scholarly journals The Pathobiology of Neisseria gonorrhoeae Lower Female Genital Tract Infection

2011 ◽  
Vol 2 ◽  
Author(s):  
Jennifer L. Edwards ◽  
Emily K. Butler
Keyword(s):  
Tract Infection ◽  
Neisseria Gonorrhoeae ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Female Genital

scholarly journals Efficacy of an Immune Modulator in ExperimentalChlamydia trachomatisInfection of the Female Genital Tract

2006 ◽  
Vol 2006 ◽  
pp. 1-6
Author(s):  
Joseph M. Lyons ◽  
James I. Ito ◽  
Servaas A. Morré
Keyword(s):  
Tract Infection ◽  
Murine Model ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Response Modifier ◽  
Genital Tract Infection ◽  
Prophylactic Dose ◽  
Duration Of Infection ◽  
Immune Response Modifier ◽  
Female Genital

Objective.The aim of this study was to determine if vaginal application of the immune response modifier imiquimod (Aldara cream, 3M Pharmaceuticals, St Paul, Minn) would alter the course and/or outcome of female genital tract infection with a human isolate ofChlamydia trachomatisin a murine model.Methods.Groups of CF-1 mice were treated with Aldara on three different schedules: (1) ongoing beginning 5 days prior to and continuing through day 5 of infection; (2) a single prophylactic dose 2 hours prior to infection; and (3) therapeutic from day 4 to day 14 of infection. Mice were infected vaginally with a serovar D strain ofC trachomatis, and monitored by culture to determine the level of shedding and duration of infection.Results.We observed a significant reduction in both duration of infection and the level of shedding during the acute phase in mice treated on an ongoing basis commencing 5 days prior to infection. There was no effect with respect to the other regimens.Conclusion.These results demonstrate that ongoing Aldara treatment has efficacy and may enhance local innate immunity which reduces the duration of subsequent infection with human isolates ofC trachomatisin a murine model of female genital tract infection.

scholarly journals Adhesion Molecules Associated with Female Genital Tract Infection

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156605 ◽  
Author(s):  
Jamal Qualai ◽  
Jon Cantero ◽  
Lin-Xi Li ◽  
José Manuel Carrascosa ◽  
Eduard Cabré ◽  
...  
Keyword(s):  
Tract Infection ◽  
Adhesion Molecules ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Female Genital

Individual immunity and susceptibility to female genital tract infection

2000 ◽  
Vol 183 (1) ◽  
pp. 252-256 ◽  
Author(s):  
S WITKIN ◽  
I LINHARES ◽  
P GIRALDO ◽  
J JEREMIAS ◽  
W LEDGER
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Individual Immunity ◽  
Female Genital

Individual immunity and susceptibility to female genital tract infection

2000 ◽  
Vol 183 (1) ◽  
pp. 252-256 ◽  
Author(s):  
Steven S. Witkin ◽  
Iara Linhares ◽  
Paulo Giraldo ◽  
Jan Jeremias ◽  
William J. Ledger
Keyword(s):  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Genital Tract Infection ◽  
Individual Immunity ◽  
Female Genital

scholarly journals Neisseria gonorrhoeae Catalase Is Not Required for Experimental Genital Tract Infection despite the Induction of a Localized Neutrophil Response

2007 ◽  
Vol 75 (5) ◽  
pp. 2225-2233 ◽  
Author(s):  
Ángel A. Soler-García ◽  
Ann E. Jerse
Keyword(s):  
Tract Infection ◽  
Neisseria Gonorrhoeae ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Antioxidant Defenses ◽  
Wild Type ◽  
Genital Tract Infection ◽  
Estradiol Treatment ◽  
Significant Difference

ABSTRACT Neisseria gonorrhoeae produces several antioxidant defenses, including high levels of catalase, which may facilitate the persistence during an inflammatory response via neutralization of H2O2 produced by phagocytes. In vivo testing of the role of catalase in gonococcal survival is critical since several physiological factors impact interactions between N. gonorrhoeae and polymorphonuclear leukocytes (PMNs). Here we assessed the importance of gonococcal catalase in a surrogate model of female genital tract infection. Female BALB/c mice were treated with 17-β estradiol to promote susceptibility to N. gonorrhoeae and inoculated intravaginally with wild-type gonococci or a catalase (kat) deletion mutant. A localized PMN influx occurred in an average of 43 and 81% of mice infected with wild-type or kat mutant gonococci, respectively, and PMNs associated with numerous wild-type or catalase-deficient bacteria were observed in vaginal smears. The combined results of six experiments showed a significant difference in the number of days wild-type bacteria were recovered compared to the catalase-deficient gonococci. However, there was much variability between experiments, and we found no correlation between PMN influx, colonization load, and clearance of wild-type or kat mutant bacteria. Estradiol treatment did not impair bacterial uptake, the luminol-dependent chemiluminescence response, or the killing capacity of isolated murine PMNs against N. gonorrhoeae or Staphylococcus aureus. Our data suggest N. gonorrhoeae is not significantly challenged by H2O2 produced by PMNs in the murine lower genital tract; alternatively, redundant defense mechanisms may protect the gonococcus from reactive oxygen species during infection.

scholarly journals Human Female Genital Tract Infection by the Obligate Intracellular Bacterium Chlamydia trachomatis Elicits Robust Type 2 Immunity

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58565 ◽  
Author(s):  
Rodolfo D. Vicetti Miguel ◽  
Stephen A. K. Harvey ◽  
William A. LaFramboise ◽  
Seth D. Reighard ◽  
Dean B. Matthews ◽  
...  
Keyword(s):  
Chlamydia Trachomatis ◽  
Tract Infection ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Obligate Intracellular Bacterium ◽  
Human Female ◽  
Genital Tract Infection ◽  
Obligate Intracellular ◽  
Female Genital
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