 cases (71%), IncFIB plasmids, along with other plasmid replicon types, were able to conjugally transfer antimicrobial resistance and virulence genes to the susceptible recipient strain. For ten strains, persistence cell counts (27%) were noted to be significantly higher than invasion bacterial cell counts. When the genome sequences of the study isolates collected from 1998–2003 were compared to those published from subsequent years (2005–2018), overlapping genotypes were found, indicating the perseverance of IncFIB positive strains in food animal populations. This study confirms that IncFIB plasmids can play a potential role in disseminating antimicrobial resistance and virulence genes amongst bacteria from several food animal species.

Antimicrobial resistance in Salmonella enterica serovar Typhimurium from human and animal sources in Italy

2008 ◽  
Vol 128 (3-4) ◽  
pp. 414-418 ◽  
Author(s):  
C. Graziani ◽  
L. Busani ◽  
A.M. Dionisi ◽  
C. Lucarelli ◽  
S. Owczarek ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Serovar Typhimurium

scholarly journals Evidence for a Chromosomally Located Third Integron in Salmonella enterica Serovar Typhimurium DT104b

2004 ◽  
Vol 48 (4) ◽  
pp. 1350-1352 ◽  
Author(s):  
M. Daly ◽  
J. Buckley ◽  
E. Power ◽  
S. Fanning
Keyword(s):  
Antimicrobial Resistance ◽  
Genetic Mapping ◽  
Salmonella Enterica ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Bacterial Chromosome ◽  
Class 1 Integron ◽  
Phage Types ◽  
Serovar Typhimurium ◽  
Class 1

ABSTRACT Salmonella enterica serovar Typhimurium isolates of phage types DT104 and DT104b are frequently associated with multiple antimicrobial resistance. We describe the characterization of a class 1 integron containing dfrA1 and aadA1, genes from two Salmonella serovar Typhimurium DT104b isolates. Genetic mapping located the integron to the bacterial chromosome in each case.

scholarly journals Inhibitory Concentrations of Ciprofloxacin Induce an Adaptive Response Promoting the Intracellular Survival of Salmonella enterica Serovar Typhimurium

mBio ◽  
2021 ◽  
Author(s):  
Sushmita Sridhar ◽  
Sally Forrest ◽  
Derek Pickard ◽  
Claire Cormie ◽  
Emily A. Lees ◽  
...  
Keyword(s):  
Antimicrobial Resistance ◽  
Global Health ◽  
Salmonella Enterica ◽  
Adaptive Response ◽  
Salmonella Enterica Serovar Typhimurium ◽  
Intracellular Survival ◽  
First Line ◽  
Gram Negative ◽  
Serovar Typhimurium

Antimicrobial resistance is a critical concern in global health. In particular, there is rising resistance to fluoroquinolones, such as ciprofloxacin, a first-line antimicrobial for many Gram-negative pathogens.

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