scholarly journals Full Genome Characterization of Human Influenza A/H3N2 Isolates from Asian Countries Reveals a Rare Amantadine Resistance-Conferring Mutation and Novel PB1-F2 Polymorphisms

2016 ◽  
Vol 7 ◽  
Author(s):  
Hassan Zaraket ◽  
Hiroki Kondo ◽  
Akinobu Hibino ◽  
Ren Yagami ◽  
Takashi Odagiri ◽  
...  
Keyword(s):  
Influenza A ◽  
Full Genome ◽  
Human Influenza ◽  
Asian Countries ◽  
Genome Characterization ◽  
Amantadine Resistance

scholarly journals Whole genome characterization of human influenza A(H1N1)pdm09 viruses isolated from Kenya during the 2009 pandemic

2016 ◽  
Vol 40 ◽  
pp. 98-103 ◽  
Author(s):  
George Gachara ◽  
Samuel Symekher ◽  
Michael Otieno ◽  
Japheth Magana ◽  
Benjamin Opot ◽  
...  
Keyword(s):  
Influenza A ◽  
Whole Genome ◽  
Human Influenza ◽  
Genome Characterization ◽  
Influenza A H1n1

scholarly journals Whole-Genome Characterization of a Novel Human Influenza A(H1N2) Virus Variant, Brazil

2017 ◽  
Vol 23 (1) ◽  
pp. 152-154 ◽  
Author(s):  
Paola Cristina Resende ◽  
Priscila Silva Born ◽  
Aline Rocha Matos ◽  
Fernando Couto Motta ◽  
Braulia Costa Caetano ◽  
...  
Keyword(s):  
Influenza A ◽  
Whole Genome ◽  
Human Influenza ◽  
Virus Variant ◽  
Genome Characterization ◽  
H1n2 Virus

scholarly journals Large-Scale Sequence Analysis of M Gene of Influenza A Viruses from Different Species: Mechanisms for Emergence and Spread of Amantadine Resistance

2009 ◽  
Vol 53 (10) ◽  
pp. 4457-4463 ◽  
Author(s):  
Yuki Furuse ◽  
Akira Suzuki ◽  
Hitoshi Oshitani
Keyword(s):  
Influenza Virus ◽  
Influenza A ◽  
Drug Resistant ◽  
Human Influenza ◽  
Influenza A Viruses ◽  
M Gene ◽  
Drug Pressure ◽  
Human Influenza Virus ◽  
Selective Pressures ◽  
Amantadine Resistance

ABSTRACT Influenza A virus infects many species, and amantadine is used as an antiviral agent. Recently, a substantial increase in amantadine-resistant strains has been reported, most of which have a substitution at amino acid position 31 in the M2 gene. Understanding the mechanism responsible for the emergence and spread of antiviral resistance is important for developing a treatment protocol for seasonal influenza and for deciding on a policy for antiviral stockpiling for pandemic influenza. The present study was conducted to identify the existence of drug pressure on the emergence and spread of amantadine-resistant influenza A viruses. We analyzed data on more than 5,000 virus sequences and constructed a phylogenetic tree to calculate selective pressures on sites in the M2 gene associated with amantadine resistance (positions 26, 27, 30, and 31) among different hosts. The phylogenetic tree revealed that the emergence and spread of the drug-resistant M gene in different hosts and subtypes were independent and not through reassortment. For human influenza virus, positive selection was detected only at position 27. Selective pressures on the sites were not always higher for human influenza virus than for viruses of other hosts. Additionally, selective pressure on position 31 did not increase after the introduction of amantadine. Although there is a possibility of drug pressure on human influenza virus, we could not find positive pressure on position 31. Because the recent rapid increase in drug-resistant virus is associated with the substitution at position 31, the resistance may not be related to drug use.

Full genome characterization of human Rotavirus A strains isolated in Cameroon, 2010–2011: Diverse combinations of the G and P genes and lack of reassortment of the backbone genes

2014 ◽  
Vol 28 ◽  
pp. 537-560 ◽  
Author(s):  
Valentine Ngum Ndze ◽  
Mathew Dioh Esona ◽  
Eric Akum Achidi ◽  
Kamga Hortense Gonsu ◽  
Renáta Dóró ◽  
...  
Keyword(s):  
Full Genome ◽  
Genome Characterization ◽  
Rotavirus A ◽  
Human Rotavirus

The first full genome characterization of an Iranian foot and mouth disease virus

2020 ◽  
Vol 279 ◽  
pp. 197888
Author(s):  
Hamideh Najafi ◽  
Mohammad Hossein FallahMehrabadi ◽  
Hossein Hosseini ◽  
Zahra Ziafati Kafi ◽  
Amir Modiri Hamdan ◽  
...  
Keyword(s):  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Full Genome ◽  
Genome Characterization ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Full genome characterization of two novel Alpha-coronavirus species from Italian bats

2019 ◽  
Vol 260 ◽  
pp. 60-66 ◽  
Author(s):  
Luca De Sabato ◽  
Davide Lelli ◽  
Francesca Faccin ◽  
Sabrina Canziani ◽  
Ilaria Di Bartolo ◽  
...  
Keyword(s):  
Full Genome ◽  
Genome Characterization

scholarly journals Isolation and Full-Genome Characterization of Nipah Viruses from Bats, Bangladesh

2019 ◽  
Vol 25 (1) ◽  
pp. 166-170 ◽  
Author(s):  
Danielle E. Anderson ◽  
Ariful Islam ◽  
Gary Crameri ◽  
Shawn Todd ◽  
Ausraful Islam ◽  
...  
Keyword(s):  
Full Genome ◽  
Genome Characterization

Avian-human influenza a reassortant viruses — Evaluation in humans and characterization of the genes specifying restricted replication in primates

1985 ◽  
Vol 3 ◽  
pp. 78
Author(s):  
Brian R. Murphy ◽  
Mark H. Snyder ◽  
Alicia J. Buckler-White ◽  
Marylou Clements ◽  
Robert F. Betts ◽  
...  
Keyword(s):  
Influenza A ◽  
Human Influenza ◽  
Reassortant Viruses
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