scholarly journals Translation Initiation Factor eIF4E and eIFiso4E Are Both Required for Peanut stripe virus Infection in Peanut (Arachis hypogaea L.)

2017 ◽  
Vol 8 ◽  
Author(s):  
Manlin Xu ◽  
Hongfeng Xie ◽  
Juxiang Wu ◽  
Lianhui Xie ◽  
Jinguang Yang ◽  
...  
Keyword(s):  
Virus Infection ◽  
Arachis Hypogaea ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Arachis Hypogaea L ◽  
Peanut Stripe Virus

The Effect of Peanut Stripe Virus Infection on Peanut Composition

1989 ◽  
Vol 16 (1) ◽  
pp. 43-45 ◽  
Author(s):  
L. F. Ross ◽  
R. E. Lynch ◽  
E. J. Conkerton ◽  
J. W. Demski ◽  
D. J. Daigle ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Virus Infection ◽  
Tartaric Acid ◽  
Arachis Hypogaea ◽  
Total Carbohydrate ◽  
Soluble Phenolics ◽  
Arachis Hypogaea L ◽  
Peanut Stripe Virus ◽  
Potassium Magnesium ◽  
Carbohydrate Contents

Abstract Peanuts (Arachis hypogaea L.), cultivar Florunner, from plants inoculated with peanut stripe virus (PStV) were evaluated for chemical composition in comparison with peanuts from uninoculated plants. At harvest, seed were collected from plants which had been mechanically inoculated with PStV at emergence, or 20, 40, or 60 days after emergence and from uninoculated plants. The seed from PStV-infected plants had increases in manganese, selenium, zinc, iron, tartaric acid, raffinose, glucose, fructose, and total carbohydrate contents as compared to seed from uninoculated plants. Sucrose was increased in seed from plants inoculated with PStV at time of emergence. There was a decrease in the concentration of potassium, magnesium, protein, and total soluble phenolics of seed from plants inoculated with PStV. There were no changes in the concentration of stachyose, inositol, phosphorus, sulfur, calcium, copper, and oil.

scholarly journals Resistance to Vesicular Stomatitis Virus Infection Requires a Functional Cross Talk between the Eukaryotic Translation Initiation Factor 2α Kinases PERK and PKR

2004 ◽  
Vol 78 (23) ◽  
pp. 12747-12761 ◽  
Author(s):  
Dionissios Baltzis ◽  
Li-Ke Qu ◽  
Stavroula Papadopoulou ◽  
Jaime D. Blais ◽  
John C. Bell ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Virus Infection ◽  
Vesicular Stomatitis Virus ◽  
Translation Initiation ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Eukaryotic Translation ◽  
Eukaryotic Translation Initiation ◽  
Vesicular Stomatitis ◽  
Eif2α Kinase

ABSTRACT Phosphorylation of the alpha (α) subunit of the eukaryotic translation initiation factor 2 (eIF2) leads to the inhibition of protein synthesis in response to diverse stress conditions, including viral infection. The eIF2α kinase PKR has been shown to play an essential role against vesicular stomatitis virus (VSV) infection. We demonstrate here that another eIF2α kinase, the endoplasmic reticulum-resident protein kinase PERK, contributes to cellular resistance to VSV infection. We demonstrate that mouse embryonic fibroblasts (MEFs) from PERK−/− mice are more susceptible to VSV-mediated apoptosis than PERK+/+ MEFs. The higher replication capacity of VSV in PERK−/− MEFs results from their inability to attenuate viral protein synthesis due to an impaired eIF2α phosphorylation. We also show that VSV-infected PERK−/− MEFs are unable to fully activate PKR, suggesting a cross talk between the two eIF2α kinases in virus-infected cells. These findings further implicate PERK in virus infection, and provide evidence that the antiviral and antiapoptotic roles of PERK are mediated, at least in part, via the activation of PKR.

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