scholarly journals Dual Regulation of Host TRAIP Post-translation and Nuclear/Plasma Distribution by Porcine Reproductive and Respiratory Syndrome Virus Non-structural Protein 1α Promotes Viral Proliferation

2018 ◽  
Vol 9 ◽  
Author(s):  
Peidian Shi ◽  
Yanxin Su ◽  
Ruiqiao Li ◽  
Lei Zhang ◽  
Chen Chen ◽  
...  
Keyword(s):  
Respiratory Syndrome Virus ◽  
Structural Protein ◽  
Plasma Distribution ◽  
Viral Proliferation

scholarly journals A 10-kDa Structural Protein of Porcine Reproductive and Respiratory Syndrome Virus Encoded by ORF2b

Virology ◽  
2001 ◽  
Vol 287 (1) ◽  
pp. 183-191 ◽  
Author(s):  
Wai-Hong Wu ◽  
Ying Fang ◽  
Rachel Farwell ◽  
Melissa Steffen-Bien ◽  
Raymond R.R Rowland ◽  
...  
Keyword(s):  
Respiratory Syndrome Virus ◽  
Structural Protein

scholarly journals The Glycosyltransferase ST3GAL2 Modulate the Proliferation and Inflammation Response in PRRSV Infection 

2021 ◽  
Author(s):  
Yinna Song ◽  
Yanyu Guo ◽  
Xiaoyang Li ◽  
Ruiqi Sun ◽  
Min Zhu ◽  
...  
Keyword(s):  
Cellular Immunity ◽  
Immune Escape ◽  
Cell Model ◽  
Inflammatory Factor ◽  
Potential Mechanism ◽  
Structural Protein ◽  
Acid Modification ◽  
Release Process ◽  
Viral Proliferation

Abstract The viral proliferation process of envelop viruses including invasion, assembly, and release process is impacted by glycosylation. Sialic acid modification mainly exists in the terminal glycosylation of proteins and lipids. In this study, the effect of porcine sialylglycosyltransferase (ST3GAL2) on virus proliferation, as well as regulation of inflammatory factor in PRRSV-infected 3D4/21 cell model were analyzed. The expression of ST3GAL2 was up-regulated in PRRSV-infected 3D4/21 cells. The expression of ST3GAL2 that promote the proliferation of PRRSV was determined by overexpression and interference experiment. The ST3GAL2 localizes to Golgi apparatus and interacts with PRRSV structural protein GP2a was verified by confocal microscopy and co-immnoprecipitation array, which may play roles in the assembly of PRRSV envelope and virus proliferation. The expression of ST3GAL2 also impacts the expression of inflammatory cytokines, which regulate cellular immunity and promote the immune escape of PRRSV from innate immunity. Our results highlighted a potential mechanism whereby ST3GAL2 promotes PRRSV proliferation and offers the anti-inflammatory role of ST3GAL2 in cellular immunity.

scholarly journals Antiviral Mechanism of Tea Polyphenols on Porcine Reproductive and Respiratory Syndrome Virus

2020 ◽  
Author(s):  
Wenjuan Dong ◽  
Xun Wang ◽  
Xiaoxiao Zhang ◽  
Zhenbang Zhu ◽  
Yaosheng Chen ◽  
...  
Keyword(s):  
Antiviral Agent ◽  
Tea Polyphenols ◽  
Respiratory Syndrome Virus ◽  
Structural Protein ◽  
Viral Attachment ◽  
New Horizons ◽  
Pre Treatment ◽  
Transcription Complexes ◽  
Main Components ◽  
And Control

Abstract Background: Neither inactivated vaccine nor attenuated vaccine can effectively prevent and control the infection and spread of porcine reproductive and respiratory syndrome virus (PRRSV). Therefore, it is necessary to broaden new horizons and to conceive effective preventive strategies. Tea polyphenols (TPP) are polyphenol in tea. The main components of TPP are catechins and their derivatives. TPP has many physiological activities and has certain antiviral and antifungal effects. But whether TPP owns anti-PRRSV activity remains unclear. Results: We found that TPP effectively inhibited PRRSV replication in Marc-145 cells by suppressing viral attachment and internalization. TPP exhibited a potent anti-PRRSV effect regardless of its pre-treatment or post-treatment. In addition, we demonstrated that TPP restrained PRRSV-induced p65 entry into the nucleus to suppress the activation of the NF-κB signaling pathway, which ultimately leads to the inhibition of the expression of inflammatory cytokines. Furthermore, TPP limited the synthesis of viral non-structural protein 2 (nsp2), the core component of viral replication transcription complexes, which may contribute to the inhibition of viral RNA replication. Conclusions: TPP has the potential to develop into an effective antiviral agent for PRRSV prevention and control in the future.

scholarly journals Identification of amino acid residues important for anti-IFN activity of porcine reproductive and respiratory syndrome virus non-structural protein 1

Virology ◽  
2012 ◽  
Vol 433 (2) ◽  
pp. 431-439 ◽  
Author(s):  
Lalit K. Beura ◽  
Sakthivel Subramaniam ◽  
Hiep L.X. Vu ◽  
Byungjoon Kwon ◽  
Asit K. Pattnaik ◽  
...  
Keyword(s):  
Amino Acid ◽  
Respiratory Syndrome Virus ◽  
Amino Acid Residues ◽  
Structural Protein
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