scholarly journals In vivo Imaging With 18F-FDG- and 18F-Florbetaben-PET/MRI Detects Pathological Changes in the Brain of the Commonly Used 5XFAD Mouse Model of Alzheimer's Disease

2020 ◽  
Vol 7 ◽  
Author(s):  
Timon N. Franke ◽  
Caroline Irwin ◽  
Thomas A. Bayer ◽  
Winfried Brenner ◽  
Nicola Beindorff ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
In Vivo Imaging ◽  
Pathological Changes ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse ◽  
18F Fdg ◽  
The Brain

scholarly journals Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

2014 ◽  
Vol 35 (8) ◽  
pp. 1792-1800 ◽  
Author(s):  
Michael B. Dinkins ◽  
Somsankar Dasgupta ◽  
Guanghu Wang ◽  
Gu Zhu ◽  
Erhard Bieberich
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Plaque ◽  
Model Of Alzheimer’S Disease ◽  
Plaque Load ◽  
5Xfad Mouse

scholarly journals A rationally designed small molecule for identifying an in vivo link between metal–amyloid-β complexes and the pathogenesis of Alzheimer's disease

2015 ◽  
Vol 6 (3) ◽  
pp. 1879-1886 ◽  
Author(s):  
Michael W. Beck ◽  
Shin Bi Oh ◽  
Richard A. Kerr ◽  
Hyuck Jin Lee ◽  
So Hee Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Small Molecule ◽  
Amyloid Β ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse ◽  
Target Metal

An in vivo chemical tool designed to target metal−Aβ complexes and modulate their activity was applied to the 5XFAD mouse model of Alzheimer’s disease (AD) demonstrating the involvement of metal−Aβ in AD pathology.

scholarly journals Altered Brain Adiponectin Receptor Expression in the 5XFAD Mouse Model of Alzheimer’s Disease

2020 ◽  
Vol 13 (7) ◽  
pp. 150 ◽  
Author(s):  
Anishchal A. Pratap ◽  
R. M. Damian Holsinger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Receptor Expression ◽  
Wild Type ◽  
Model Of Alzheimer’S Disease ◽  
Activated State ◽  
5Xfad Mouse ◽  
Neuronal Expression ◽  
The Brain

Metabolic syndromes share common pathologies with Alzheimer’s disease (AD). Adiponectin, an adipocyte-derived protein, regulates energy metabolism via its receptors, AdipoR1 and AdipoR2. To investigate the distribution of adiponectin receptors (AdipoRs) in Alzheimer’s, we examined their expression in the aged 5XFAD mouse model of AD. In age-matched wild-type mice, we observed neuronal expression of both ARs throughout the brain as well as endothelial expression of AdipoR1. The pattern of receptor expression in the aged 5XFAD brain was significantly perturbed. Here, we observed decreased neuronal expression of both ARs and decreased endothelial expression of AdipoR1, but robust expression of AdipoR2 in activated astrocytes. We also observed AdipoR2-expressing astrocytes in the dorsomedial hypothalamic and thalamic mediodorsal nuclei, suggesting the possibility that astrocytes utilise AdipoR2 signalling to fuel their activated state in the AD brain. These findings provide further evidence of a metabolic disturbance and demonstrate a potential shift in energy utilisation in the AD brain, supporting imaging studies performed in AD patients.

scholarly journals Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease

2020 ◽  
Vol 14 ◽  
Author(s):  
Jeremiah K. H. Lim ◽  
Qiao-Xin Li ◽  
Zheng He ◽  
Algis J. Vingrys ◽  
Holly R. Chinnery ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Structural Changes ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse

Exercise‐Induced Alterations in TrkB expression in the 5XFAD Mouse Model of Alzheimer’s Disease

2021 ◽  
Vol 17 (S2) ◽  
Author(s):  
Christopher Moylan ◽  
Thanh Vinh Cao ◽  
Quy‐Susan Huynh ◽  
Anishchal Pratap ◽  
R. M. Damian Holsinger
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
5Xfad Mouse ◽  
Exercise Induced
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