scholarly journals Transcription factors involved in the regulation of natural killer cell development and function: an update

2012 ◽  
Vol 3 ◽  
Author(s):  
Martha Luevano ◽  
Alejandro Madrigal ◽  
Aurore Saudemont
Keyword(s):  
Transcription Factors ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Development ◽  
And Function

scholarly journals mTORC1 and mTORC2 differentially promote natural killer cell development

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Chao Yang ◽  
Shirng-Wern Tsaih ◽  
Angela Lemke ◽  
Michael J Flister ◽  
Monica S Thakar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transcription Factors ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cell ◽  
Cell Development ◽  
Lymphoid Cells ◽  
Innate And Adaptive Immunity ◽  
Mechanistic Target Of Rapamycin

Natural killer (NK) cells are innate lymphoid cells that are essential for innate and adaptive immunity. Mechanistic target of rapamycin (mTOR) is critical for NK cell development; however, the independent roles of mTORC1 or mTORC2 in regulating this process remain unknown. Ncr1iCre-mediated deletion of Rptor or Rictor in mice results in altered homeostatic NK cellularity and impaired development at distinct stages. The transition from the CD27+CD11b− to the CD27+CD11b+ stage is impaired in Rptor cKO mice, while, the terminal maturation from the CD27+CD11b+ to the CD27−CD11b+ stage is compromised in Rictor cKO mice. Mechanistically, Raptor-deficiency renders substantial alteration of the gene expression profile including transcription factors governing early NK cell development. Comparatively, loss of Rictor causes more restricted transcriptome changes. The reduced expression of T-bet correlates with the terminal maturation defects and results from impaired mTORC2-AktS473-FoxO1 signaling. Collectively, our results reveal the divergent roles of mTORC1 and mTORC2 in NK cell development.

scholarly journals Dok1 and Dok2 proteins regulate natural killer cell development and function

2014 ◽  
Vol 33 (17) ◽  
pp. 1928-1940 ◽  
Author(s):  
Javier Celis‐Gutierrez ◽  
Marilyn Boyron ◽  
Thierry Walzer ◽  
Pier Paolo Pandolfi ◽  
Stipan Jonjić ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Development ◽  
And Function

MicroRNA regulation of natural killer cell development and function in leukemia

2019 ◽  
Vol 115 ◽  
pp. 12-20 ◽  
Author(s):  
Jennifer N. Saultz ◽  
Aharon G. Freud ◽  
Bethany L. Mundy-Bosse
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Development ◽  
Microrna Regulation ◽  
And Function

scholarly journals Declined miR‐181a‐5p expression is associated with impaired natural killer cell development and function with aging

Aging Cell ◽  
2021 ◽  
Author(s):  
Jiao Lu ◽  
Shan Li ◽  
Xiaopeng Li ◽  
Wenming Zhao ◽  
Xuefeng Duan ◽  
...  
Keyword(s):  
Natural Killer Cell ◽  
Natural Killer ◽  
Killer Cell ◽  
Cell Development ◽  
And Function
Sign in / Sign up

Export Citation Format

Share Document