scholarly journals Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

2019 ◽  
Vol 10 ◽  
Author(s):  
Florence Ecoeur ◽  
Jessica Weiss ◽  
Klemens Kaupmann ◽  
Samuel Hintermann ◽  
David Orain ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Orphan Receptor ◽  
Gamma Activity ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
Human Keratinocyte ◽  
Skin Responses

scholarly journals Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

Immunity ◽  
2012 ◽  
Vol 36 (2) ◽  
pp. 201-214 ◽  
Author(s):  
Veronica Santarlasci ◽  
Laura Maggi ◽  
Manuela Capone ◽  
Valentina Querci ◽  
Luca Beltrame ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Orphan Receptor ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells

The Effect of Vitamin A Supplementation on Retinoic Acid-Related Orphan Receptor γt (RORγt) and Interleukin-17 (IL-17) Gene Expression in Avonex-Treated Multiple Sclerotic Patients

2013 ◽  
Vol 51 (3) ◽  
pp. 749-753 ◽  
Author(s):  
Niyaz Mohammadzadeh Honarvar ◽  
Mohammad Hossein Harirchian ◽  
Fariba Koohdani ◽  
Feridoun Siassi ◽  
Mina Abdolahi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Retinoic Acid ◽  
Vitamin A ◽  
Orphan Receptor ◽  
Interleukin 17 ◽  
Vitamin A Supplementation

scholarly journals Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Ning Qu ◽  
Mingli Xu ◽  
Izuru Mizoguchi ◽  
Jun-ichi Furusawa ◽  
Kotaro Kaneko ◽  
...  
Keyword(s):  
Th17 Cell ◽  
Th17 Cells ◽  
Functional Role ◽  
Inflammatory Diseases ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
Autoimmune Encephalomyelitis ◽  
Experimental Autoimmune

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

A case of refractory lupus nephritis complicated by psoriasis vulgaris that was controlled with secukinumab

Lupus ◽  
2018 ◽  
Vol 27 (7) ◽  
pp. 1202-1206 ◽  
Author(s):  
Y Satoh ◽  
K Nakano ◽  
H Yoshinari ◽  
S Nakayamada ◽  
S Iwata ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Lupus Erythematosus ◽  
Psoriasis Vulgaris ◽  
Tissue Sample ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Biopsy Tissue ◽  
Interleukin 17A

It has been reported that T helper 17 cells are involved in the pathogenesis of systemic lupus erythematosus, but there is no report on interleukin-17-targeted therapy. We report a case of a 62-year-old female who presented with psoriasis vulgaris and refractory lupus nephritis. Because her conditions were resistant to conventional treatment, and flow cytometry confirmed the proliferation of activated T helper 17 cells in peripheral blood, and examination of a renal biopsy tissue sample confirmed infiltration of numerous interleukin-17-positive lymphocytes to the renal interstitium, administration of the anti-interleukin-17A antibody secukinumab was initiated. After starting secukinumab the clinical and biological features were improved.

scholarly journals The Interleukin (IL) 17R/IL-22R Signaling Axis Is Dispensable for Vulvovaginal Candidiasis Regardless of Estrogen Status

2019 ◽  
Vol 221 (9) ◽  
pp. 1554-1563 ◽  
Author(s):  
Brian M Peters ◽  
Bianca M Coleman ◽  
Hubertine M E Willems ◽  
Katherine S Barker ◽  
Felix E Y Aggor ◽  
...  
Keyword(s):  
Gene Signature ◽  
Vulvovaginal Candidiasis ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
Interleukin 22 ◽  
Mucosal Tissues ◽  
Signaling Axis ◽  
Estrogen Administration

Abstract Candida albicans, a ubiquitous commensal fungus that colonizes human mucosal tissues and skin, can become pathogenic, clinically manifesting most commonly as oropharyngeal candidiasis and vulvovaginal candidiasis (VVC). Studies in mice and humans convincingly show that T-helper 17 (Th17)/interleukin 17 (IL-17)–driven immunity is essential to control oral and dermal candidiasis. However, the role of the IL-17 pathway during VVC remains controversial, with conflicting reports from human data and mouse models. Like others, we observed induction of a strong IL-17–related gene signature in the vagina during estrogen-dependent murine VVC. As estrogen increases susceptibility to vaginal colonization and resulting immunopathology, we asked whether estrogen use in the standard VVC model masks a role for the Th17/IL-17 axis. We demonstrate that mice lacking IL-17RA, Act1, or interleukin 22 showed no evidence for altered VVC susceptibility or immunopathology, regardless of estrogen administration. Hence, these data support the emerging consensus that Th17/IL-17 axis signaling is dispensable for the immunopathogenesis of VVC.

scholarly journals The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity

Immunity ◽  
2008 ◽  
Vol 29 (2) ◽  
pp. 205-216 ◽  
Author(s):  
Natascha Hermann-Kleiter ◽  
Thomas Gruber ◽  
Christina Lutz-Nicoladoni ◽  
Nikolaus Thuille ◽  
Friedrich Fresser ◽  
...  
Keyword(s):  
Lymphocyte Activation ◽  
Orphan Receptor ◽  
T Helper ◽  
T Helper 17 ◽  
Nuclear Orphan Receptor

scholarly journals Fenofibrate Inhibited the Differentiation of T Helper 17 CellsIn Vitro

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Zhou Zhou ◽  
Weiliang Sun ◽  
Ying Liang ◽  
Yanxiang Gao ◽  
Wei Kong ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Autoimmune Diseases ◽  
Th17 Cells ◽  
Transforming Growth Factor ◽  
Inflammatory Diseases ◽  
Lipid Lowering ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
Th17 Differentiation

Uncontrolled activity of T cells mediates autoimmune and inflammatory diseases such as multiple sclerosis, inflammatory bowel diseases, rheumatoid arthritis, type 1 diabetes, and atherosclerosis. Recent findings suggest that enhanced activity of interleukin-17 (IL-17) producing T helper 17 cells (Th17 cells) plays an important role in autoimmune diseases and inflammatory diseases. Previous papers have revealed that a lipid-lowering synthetic ligand of peroxisome proliferator-activated receptorα(PPARα), fenofibrate, alleviates both atherosclerosis and a few nonlipid-associated autoimmune diseases such as autoimmune colitis and multiple sclerosis. However, the link between fenofibrate and Th17 cells is lacking. In the present study, we hypothesized that fenofibrate inhibited the differentiation of Th17 cells. Our results showed that fenofibrate inhibited transforming growth factor-β(TGF-β) and IL-6-induced differentiation of Th17 cellsin vitro. However, other PPARαligands such as WY14643, GW7647 and bezafibrate did not show any effect on Th17 differentiation, indicating that this effect of fenofibrate might be PPARαindependent. Furthermore, our data showed that fenofibrate reduced IL-21 production and STAT3 activation, a critical signal in the Th17 differentiation. Thus, by ameliorating the differentiation of Th17 cells, fenofibrate might be beneficial for autoimmunity and inflammatory diseases.

Forkhead box P3-positive regulatory T-cells and interleukin 17-positive T-helper 17 cells in chronic inflammatory periodontal disease

2014 ◽  
Vol 49 (6) ◽  
pp. 817-826 ◽  
Author(s):  
V. P. B. Parachuru ◽  
D. E. Coates ◽  
T. J. Milne ◽  
H. M. Hussaini ◽  
A. M. Rich ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Periodontal Disease ◽  
Interleukin 17 ◽  
T Helper ◽  
T Helper 17 ◽  
T Helper 17 Cells ◽  
Forkhead Box P3 ◽  
Forkhead Box
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