scholarly journals Glycine Cleavage Powers Photoheterotrophic Growth of Chloroflexus aurantiacus in the Absence of H2

2015 ◽  
Vol 6 ◽  
Author(s):  
Lian He ◽  
Yaya Wang ◽  
Le You ◽  
Yadana Khin ◽  
Joseph K.-H. Tang ◽  
...  
Keyword(s):  
Chloroflexus Aurantiacus ◽  
Glycine Cleavage ◽  
Photoheterotrophic Growth

Efficacy of Tryptophan for the Treatment of Nonketotic Hyperglycinemia: A New Therapeutic Approach for Modulating the N-Methyl-D-aspartate Receptor

PEDIATRICS ◽  
1995 ◽  
Vol 95 (1) ◽  
pp. 142-146
Author(s):  
Satoshi Matsuo ◽  
Fumio Inoue ◽  
Yoshihiro Takeuchi ◽  
Hiroshi Yoshioka ◽  
Akihiko Kinugasa ◽  
...  
Keyword(s):  
Excitatory Amino Acid ◽  
Muscular Hypotonia ◽  
Inherited Disease ◽  
Excitatory Amino Acid Receptors ◽  
Amino Acid Receptors ◽  
Aspartate Receptor ◽  
Cleavage Enzyme ◽  
Glycine Cleavage ◽  
Glycine Level ◽  
Nonketotic Hyperglycinemia

Nonketotic hyperglycinemia (NKH) is a rare inherited disease caused by a defect of the glycine cleavage enzyme.1 Especially in the neonatal type, neurological symptoms such as muscular hypotonia, seizures, respiratory distress, and lethargy develop rapidly, and the prognosis is unfavorable.1 Elevation of glycine in the cerebrospinal fluid (CSF) is thought to be responsible for these symptoms. However, management is quite difficult, because it is not well understood how elevation of glycine causes these symptoms. Lowering of the glycine level in CSF with sodium benzoate is not enough to avoid severe psychomotor and mental retardation. The N-methyl-D-aspartate (NMDA) receptor, which is one of the excitatory amino acid receptors, has a glycine binding site.2

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