scholarly journals Hormonal Regulation of Physiology, Innate Immunity and Antibody Response to H1N1 Influenza Virus Infection During Pregnancy

2018 ◽  
Vol 9 ◽  
Author(s):  
Elizabeth Q. Littauer ◽  
Ioanna Skountzou
Keyword(s):  
Innate Immunity ◽  
Influenza Virus ◽  
Virus Infection ◽  
Antibody Response ◽  
Hormonal Regulation ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus

scholarly journals Humans and Ferrets with Prior H1N1 Influenza Virus Infections Do Not Exhibit Evidence of Original Antigenic Sin after Infection or Vaccination with the 2009 Pandemic H1N1 Influenza Virus

2014 ◽  
Vol 21 (5) ◽  
pp. 737-746 ◽  
Author(s):  
Christopher D. O'Donnell ◽  
Amber Wright ◽  
Leatrice Vogel ◽  
Kobporn Boonnak ◽  
John J. Treanor ◽  
...  
Keyword(s):  
Immune Response ◽  
Influenza Virus ◽  
Virus Infection ◽  
Antibody Response ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
T Cell Response ◽  
Pandemic H1n1 ◽  
H1n1 Influenza Virus ◽  
Original Antigenic Sin

ABSTRACTThe hypothesis of original antigenic sin (OAS) states that the imprint established by an individual's first influenza virus infection governs the antibody response thereafter. Subsequent influenza virus infection results in an antibody response against the original infecting virus and an impaired immune response against the newer influenza virus. The purpose of our study was to seek evidence of OAS after infection or vaccination with the 2009 pandemic H1N1 (2009 pH1N1) virus in ferrets and humans previously infected with H1N1 viruses with various antigenic distances from the 2009 pH1N1 virus, including viruses from 1935 through 1999. In ferrets, seasonal H1N1 priming did not diminish the antibody response to infection or vaccination with the 2009 pH1N1 virus, nor did it diminish the T-cell response, indicating the absence of OAS in seasonal H1N1 virus-primed ferrets. Analysis of paired samples of human serum taken before and after vaccination with a monovalent inactivated 2009 pH1N1 vaccine showed a significantly greater-fold rise in the titer of antibody against the 2009 pH1N1 virus than against H1N1 viruses that circulated during the childhood of each subject. Thus, prior experience with H1N1 viruses did not result in an impairment of the antibody response against the 2009 pH1N1 vaccine. Our data from ferrets and humans suggest that prior exposure to H1N1 viruses did not impair the immune response against the 2009 pH1N1 virus.

scholarly journals H1N1 influenza virus infection results in adverse pregnancy outcomes by disrupting tissue-specific hormonal regulation

2017 ◽  
Vol 13 (11) ◽  
pp. e1006757 ◽  
Author(s):  
Elizabeth Q. Littauer ◽  
E. Stein Esser ◽  
Olivia Q. Antao ◽  
Elena V. Vassilieva ◽  
Richard W. Compans ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Pregnancy Outcomes ◽  
Hormonal Regulation ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
Adverse Pregnancy Outcomes ◽  
H1n1 Influenza Virus ◽  
Tissue Specific ◽  
Adverse Pregnancy

scholarly journals Inhibition of H1N1 influenza virus by selenium nanoparticles loaded with zanamivir through p38 and JNK signaling pathways

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35290-35296 ◽  
Author(s):  
Zhengfang Lin ◽  
Yinghua Li ◽  
Min Guo ◽  
Misi Xiao ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Signaling Pathways ◽  
Clinical Application ◽  
Influenza Virus Infection ◽  
Aqueous Solubility ◽  
H1n1 Influenza ◽  
Solubility Limit ◽  
H1n1 Influenza Virus ◽  
Jnk Signaling

Zanamivir is an effective drug for influenza virus infection, but strong molecular polarity and aqueous solubility limit its clinical application.

Electrocardiographic Abnormalities in Patients With Novel H1N1 Influenza Virus Infection

2010 ◽  
Vol 106 (10) ◽  
pp. 1517-1519 ◽  
Author(s):  
Nikolaos Akritidis ◽  
Maria Mastora ◽  
Gerasimos Baxevanos ◽  
Georgios Dimos ◽  
Georgios Pappas
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Novel H1n1 Influenza ◽  
Electrocardiographic Abnormalities

scholarly journals 920 Hospitalized Patients with H1N1 Influenza Virus Infection During Pregnancy in Two Public Hospital in Porto Alegre, Brazil

2010 ◽  
Vol 68 ◽  
pp. 460-460
Author(s):  
Foresti M Jiménez ◽  
P El Beitune ◽  
Pontremoli M Salcedo ◽  
Veleda A Von Ameln ◽  
Pinto F Mastalir ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Public Hospital ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
Hospitalized Patients ◽  
H1n1 Influenza Virus ◽  
Porto Alegre

High expression of recombinant human catalase and its immunomodulatory effects on H1N1 influenza virus infection

2013 ◽  
Vol 48 (4) ◽  
pp. 588-592 ◽  
Author(s):  
Xun-Long Shi ◽  
Zhi-Hui Shi ◽  
Mei-Qing Feng ◽  
Li Ye ◽  
Hai-Yan Zhu ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Virus Infection ◽  
Influenza Virus Infection ◽  
H1n1 Influenza ◽  
High Expression ◽  
H1n1 Influenza Virus ◽  
Immunomodulatory Effects
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