scholarly journals Mast Cell Adenosine Receptors Function: A Focus on the A3 Adenosine Receptor and Inflammation

2012 ◽  
Vol 3 ◽  
Author(s):  
Noam Rudich ◽  
Katya Ravid ◽  
Ronit Sagi-Eisenberg
Keyword(s):  
Mast Cell ◽  
Adenosine Receptor ◽  
Adenosine Receptors ◽  
A3 Adenosine Receptor

scholarly journals Role of Mast Cell-Derived Adenosine in Cancer

2019 ◽  
Vol 20 (10) ◽  
pp. 2603 ◽  
Author(s):  
Yaara Gorzalczany ◽  
Ronit Sagi-Eisenberg
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Cancer Cells ◽  
Inflammatory Mediators ◽  
Adenosine Receptor ◽  
Tumor Development ◽  
A3 Adenosine Receptor

Accumulating evidence has highlighted the accumulation of mast cells (MCs) in tumors. However, their impact on tumor development remained controversial. Indeed, cumulative data indicate an enigmatic role for MCs in cancer, whereby depending on the circumstances, which still need to be resolved, MCs function to promote or restrict tumor growth. By responding to multiple stimuli MCs release multiple inflammatory mediators, that contribute to the resolution of infection and resistance to envenomation, but also have the potency to promote or inhibit malignancy. Thus, MCs seem to possess the power to define tumor projections. Given this remarkable plasticity of MC responsiveness, there is an urgent need of understanding how MCs are activated in the tumor microenvironment (TME). We have recently reported on the direct activation of MCs upon contact with cancer cells by a mechanism involving an autocrine formation of adenosine and signaling by the A3 adenosine receptor. Here we summarized the evidence on the role of adenosine signaling in cancer, in MC mediated inflammation and in the MC-cancer crosstalk.

Recent Advances on QSAR-Based Profiling of Agonist and Antagonist A3 Adenosine Receptor Ligands

2013 ◽  
Vol 13 (9) ◽  
pp. 1048-1068 ◽  
Author(s):  
Changliang Deng ◽  
Feng Luan ◽  
Maykel Cruz- Monteagudo ◽  
Fernanda Borges ◽  
M. Natalia D. S. Cordeiro
Keyword(s):  
Adenosine Receptor ◽  
Receptor Ligands ◽  
Recent Advances ◽  
A3 Adenosine Receptor ◽  
Agonist And Antagonist ◽  
Adenosine Receptor Ligands

Canine Mast Cell Adenosine Receptors: Cloning and Expression of the A3 Receptor and Evidence that Degranulation Is Mediated by the A2B Receptor

1997 ◽  
Vol 52 (5) ◽  
pp. 846-860 ◽  
Author(s):  
John A. Auchampach ◽  
Xiaowei Jin ◽  
Tina C. Wan ◽  
George H. Caughey ◽  
Joel Linden
Keyword(s):  
Mast Cell ◽  
Adenosine Receptors ◽  
Cloning And Expression ◽  
A2b Receptor

scholarly journals CF102 an A3 adenosine receptor agonist mediates anti-tumor and anti-inflammatory effects in the liver

2011 ◽  
Vol 226 (9) ◽  
pp. 2438-2447 ◽  
Author(s):  
S. Cohen ◽  
S.M. Stemmer ◽  
G. Zozulya ◽  
A. Ochaion ◽  
R. Patoka ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Adenosine Receptor Agonist ◽  
A3 Adenosine Receptor ◽  
Anti Inflammatory

scholarly journals Activity of LUF6000 and LUF6096 as positive allosteric modulators (PAMs) for the A3 adenosine receptor (AR) is species‐dependent

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Lili Du ◽  
Zhan-Guo Gao ◽  
Jacobus P. D. Veldhoven ◽  
Adriaan P. IJzerman ◽  
Kenneth A. Jacobson ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Allosteric Modulators ◽  
A3 Adenosine Receptor ◽  
Positive Allosteric Modulators

A3 Adenosine Receptor Agonist Inhibited Survival of Breast Cancer Stem Cells via GLI-1 and ERK1/2 Pathway

2017 ◽  
Vol 118 (9) ◽  
pp. 2909-2920 ◽  
Author(s):  
Seyyed Mehdi Jafari ◽  
Mojtaba Panjehpour ◽  
Mahmoud Aghaei ◽  
Hamid Reza Joshaghani ◽  
Seyed Ehsan Enderami
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Adenosine Receptor ◽  
Receptor Agonist ◽  
Breast Cancer Stem Cells ◽  
Adenosine Receptor Agonist ◽  
A3 Adenosine Receptor ◽  
Gli 1
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