scholarly journals Influenza Vaccine-Induced Antibody Responses Are Not Impaired by Frailty in the Community-Dwelling Elderly With Natural Influenza Exposure

2018 ◽  
Vol 9 ◽  
Author(s):  
Vipin Narang ◽  
Yanxia Lu ◽  
Crystal Tan ◽  
Xavier F. N. Camous ◽  
Shwe Zin Nyunt ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Community Dwelling ◽  
Antibody Responses

scholarly journals Factors associated with maintenance of antibody responses to influenza vaccine in older, community-dwelling adults

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
H Keipp Talbot ◽  
Laura A Coleman ◽  
Yuwei Zhu ◽  
Sarah Spencer ◽  
Mark Thompson ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Community Dwelling ◽  
Antibody Responses ◽  
Factors Associated

scholarly journals Comparison of the Safety and Immunogenicity of a Novel Matrix-M-adjuvanted Nanoparticle Influenza Vaccine with a Quadrivalent Seasonal Influenza Vaccine in Older Adults: A Randomized Controlled Trial

2020 ◽  
Author(s):  
Vivek Shinde ◽  
Iksung Cho ◽  
Joyce S Plested ◽  
Sapeckshita Agrawal ◽  
Jamie Fiske ◽  
...  
Keyword(s):  
Older Adults ◽  
Influenza Vaccine ◽  
Seasonal Influenza ◽  
Controlled Trial ◽  
Geometric Mean ◽  
Community Dwelling ◽  
Antibody Responses ◽  
Influenza Vaccines ◽  
P Values ◽  
Cytokine Analysis

Background: Improved seasonal influenza vaccines for older adults are urgently needed, which can induce broadly cross-reactive antibodies and enhanced T-cell responses, particularly against A(H3N2) viruses, while avoiding egg-adaptive antigenic changes. Methods: We randomized 2654 clinically-stable, community-dwelling adults ≥65 years of age 1:1 to receive a single intramuscular dose of either Matrix-M-adjuvanted quadrivalent nanoparticle influenza vaccine (qNIV) or a licensed inactivated influenza vaccine (IIV4) in this randomized, observer-blinded, active-comparator controlled trial conducted during the 2019-2020 influenza season. The primary objectives were to demonstrate the non-inferior immunogenicity of qNIV relative to IIV4 against 4 vaccine-homologous strains, based on Day 28 hemagglutination-inhibiting (HAI) antibody responses, described as geometric mean titers and seroconversion rate difference between treatment groups, and to describe the safety of qNIV. Cell-mediated immune (CMI) responses were measured by intracellular cytokine analysis. Findings: qNIV demonstrated immunologic non-inferiority to IIV4 against 4 vaccine-homologous strains as assessed by egg-based HAI antibody responses. Corresponding wild-type HAI antibody responses by qNIV were significantly higher than IIV4 against all 4 vaccine-homologous strains (22-66% increased) and against 6 heterologous A(H3N2) strains (34-46% increased), representing multiple genetically and/or antigenically distinct clades/subclades (all p-values <0.001). qNIV induced 3·1- to 3·9- and 4·0- to 4·9-fold increases in various polyfunctional phenotypes of antigen-specific effector CD4+ T-cells against A(H3N2) and B/Victoria strains at Day 7 post-vaccination, respectively, while corresponding fold-rises induced by IIV4 at Day 7 were 1·3-1·4 and 1·7-2·0 representing a 126-189% improvement in CMI responses for qNIV (all p-values <0·001). Local reactogenicity, primarily mild to moderate and transient pain, was higher in the qNIV group. Interpretation: qNIV was well tolerated and produced a qualitatively and quantitatively enhanced humoral and cellular immune response in older adults. These enhancements may be critical to improving the effectiveness of currently licensed influenza vaccines.

scholarly journals High-Affinity H7 Head and Stalk Domain–Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine

2015 ◽  
Vol 212 (8) ◽  
pp. 1270-1278 ◽  
Author(s):  
Jessica L. Halliley ◽  
Surender Khurana ◽  
Florian Krammer ◽  
Theresa Fitzgerald ◽  
Elizabeth M. Coyle ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Specific Antibody ◽  
Antibody Responses ◽  
Domain Specific ◽  
High Affinity ◽  
Live Attenuated Influenza Vaccine ◽  
Stalk Domain

scholarly journals After adjusting for bias in meta-analysis seasonal influenza vaccine remains effective in community-dwelling elderly

2014 ◽  
Vol 67 (7) ◽  
pp. 734-744 ◽  
Author(s):  
Maryam Darvishian ◽  
Giedre Gefenaite ◽  
Rebecca M. Turner ◽  
Petros Pechlivanoglou ◽  
Wim Van der Hoek ◽  
...  
Keyword(s):  
Influenza Vaccine ◽  
Seasonal Influenza ◽  
Meta Analysis ◽  
Community Dwelling ◽  
Seasonal Influenza Vaccine

scholarly journals Serum Antibody Responses after Intradermal Injection of Influenza Vaccine

2005 ◽  
Vol 2 (1) ◽  
pp. 35-38
Author(s):  
Maliheh Metanat ◽  
Masoud Salehi . ◽  
Batool Sharifi-Mood . ◽  
Mohammad-Reza Safai .
Keyword(s):  
Influenza Vaccine ◽  
Serum Antibody ◽  
Intradermal Injection ◽  
Antibody Responses

scholarly journals Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccine

2020 ◽  
Author(s):  
Sigrid Gouma ◽  
Madison Weirick ◽  
Scott E. Hensley
Keyword(s):  
Influenza Vaccine ◽  
Northern Hemisphere ◽  
Vaccine Strain ◽  
Antibody Responses ◽  
Wild Type ◽  
H3n2 Vaccine

AbstractThe 2019-2020 Northern Hemisphere influenza vaccine includes antigens from 3c3.A H3N2 viruses; however, over half of circulating H3N2 viruses belong to subclade 3c2.A1b. Here, we analyzed antibody responses elicited by the egg-adapted 3c3.A H3N2 vaccine strain in ferrets and humans. We found that this vaccine strain elicits antibodies that have reduced reactivity to a wild-type 3c3.A strain and very limited reactivity to 3c2.A strains, including the currently circulating 3c2.A1b strain.

The Effect of Influenza Vaccination History on Changes in Hemagglutination Inhibition Titers After Receipt of the 2015–2016 Influenza Vaccine in Older Adults in Hong Kong

2019 ◽  
Vol 221 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Tiffany W Y Ng ◽  
Ranawaka A P M Perera ◽  
Vicky J Fang ◽  
Emily M Yau ◽  
J S Malik Peiris ◽  
...  
Keyword(s):  
Older Adults ◽  
Hong Kong ◽  
Influenza Vaccine ◽  
Influenza Vaccination ◽  
Hemagglutination Inhibition ◽  
Age Groups ◽  
Antibody Responses ◽  
Serum Samples ◽  
Vaccination History ◽  
Antibody Titers

Abstract Background Immune responses to influenza vaccination can be weaker in older adults than in other age groups. We hypothesized that antibody responses would be particularly weak among repeat vaccinees when the current and prior season vaccine components are the same. Methods An observational study was conducted among 827 older adults (aged ≥75 years) in Hong Kong. Serum samples were collected immediately before and 1 month after receipt of the 2015–2016 quadrivalent inactivated influenza vaccine. We measured antibody titers with the hemagglutination inhibition assay and compared the mean fold rise from prevaccination to postvaccination titers and the proportions with postvaccination titers ≥40 or ≥160. Results Participants who reported receipt of vaccination during either of the previous 2 years had a lower mean fold rise against all strains than with those who did not. Mean fold rises for A(H3N2) and B/Yamagata were particularly weak after repeated vaccination with the same vaccine strain, but we did not generally find significant differences in the proportions of participants with postvaccination titers ≥40 and ≥160. Conclusions Overall, we found that reduced antibody responses in repeat vaccinees were particularly reduced among older adults who had received vaccination against the same strains in preceding years.

scholarly journals Adjuvanted Influenza Vaccines Elicits Higher Antibody Responses against the A(H3N2) Subtype than Non-Adjuvanted Vaccines

Vaccines ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 704
Author(s):  
Laura Sánchez de Prada ◽  
Iván Sanz Muñoz ◽  
Javier Castrodeza Sanz ◽  
Raúl Ortiz de Lejarazu Leonardo ◽  
José María Eiros Bouza
Keyword(s):  
Influenza Vaccine ◽  
Influenza A ◽  
Seasonal Influenza ◽  
The Elderly ◽  
Antibody Responses ◽  
Serological Response ◽  
Serum Samples ◽  
H3n2 Subtype ◽  
Serological Studies ◽  
Vaccination Campaigns

Background: vaccination is the best approach to prevent influenza infections so far. Serological studies on the effect of different vaccine types are important to address vaccination campaigns and protect our population. In our study, we compared the serological response against influenza A subtypes using the non-adjuvanted influenza vaccine (NAIV) in adults and the elderly and the adjuvanted influenza vaccine (AIV) in the elderly. Methods: We performed a retrospective analysis by hemagglutination inhibition assay (HI) of serum samples right before and 28 days after seasonal influenza vaccination during the 1996–2017 seasons. Conclusions: The AIV presents better performance against the A(H3N2) subtype in the elderly whereas the NAIV induces a better response against A(H1N1)pdm09 in the same group.

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