scholarly journals Fecal microbiota transplantation and bacterial consortium transplantation have comparable effects on the re-establishment of mucosal barrier function in mice with intestinal dysbiosis

2015 ◽  
Vol 6 ◽  
Author(s):  
Ming Li ◽  
Pin Liang ◽  
Zhenzhen Li ◽  
Ying Wang ◽  
Guobin Zhang ◽  
...  
Keyword(s):  
Barrier Function ◽  
Fecal Microbiota Transplantation ◽  
Bacterial Consortium ◽  
Fecal Microbiota ◽  
Mucosal Barrier ◽  
Intestinal Dysbiosis ◽  
Mucosal Barrier Function

scholarly journals Fecal Microbiota Transplantation Protects the Intestinal Mucosal Barrier by Reconstructing the Gut Microbiota in a Murine Model of Sepsis

2021 ◽  
Vol 11 ◽  
Author(s):  
Xiaowei Gai ◽  
Huawei Wang ◽  
Yaqing Li ◽  
Haotian Zhao ◽  
Cong He ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Gut Microbiota ◽  
Murine Model ◽  
Barrier Function ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Mucosal Barrier ◽  
Gut Flora ◽  
Intestinal Mucosal Barrier ◽  
Mucosal Barrier Function

The gastrointestinal (GI) tract has long been hypothesized to play an integral role in the pathophysiology of sepsis, and gut microbiota (GM) dysbiosis may be the key factor. Previous studies have shown that the gut flora was significantly altered in critically ill patients. This study aimed to observe what kind of GM dysbiosis is in the early stage of sepsis and whether the application of fecal microbiota transplantation (FMT) can reconstruct the GM of septic mice and restore its protective function on the intestinal mucosal barrier. The study investigated the effect of FMT on gut microbiota, mucosal barrier function, inflammatory response, and survival in a murine model of sepsis established by cecal ligation and puncture (CLP). It is found that FMT can not only reduce morbidity and mortality and restore the abundance and diversity of the gut flora in septic mice, but can also improve the intestinal barrier function by reducing epithelial cell apoptosis, improving the composition of the mucus layer, upregulating the expression of tight junction proteins, and reducing intestinal permeability and the inflammatory response. After FMT, Lachnospiraceae contributed the most to intestinal protection through enhancement of the L-lysine fermentation pathway. FMT offers a microbe-mediated survival advantage in a murine model of sepsis. Therefore, an improved understanding of the connection between microbiota, and systemic illness may yield new therapeutic strategies for patients with sepsis.

Glucagon-Like Peptide-2 Improve Intestinal Mucosal Barrier Function in Aged Rats

2018 ◽  
Vol 22 (6) ◽  
pp. 731-738 ◽  
Author(s):  
Weiying Ren ◽  
Jiayu Wu ◽  
Li Li ◽  
Y. Lu ◽  
Y. Shao ◽  
...  
Keyword(s):  
Barrier Function ◽  
Mucosal Barrier ◽  
Aged Rats ◽  
Intestinal Mucosal Barrier ◽  
Mucosal Barrier Function ◽  
Glucagon Like Peptide
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